
Running Through Walls
The 2026 healthcare outlook highlights relentless growth in pharmacy expenditures, with analysts projecting double‑digit increases despite ongoing drug‑pricing negotiations. Commercial insurers remain the dominant payer, and attempts to lower U.S. prices are offset by higher international pricing strategies. A parallel development is the anticipated launch of TrumpRx, a government‑backed price‑comparison portal expected in early 2025. While the site will provide transparent pricing data, its e‑commerce capabilities will remain limited, forcing consumers to complete purchases through existing retailers such as Amazon or Mark Cuban’s pharmacy.
Regulatory momentum is also reshaping AI adoption in medicine. A new Medicare billing code specifically for artificial‑intelligence services compels providers to deploy genuine AI solutions rather than superficial human‑in‑the‑loop workarounds. This incentive accelerates AI use in prior‑authorization and revenue‑cycle management, yet it also seeds friction as payer‑side and provider‑side bots compete without a shared framework. The resulting tug‑of‑war may inflate processing times, increase coding disputes, and raise fraud risk, while consumer‑facing AI doctors confront high churn rates that threaten sustainable business models.
Strategic bets are redefining the Medicare Advantage landscape. Humana’s aggressive enrollment drive aims to capture a million new lives, betting on upcoming rate adjustments to offset potential margin erosion. Meanwhile, industry observers speculate that Epic could be acquired by Microsoft, merging electronic‑health‑record expertise with cloud‑AI capabilities. Apple’s long‑promised non‑invasive glucose monitor also remains a wildcard, with its massive distribution network poised to disrupt traditional diagnostics if delivered soon. Together, these moves illustrate how technology, policy, and scale will converge to shape health‑care economics through 2026.
Siobhan Nolan Mangini, Bob Kocher and Bryan Roberts delve deeper into their 2026 predictions for healthcare in this special episode of Running Through Walls. They discuss what they've already gotten right on AI, what they see ahead for inflation and TrumpRx, and more. To read all 10 of their annual predictions, plus 2 bonus predicitons, check out their article in Fortune Magazine.
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