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Rough Diamonds (Substack)

Rough Diamonds (Substack)

Publication
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Biotech-focused Substack by Sarah Constantin, exploring cutting-edge research and developments in biotechnology with in-depth analysis and commentary.

Recent Posts

Cancer-Selective, Pan-Essential Targets From DepMap
News•Jan 9, 2026

Cancer-Selective, Pan-Essential Targets From DepMap

The episode explores a data-driven search for pan‑essential cancer targets—genes whose knockout kills many cancer cell lines but spares normal cells—using the DepMap dataset and Claude‑generated code. It presents the top‑50 selective genes, highlights several promising candidates such as YRDC, TFRC, PHF5A, ADSL, SEPHS2, and NMT1, and discusses their druggability, existing clinical efforts, and potential as broad‑spectrum therapies. The host reflects on how AI‑assisted coding accelerated the project and underscores the balance between rapid experimentation and the need for rigorous validation.

By Rough Diamonds (Substack)
Measuring Drug Target Success
News•Dec 16, 2025

Measuring Drug Target Success

The episode explores how drug targets are identified and validated, highlighting genetic, animal, and in‑vitro evidence as key sources. It discusses the limited predictive power of pre‑clinical data, noting that genetically validated targets double the odds of clinical success while...

By Rough Diamonds (Substack)