Decoding Bio (Substack)

Decoding Bio (Substack)

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Weekly newsletter highlighting breakthrough biotech news and trends – a community of scientists, founders, and experts distilling the latest in biotech.

Scaling Bio 008: Serif Biomedicines' Jake Rubens on Turning Modified DNA Into a New Class of Medicine
Podcast•Apr 21, 2026•0 min

Scaling Bio 008: Serif Biomedicines' Jake Rubens on Turning Modified DNA Into a New Class of Medicine

In this episode, Jake Rubens of Serif Biomedicines explains how the company is turning DNA into a new class of medicines by using chemically modified DNA and a protein co‑factor to overcome DNA’s historic immunogenicity and delivery challenges. He contrasts...

By Decoding Bio (Substack)
Substack Live | Flagship Pioneering Announcement: Building on the Code of Life
News•Apr 20, 2026

Substack Live | Flagship Pioneering Announcement: Building on the Code of Life

Flagship Pioneering is hosting a Substack Live session on April 21 at 12:30 pm ET featuring origination partner Jake Rubens. The event will unveil a new initiative that leverages the "code of life" to advance synthetic‑biology‑based therapeutics. Rubens, an MIT‑trained synthetic biologist...

By Decoding Bio (Substack)
The Bioelectric Tech Stack
News•Feb 5, 2026

The Bioelectric Tech Stack

The episode frames biomanufacturing as a layer of the emerging electric tech stack, arguing that biology will become the chemical manufacturing layer that converts cheap electricity and feedstocks into high‑value molecules. It contrasts China’s systematic investment in the physical infrastructure—feedstock...

By Decoding Bio (Substack)
Decoding Bio (Substack) | Pulse