#394 ‒ Sleep Pharmacology: The Role of Medications in Healthy Sleep, the Promise of Emerging Therapies, and the Evidence for...
In this episode, host Peter Atiyah breaks down sleep pharmacology, explaining how sleep problems stem from four core mechanisms—sleep pressure, circadian timing, hyperarousal, and sleep architecture—and why matching medication to the specific dysfunction is crucial. He reviews the major classes of prescription sleep aids, their effects on sleep stages, side‑effect profiles, and dependence risks, while emphasizing that behavioral hygiene remains the foundation of healthy sleep. The discussion also highlights emerging dual orexin receptor antagonists (DORAs) and their potential role in preventing Alzheimer’s in high‑risk individuals, and touches on off‑label drugs and supplements. Throughout, Atiyah stresses a clinician‑guided, problem‑specific approach rather than a one‑size‑fits‑all prescription strategy.
#393 ‒ AMA #85: A Guide to Medications and Supplements: Determining What to Take, What to Skip, and How to...
In this 13‑minute AMA preview, Dr. Peter Atiyah explains how to choose medications and supplements by first defining a concrete health problem—specific metric, threshold, and timeline—rather than vague goals like “more energy.” He categorizes interventions into four "jobs"—disease treatment, symptom...
#392 - Genetic Testing: When It's Valuable, How to Choose the Right Test, and What to Do with the Results
In this episode, host Peter Atiyah demystifies genetic testing by outlining when it truly adds value, how to select the appropriate test, and how to act on the results. He explains that most genetic information is probabilistic, highlights the limits...
#390 ‒ AMA #84: Family Health History, Preventing Heart Disease, Metabolic Health, Strength Training Efficiency, Dementia Risk Reduction, NAD Supplements,...
In this brief AMA preview, Dr. Peter Atiyah tackles a wide‑range of practical health questions, from building a useful family health history and its role versus genetic testing, to why heart disease remains under‑prevented despite available tools. He discusses the...
#389 - Thinking Scientifically: Why It's Hard, Why It Matters, and a Practical Toolkit
In this episode, host Peter Atiyah explores what it means to think scientifically, why it’s inherently difficult for humans, and how we can improve this skill. He defines scientific thinking as generating hypotheses, testing them against evidence, updating beliefs, and...
#385 - AMA #82: Applying the Tools of Longevity in the Real World: Disease Prevention, DEXA Scans, Artificial Sweeteners, Injury...
In this AMA sneak‑peek, Dr. Peter Atiyah fielded listener questions on practical longevity strategies, covering how health priorities shift across the 20s, 40s, and 60s+, the hierarchy of chronic disease risk (cardiovascular, cancer, neurodegeneration, metabolic), and the most useful consumer...
#384 - Special Episode — Obicetrapib: The CETP Inhibitor with Cardiovascular Benefits and Potential Alzheimer's Prevention
In this special episode, host Peter Atiyah dives deep into obicetrapib, a CETP inhibitor that lowers LDL‑C and ApoB while raising HDL‑C, and examines its renewed promise in cardiovascular disease and potential Alzheimer’s prevention, especially for APOE‑E4 carriers. He outlines...