Innovations in Clinical Neuroscience

Letters to the Editor: Post-SSRI Sexual Dysfunction: Challenges and Treatment Approaches

Selective serotonin reuptake inhibitors revolutionized mood‑disorder treatment but often cause sexual side effects. A subset of patients experiences post‑SSRI sexual dysfunction (PSSD), where libido loss, erectile problems and orgasmic difficulties persist months or years after discontinuation. The underlying neurochemical mechanisms remain speculative, involving long‑term serotonin receptor alterations and dopamine imbalance. No standardized diagnostic criteria or treatment protocol exist, prompting clinicians to rely on medication switches, adjunct therapies, and psychotherapy, while research explores serotonin‑targeted drugs and neuromodulation.