NIH Must Fund Human Trials for Untested Peptide Therapies
Why isn't the NIH funding human trials on the popular peptides lacking replicable or significant clinical data? BPC-157, TB-500, AOD-9604, MOTS-c, Semax, Selank - today just anecdotes, forum postings plus mostly animal studies are the evidence base. No pharma sponsor willing to drop tens of millions to fund these studies, of course. This is exactly what public funding is for and could broaden use if efficacy/safety is shown and FDA acts to move these to compounding ok list. Taxpayers deserve real evidence. Time to close the gap so people arent relying on fruit fly, mouse, or n=12 studies from single sites in eastern europe from 35 years ago.
Current Epitalon Dosing Likely 500‑fold Excessive
Epitalon has become a popular peptide in some circles. Could the current dosing protocols be off by an order of magnitude due to mis-application of original studies? Intriguing paper: "the 5 to 10 mg human dosing paradigm originates from studies conducted...
Lilly Pushes Biologic Classification for Profit, Sidestepping Science
The Lilly reply brief is in for the retatrutide is a biologic federal appeals court case....but far more interesting is the Outsourcing Facilities Association's amicus brief (the 503A lobby).... "Lilly asks this Court to ignore plain text, disregard agency scientific expertise,...
CMS Freezes New Hospice, Home‑health Medicare Enrollments for Six Months
Wow The Centers for Medicare & Medicaid Services is imposing a six-month nationwide moratorium on new Medicare enrollments for hospices and home health agencies as part of a broader effort to combat fraud, waste and abuse in the Medicare program.
Big Pharma Exit Ends Sonoma’s Startup‑to‑Corporate Dream
I spent two years early in my career working with some amazing people at this Medtronic site in Sonoma County. MDT had just bought a coronary stent start-up called AVE (Arterial Vascular Engineering) for $4b when I joined -...
AI Meeting Transcripts Threaten Legal Discovery, Companies Warned
Most companies should be banning AI note takers from video meetings - good luck on your depositions and discovery otherwise. All Those A.I. Note Takers? They’re Making Lawyers Very Nervous. https://t.co/N4ieeW9xtN
Banning SSRIs Is Unreasonable for Mental Health Care
Absolutely batshit. Can we do better on mental health. Of course. Is banning SSRI even remotely a good idea - not unless you are an utter doctrinaire moron.
AI‑enhanced Dog Breath Test Detects Cancers with 90%+ Accuracy
New MCED / cancer screening test: Dogs smell human breathing + Bayesian AI detects multiple cancers with 90.8% sensitivity & 91.3% specificity (AUC 0.962), even in early stages. Phase II India study (1,502 people, 7 cancer types)- strong potential for affordable...
FDA Blocks Proven Therapies, Permits Untested Peptides
So let me get this straight - this FDA 1) won’t approve life saving melanoma and Huntington’s disease drugs based on BS objections related to control groups that would not be ethical 2) blocks large study showing exquisite safety of...
AI Cheapens Scans, Boosts Radiologist Demand and Salaries
The Radiologist Paradox "A decade ago, AI was supposed to replace radiologists. Today, radiologists make more than $500,000 per year, and their employment continues to grow, see chart below. Reading scans is a task, not a job, and when the...
Over Half of Gray Market Peptides Fail Quality Standards
New pre-print on gray market peptides using @finnrick_tests data: 41.6% to 71.1% of gray market peptide samples failed to meet basic quality criteria, and measurable endotoxin contamination was present in 15% of samples. @Krysia830073
TRT Gel/Injection Shows More Adverse Events Than Clomiphene
Interesting retrospective chart-based study in VA population - TRT gel/injection vs. clomiphene for hypogonadism. Matched populations at baseline. Far higher rates of AEs with gel/injection vs. clomiphene. "TRT was associated with an increased incidence of mortality, CVA, CAD, hypertension,...
Former FDA Staffer Cites Political Pressure Blocking Rare‑disease Drug Approval
Former FDA staffer - “I recently left FDA due to the political pressure I was receiving to withhold my recommendation for approval for a drug that was intended for a rare disease. I was part of a review division that...
Officials See Pro‑vaccine Pick as Positive, yet Insufficient
"Two former CDC officials, who spoke to MS NOW on condition of anonymity, said Schwartz’s support of vaccines was a good sign, but they cautioned that touting vaccines is a low bar to clear for a leader of the agency...
10,000 Rare Live Recordings From Nirvana to Phish Released Online
Amazing. From Early Nirvana To Phish, A Chicago Fan's Secret Recordings Of 10,000 Shows Are Now Online https://t.co/0ToFE4VRlI