Recent Posts
News•Feb 27, 2026
Cellular Reprogramming: The Expert Roundup
A round‑up of leading experts highlights how cellular reprogramming has moved from a laboratory curiosity to a near‑clinical anti‑aging platform. Researchers describe partial, epigenetic‑focused approaches that can rejuvenate cells without erasing identity, and four biotech firms outline their distinct delivery methods, safety strategies, and early‑phase trial plans. The article notes that clinical trials for eye, blood and brain indications are imminent, while regulatory and biomarker challenges still shape the timeline. Collectively, the experts predict the first approvals will emerge in narrowly defined disease settings within the next few years.
By SENS Research Foundation – The SENSible Blog
News•Feb 25, 2026
Menopausal Hormone Therapy Does Not Increase Mortality
A Danish register study of over 800,000 women examined the long‑term safety of menopausal hormone therapy (MHT). About 12% of participants used MHT for a median of 1.7 years, and the analysis found no association between MHT use and all‑cause...
By SENS Research Foundation – The SENSible Blog
News•Feb 24, 2026
Thermogeneration by White Fat Could Be Used to Treat Obesity
Researchers at Cornell uncovered a previously unknown thermogenic pathway in white adipocytes, where free fatty acids induce proton leakage through the mitochondrial ADP/ATP carrier (AAC). This AAC‑mediated uncoupling mirrors brown‑fat heat production without involving UCP1. In mouse models, enhancing intracellular...
By SENS Research Foundation – The SENSible Blog
News•Feb 23, 2026
How a Sirtuin Protects Against Brain Diseases
Researchers in Aging Cell reveal that the nuclear sirtuin SIRT6 safeguards brain health by preserving nucleolar integrity and curbing excess protein synthesis. Loss of SIRT6 triggers nucleolar enlargement, heightened rRNA production, and uncontrolled protein translation, leading to protein aggregation and...
By SENS Research Foundation – The SENSible Blog
News•Feb 20, 2026
AI Tool Sets New Standard in Diagnosing Rare Diseases
A new multi‑agent system called DeepRare, built on the DeepSeek‑V3 large language model and over 40 specialized tools, outperformed 15 competing AI models and human physicians in diagnosing rare diseases. Across 6,401 cases covering 2,919 rare conditions, it achieved a...
By SENS Research Foundation – The SENSible Blog
News•Feb 19, 2026
A Circulating Inflammation Suppressor Decreases Mortality
Researchers used Mendelian randomization to demonstrate that the inflammatory cytokine IL6 directly increases all‑cause mortality, while its soluble receptor IL6R has the opposite effect. Elevated circulating IL6R was linked to lower risk of lung cancer, diabetes, stroke and coronary artery...
By SENS Research Foundation – The SENSible Blog
News•Feb 18, 2026
Global Conference to Tackle Longevity Clinical Translation
The National University of Singapore Academy for Healthy Longevity is hosting the Geromedicine Conference on February 26-27, 2026, bringing together geroscience researchers, clinicians, and industry leaders. The event emphasizes clinical translation of molecules such as NAD+ precursors, urolithin A, and ergothioneine,...
By SENS Research Foundation – The SENSible Blog
News•Feb 16, 2026
Silencing Growth Hormone Has Strong Effects in Mouse Brains
Researchers engineered mice lacking growth hormone receptors specifically in adipose tissue (Ad‑GHRKO) and observed striking brain benefits in aged males. Compared with control mice, the Ad‑GHRKO group showed increased neuronal activity, reduced neuroinflammation, lower tau phosphorylation, and fewer senescence markers....
By SENS Research Foundation – The SENSible Blog
News•Feb 13, 2026
Longevity Innovation Forum in San Diego
Longevity Global is launching the inaugural Longevity Innovation Forum in San Diego on March 11‑12, 2026, gathering leading scientists, clinicians, biotech founders and investors to accelerate healthy‑aging research. The two‑day summit features high‑profile speakers such as Mike Snyder, Eric Verdin,...
By SENS Research Foundation – The SENSible Blog
News•Feb 13, 2026
Cellular Reprogramming Rescues Memory-Encoding Neurons
Scientists at EPFL applied a three‑factor (OSK) partial reprogramming cocktail to memory‑encoding engram neurons in 9‑10‑month‑old mice and Alzheimer’s‑model strains. Using a dual‑AAV system gated by doxycycline, OSK expression was limited to neurons active during a learning event, preserving cell...
By SENS Research Foundation – The SENSible Blog
News•Feb 12, 2026
Creating CAR-T Cells Using Current Alzheimer’s Antibodies
Researchers engineered CD4+ T cells with chimeric antigen receptors (CARs) derived from FDA‑approved Alzheimer’s antibodies aducanumab and lecanemab. The lecanemab‑based CAR (Lec28z) selectively bound fibrillar amyloid‑beta and reduced plaque burden in mouse brains, especially when delivered via transient mRNA transfection....
By SENS Research Foundation – The SENSible Blog
News•Feb 11, 2026
Young Microbes Rejuvenate Intestinal Function in Mice
Researchers performed heterochronic fecal microbiota transplants, moving gut microbes from young to aged mice, which reactivated canonical Wnt signaling and enhanced intestinal stem cell regeneration. Aged mice receiving young microbiota showed increased expression of Wnt3, Ascl2, Lgr5 and improved epithelial...
By SENS Research Foundation – The SENSible Blog