Macro Notes

Macro Notes

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Exclusive updates on private equity, venture capital, and alternative investments.

The $1 Trillion Cardiovascular Reset
BlogMay 8, 2026

The $1 Trillion Cardiovascular Reset

The blog highlights Eli Lilly's $1.3 billion acquisition of Verve Therapeutics, targeting a one‑shot PCSK9 gene‑editing therapy that could replace daily statins. It underscores the massive adherence problem—up to 75% of statin users stop within two years—and the untapped 1.4 billion‑person market for...

By Macro Notes
The $3 Trillion Quarter
BlogMay 6, 2026

The $3 Trillion Quarter

In early 2026 a consortium of 21 banks is preparing a historic IPO for SpaceX, targeting a $1.75 trillion valuation and a $75 billion raise—2.5 times the size of Saudi Aramco’s record offering. Anthropic and OpenAI are slated to follow, together adding roughly...

By Macro Notes
Macro Notes Predictions — Issue #1 · Q2 2026
BlogMay 4, 2026

Macro Notes Predictions — Issue #1 · Q2 2026

The author launches a quarterly macro outlook that scores each prediction for transparency, beginning with 12 bets ranging from aggressive AI‑hyperscaler corrections to defensive private‑credit risks. Key data points include $715 billion AI hyperscaler capex, uranium spot prices above $100 per...

By Macro Notes
Why Ports Became the Strategic Asset of the Decade
BlogApr 30, 2026

Why Ports Became the Strategic Asset of the Decade

On March 4 2025 CK Hutchison announced the sale of 80% of its global port portfolio to a Western consortium led by BlackRock, MSC and Global Infrastructure Partners for $22.8 billion. The transaction covers 43 ports in 23 countries, including the Panama Canal...

By Macro Notes
The Pharma Sovereignty Playbook: How I’m Playing the $1.5 Trillion Drug Supply Crisis
BlogApr 29, 2026

The Pharma Sovereignty Playbook: How I’m Playing the $1.5 Trillion Drug Supply Crisis

A 2023 FDA inspection of Intas Pharmaceuticals’ plant in India halted half of the U.S. cisplatin supply, triggering nationwide shortages of both cisplatin and its substitute carboplatin. The crisis highlighted that only 24% of active pharmaceutical ingredient (API) manufacturing for...

By Macro Notes
The 17-Year Orderbook Nobody’s Tracking — Inside Shipbuilding’s Quiet Supercycle
BlogApr 22, 2026

The 17-Year Orderbook Nobody’s Tracking — Inside Shipbuilding’s Quiet Supercycle

A veteran LNG shipping CEO warned in December 2025 that the global orderbook of 234 new LNG carriers for 2026‑2030 will fall far short of the 229 million tons of liquefaction capacity slated for completion by 2030, creating a 70 Mt shortfall....

By Macro Notes
The War Premium — Defense, Insurance, and the New Cost of Global Trade
BlogApr 16, 2026

The War Premium — Defense, Insurance, and the New Cost of Global Trade

In February 2026 the U.S. and Israel’s airstrikes on Iran triggered a rapid collapse of traffic through the Strait of Hormuz, not by missiles but by a spike in war‑risk insurance premiums. Premiums surged from under 0.25% to 5% of...

By Macro Notes
The $100 Trillion Energy Crisis Nobody Saw Coming
BlogMar 16, 2026

The $100 Trillion Energy Crisis Nobody Saw Coming

The Strait of Hormuz shut completely after Iran’s retaliation, halting all commercial traffic and stranding nearly a fifth of the global tanker fleet. While crude oil found temporary relief through Saudi and UAE pipelines and strategic reserves, other energy streams—LNG,...

By Macro Notes