Treating Colorectal & Rectal Cancer: Surgery, Radiation Therapy & Systemic Therapy

NYU Langone Health
NYU Langone HealthApr 16, 2026

Why It Matters

Advanced, minimally invasive colorectal surgery shortens recovery and preserves function, driving better patient outcomes and strengthening NYU's competitive edge in specialty oncology care.

Key Takeaways

  • Minimally invasive surgery cuts recovery time to 3‑4 weeks.
  • Robotic and laparoscopic approaches match open surgery outcomes.
  • Sphincter preservation is prioritized, making permanent ostomy rarely necessary.
  • Multidisciplinary team integrates surgery, radiation, and systemic therapies.
  • NYU provides dedicated ostomy, fertility, and survivorship support services.

Summary

The session, held on the final day of National Colorectal Cancer Awareness Month, introduced the latest surgical advances for colon, rectal and anal cancers. Dr. Isabelle Lilionic, an NYU colorectal surgeon, outlined anatomy, treatment goals and the shift from traditional open procedures to minimally invasive laparoscopic and robotic techniques. Key insights included the emphasis on oncologic clearance with healthy margins while preserving organ function. Robotic surgery enables precise work in the narrow pelvis, reducing hospital stays to two‑four days and recovery to three‑four weeks. Approximately 90% of colon‑cancer patients avoid a permanent ostomy, and sphincter‑preserving low anterior resections are standard for rectal disease. Dr. Lilionic highlighted real‑world examples: an early‑stage rectal tumor removed entirely via colonoscope, and NYU’s dedicated ostomy clinic supporting patients with discreet pouching systems. She also noted that permanent ostomies are reserved for cases where sphincter integrity is compromised, and that multidisciplinary coordination with medical oncology, radiation oncology and interventional radiology expands curative options for metastatic disease. The implications are clear: faster recoveries, maintained quality of life and a comprehensive support network position NYU as a leader in colorectal care, attracting referrals and reinforcing its reputation for cutting‑edge, patient‑centered treatment.

Original Description

Treatment for colorectal and rectal cancer has advanced significantly in recent years. Many patients have more options — and better outcomes — than ever before. Hear Perlmutter Cancer Center experts share the latest advances in colorectal and rectal cancer treatment options, including how surgery is used to remove tumors, when radiation therapy may be recommended, and how systemic treatments (chemotherapy, targeted therapy, and immunotherapy) work.
00:00 Opening Remarks
01:48 Surgical Treatment Options for Colorectal and Anal Cancer
16:20 Rectal Cancer – A Radiation Oncologist’s Perspective
33:23 Treating Colorectal Cancer: Systemic Therapy
49:03 Audience Questions & Answers
View slides
Watch Understanding Colorectal Cancer: Prevention, Risk assessment & Screening: https://www.youtube.com/watch?v=TCn5hs32q0o
Learn about the prevention, diagnosis and treatment of colorectal cancer: https://nyulangone.org/conditions/colorectal-cancer
Learn more about the Early Onset Colon and Rectal Cancer Program at Perlmutter Cancer Center: https://nyulangone.org/locations/nyu-langone-colon-rectal-surgery/doctors?sort=availability&page=1&treats=adults
Schedule an Appointment with Doctors who Treatment Colorectal & Rectal Cancer at Perlmutter Cancer Center: https://nyulangone.org/locations/nyu-langone-colon-rectal-surgery/doctors?sort=availability&page=1&treats=adults
Learn more about Clinical Trials & Research at Perlmutter Cancer Center: https://clinicaltrials.med.nyu.edu/cancer/
Learn more about Dr. Toyooki Sonoda: https://nyulangone.org/doctors/1124033576/toyooki-sonoda
Learn more about Dr. Isabelle Le Leannec: https://nyulangone.org/doctors/1124318522/isabelle-c-le-leannec
Learn more about Dr. Ananda Mahadevan: https://nyulangone.org/doctors/1891777389/anand-mahadevan
Learn more about Dr. Rafael Winograd: https://nyulangone.org/doctors/1205282886/rafael-winograd
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To register for free upcoming events from NYU Langone’s Perlmutter Cancer Center, subscribe to our monthly community email newsletter: https://connect.nyulangone.org/email-preferences/sign-up?campaign=pcc_campaign

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