
It delivers strong patient‑data confidentiality for AI‑driven healthcare tools, meeting regulatory demands while keeping models clinically useful.
The rapid adoption of machine‑learning in diagnostics and treatment recommendation has sparked intense scrutiny over patient privacy. Traditional models such as logistic regression provide clear coefficient insights but expose training data when adversaries gain model access, while deeper neural networks hide both data and reasoning. Regulators and health providers therefore face a dilemma: leverage AI’s predictive power without compromising confidential health records. This tension has accelerated research into privacy‑preserving techniques that do not force a trade‑off with model utility.
The proposed quantum‑inspired defence transforms discretised models into tensor‑train (TT) representations, a form of tensor network that compresses and scrambles parameters. By embedding model weights within a low‑rank TT structure, the method renders white‑box attacks ineffective—attackers can no longer infer individual training instances, reducing success rates to random guessing. Simultaneously, the TT format supports efficient computation of marginal and conditional distributions, preserving the interpretability prized in clinical settings. Empirical tests on the LORIS immunotherapy response predictor and comparable shallow neural networks demonstrated black‑box resilience on par with differential privacy, yet without the typical accuracy loss associated with noise injection.
For the healthcare industry, this advancement offers a pragmatic path to embed robust privacy safeguards directly into existing models. Providers can deploy AI tools that meet HIPAA‑style standards while maintaining diagnostic fidelity, fostering greater clinician trust and patient acceptance. Moreover, the post‑training nature of tensorisation means legacy models can be retrofitted without costly retraining. Future work will explore scaling the technique to larger deep‑learning architectures and quantifying its impact on fairness across demographic groups, positioning tensor‑train defence as a cornerstone of responsible AI in medicine.
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