Nature – Health Policy (topic)

Editorial Expression of Concern: The Gene Product Murr1 Restricts HIV-1 Replication in Resting CD4+ Lymphocytes

An expression of concern has been issued for a 2003 Nature paper that reported the gene product Murr1 restricts HIV‑1 replication in resting CD4⁺ lymphocytes. The editors identified duplicated control panels in Figure 3b, which were meant to demonstrate siRNA activity, and noted that the raw data supporting these figures are no longer available. The duplication also raises questions about the specificity controls shown in Figures 3c and 3d. As a result, the validity of the original claim about Murr1’s antiviral role is now uncertain.