Bold, Humble Innovation Tackles Humanity’s Toughest Challenges
I am deeply honored to be included in the inaugural Forbes 250: America’s Greatest Innovators list. Innovation is rarely a straight line, nor an easy journey. Whether it was democratizing education at Coursera or now redefining drug discovery at insitro , the goal has always been the same: to tackle the hardest problems because those are the ones most worth solving. At insitro, we live by the value to "Be bold," but it also takes a certain amount of humility to walk toward a problem where failure is a very real possibility, but the risk of failing is far outweighed by the cost of not trying at all. Solving these "impossible" challenges also requires us to "Engage with respect" — respect for the complexity of biology, for the power of AI, and most importantly, for the diverse expertise of our teammates. When we bring that humility and rigor together, we don’t just find better solutions; we find better problems. I’m incredibly grateful to to Forbes for this recognition and to the entire team at insitro for their courage in building towards a better future.
AI Predicts Human Trial Outcomes, Boosting Drug Discovery Success
Much of the work on AI in biology aims to replace lengthy, expensive lab experiments with in silico predictions. AlphaFold provided a computational alternative to protein structure determination, and virtual cells aim to predict cellular responses to perturbations. By predicting...
AI Platform Maps Gene Function at Scale, Redefining Drug Discovery
When I launched insitro , the goal was never to make one drug. If that had been the case, we could have used existing tools. Our goal was to change how drugs are made – and to do that, we...
AI‑Driven siRNA CTRO‑1013 Advances to IND for MASLD
I'm thrilled to celebrate a major milestone for insitro: advancing CTRO-1013, our therapeutic siRNA targeting IRS1, into IND-enabling studies for MASLD. What makes this moment so meaningful is not just the progress toward the clinic, but how we got here....
