Do Longevity Supplements Really Work?
In this episode of Longevity by Design, Dr. Andrea Mayer discusses the scientific evidence behind multivitamin and mineral supplements, highlighting that they may modestly improve cognition, mood, and blood pressure in at-risk or nutritionally deficient individuals, but show little benefit for healthy people or survival outcomes. She emphasizes a personalized approach—testing nutrient levels and dietary habits before supplementing—and warns of quality issues, noting that roughly one‑third of commercial products contain inaccurate dosages or missing ingredients. The conversation also covers emerging geroprotective compounds like alpha‑ketoglutarate and spermidine, which show modest biological age and inflammation benefits in specific, already healthy middle‑aged groups. Overall, Mayer advocates for targeted, evidence‑based supplementation and stronger regulatory oversight of supplement quality.
What Houses, Garbage, and Trucks Teach Us About Aging with Dr. Uri Alon
In this episode, Dr. Uri Alon explains his systems‑biology view of aging using a vivid village metaphor: houses (cells) generate garbage (damage) while a fixed fleet of trucks (the immune system) removes it, leading to overload and a robustness threshold...
Born to Live Longer? Inside the Genetics and Biology of Centenarians
In this episode, Dr. Paola Sebastiani explains how the genetics of extreme longevity are far more complex than a single "longevity gene," highlighting the growing list of genetic variants—such as APOE, chromosome 9 loci, and inflammation‑related regions on chromosome 6—that...
Age Faster or Slower? The Surprising Role of Mental Health and Self-Control
In this episode, Dr. Gil Blander talks with Dr. Terry Moffitt, a leading psychologist behind the 50‑year Dunedin Multidisciplinary Health and Development Study, about how early‑life mental health influences the biological pace of aging. Dr. Moffitt explains the study’s unique...