No Priors
A venture-focused AI podcast at the intersection of technology, startups, and innovation. Investor co-hosts Sarah Guo and Elad Gil engage in timely conversations with world-leading AI engineers, researchers, and founders about the big questions in AI today. They discuss how close we are to AGI, which markets are primed for AI disruption, cultural and societal shifts from AI, and the state-of-the-art in research – serving as your guide to the AI revolution.
Biohub: The Future of Biology Is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
In this episode, Mark Zuckerberg, Priscilla Chan, and Alex Rives discuss the mission of Biohub and its $500 million Virtual Biology Initiative, which aims to accelerate scientific discovery by creating open‑source tools and massive biological datasets. They explain how Biohub combines frontier AI with cutting‑edge wet‑lab work to model biology hierarchically—from protein structures to whole cells—enabling researchers worldwide to access and build on shared resources. Rives highlights the transition from early projects like single‑cell sequencing and the Human Cell Atlas to advanced AI models that can predict protein folding, cellular behavior, and eventually whole‑organism systems. The guests stress that Biohub’s goal isn’t to cure diseases directly, but to democratize tools that let the entire scientific community move faster toward that ultimate aim.
Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
In this episode, Maxim Bar Kogan, CEO of Onyx Security, explains how his company is building AI‑guardian agents that monitor and control other autonomous AI agents used by enterprises. He traces the rise of autonomous agents from early experiments like...
Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg
In this episode, Under Secretary of State for Economic Affairs Jacob Helberg outlines the Pax Silica initiative, a 14‑nation coalition aimed at securing the AI supply chain through forward‑deployed industrial zones, starting with a 4,000‑acre economic security zone in the...
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
Long Lake CEO Alexander Taubman discusses the company’s groundbreaking AI‑driven take‑private of Amex Global Business Travel for $6.3 billion, positioning it as possibly the world’s first AI‑powered roll‑up. He explains how Long Lake’s Nexus platform, a shared AI infrastructure, automates workflows,...
Scaling Global Organizations in the Age of AI with ServiceNow CEO Bill McDermott
In this episode, ServiceNow CEO Bill McDermott discusses how AI and SaaS are reshaping enterprise platforms, emphasizing the massive hidden costs of replacing legacy systems with AI models. He shares personal leadership lessons—from buying a deli as a teen to...
From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
In this episode, Sarah Guo talks with Notion co‑founder Simon Last about the company’s evolution from a writing assistant to a platform that lets users create autonomous AI agents capable of building integrations and writing code. Simon explains the technical...
How Capital Is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil Tiwari
In this episode, Magnetar Capital Managing Director Neil Tiwari explains how his firm finances the massive AI compute infrastructure boom, leveraging its expertise in private credit, real‑estate, and energy assets. He details innovative financing structures—such as SPV debt backed by...
AI and the Future of Warfare with US Under Secretary of War Emil Michael
In this episode, Under Secretary of War Emil Michael explains how the Department of War is deploying a generative AI platform, GenAI.mil, to over a million users within its first month, leveraging models like Gemini and Grok to boost decision‑making...
Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe Pereyra
In this episode, Harvey co‑founder and president Gabe Pereyra explains how the company has scaled to nearly 1,000 enterprise clients by using agentic AI to automate complex legal workflows such as fund formation and M&A, rather than merely boosting individual...
Sunday Robotics: Scaling the Home Robot Revolution with Co-Founders Tony Zhao and Cheng Chi
In this episode, Sarah Guo talks with Sunday Robotics co‑founders Tony Zhao and Cheng Chi about the emerging "GPT moment" in AI robotics and their flagship product, Memo, a general‑intelligence home robot. They explain how diffusion policy, ACT/ALOHA frameworks, and...
How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara
In this episode, Sarah Guo talks with Benchling co‑founder and CEO Sajith Wickramasekara about the systemic bottlenecks in drug development and how Benchling’s AI‑driven platform is reshaping biotech R&D. Wickramasekara explains how AI agents and simulation can speed up experiments,...
Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar Ramaswamy
Snowflake is shifting from a pure data‑warehouse model to an AI‑first strategy with Snowflake Intelligence, an enterprise‑wide agent platform that puts AI assistants in the hands of every employee, not just data teams. In a podcast with CEO Sridhar Ramaswamy,...