Dave Asprey (Bulletproof Radio)

What Amount of Collagen Should You Consume?

Collagen supplementation has become popular, but dosage matters. The video advises limiting intake to roughly 20 grams per day, citing research that higher amounts convert hydroxyproline into oxalate, a compound the body struggles to eliminate. The body can excrete about 200 mg of oxalate daily, yet common foods—almonds, raspberries, kale, spinach—already contribute up to a gram. Adding large collagen doses pushes total oxalate beyond safe thresholds, especially for individuals exposed to toxic mold or already high‑oxalate diets. The presenter criticizes biohackers who “slam 100 grams” of collagen, noting that calcium oxalate crystals can slice mitochondrial membranes, reducing cellular energy and prompting systemic calcification and inflammation. He links oxalate accumulation to cellular stiffening, a recognized hallmark of aging. For consumers and health professionals, the takeaway is clear: moderate collagen consumption and monitor overall oxalate intake to protect mitochondrial function and mitigate age‑related tissue rigidity.