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Omics! Omics!

Omics! Omics!

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Personal blog of a computational biologist covering genomics, DNA sequencing technology, and drug R&D with technical depth and humor

Recent Posts

Illumina Constellation Becomes TruePath Genome
News•Feb 25, 2026

Illumina Constellation Becomes TruePath Genome

Illumina has rebranded its Constellation mapped‑read system as TruePath Genome and launched it commercially at $395 per genome. The technology performs on‑flowcell tagmentation of high‑molecular‑weight DNA, using DRAGEN to infer proximity and generate haplotype blocks on NovaSeq X 10B flowcells. TruePath Genome claims faster sample‑to‑insight times—about 32 hours versus 59 hours for PacBio HiFi—while reducing consumables and input DNA requirements. A roadmap includes multiplexing in 2027 and 5‑mC chemistry by 2028, extending the platform to broader applications.

By Omics! Omics!
UltraMarathonRT: When Your Reverse Transcription Must Go Long
News•Dec 16, 2025

UltraMarathonRT: When Your Reverse Transcription Must Go Long

RNAConnect has launched a new kit for Oxford Nanopore direct‑RNA sequencing that uses UltraMarathonRT, a group II intron‑derived reverse transcriptase. Unlike traditional AMV or M‑MLV enzymes, UltraMarathonRT is highly processive, can copy RNA longer than 30 kb, and works at a gentle...

By Omics! Omics!