Aging Is Genome‑Encoded, Systemic, and Modifiable
aging is systems-driven & encoded by the whole genome there are species-specific rates of maturation, preservation & decline that are powerfully modifiable for the worse & subtly modifiable for the better there are also enormous numbers of ppl making claims that are not evidence-based
Chemical Reprogramming Triggers Toxic Lipid Droplets In Vivo
https://t.co/F6dZ4lFcUZ problem is that most groups don't publish negative results here's a recent paper from @gladyshev_lab showing that chemical reprogramming (yes, different thank OSKM) causes lipid droplet formation and significant in vivo toxicity
Vaccines, Not Geroscience, Drove Lifespan Gains; GLP‑1s Now Hype
fun facts: class of medicines that have most greatly extended human lifespan: vaccines class of medicines longevity docs are most excited by now: GLP1s did these come from geroscience? they did not by the way, NR didn't come from geroscience either
Longevity Genes Trade Growth for Extended Lifespan
if there were no aging, you would not have matured as a man in fact, the most powerful monogenic life-extending mutations in mice impair growth and maturation
Curing Disease Doesn't Change Its Classification,
cool. as soon as you show me a worm or mouse you modify so that it doesn’t degrade or end life, i’ll accept your premise your position is it’s a disease if it’s curable now i want to know if you told...
Unretracted Bad Papers Poison LLMs and Waste Resources
one of the problems with journals not retracting papers known to be wrong is that LLMs are mistrained, additional ppl are sent into rabbit holes, and the whole system wastes human & computational resources on 💩 RT w examples of papers...
Exercise and Modest Protein Mimic Rapamycin’s Benefits,
is the point as which Dr Pfleger wants to chime in on the expected longer term outcomes of protein maxing in humans?
Questioning Geroscience: Shingles Vaccine Shows Unexpected Effects
i don’t believe there is an evidence basis for the value proposition of the geroscience hypothesis shingles vaccination was targeted to a specific virus yet this one intervention prevents Alzheimer’s disease and increases all cause mortality is the geroscience hypothesis...
Discrepancy in Mouse Counts Raises Partial Reprogramming Concerns
okay, tell me why you think browder et al had 21 mice in -dox and only 15 mice in the +dox group when they did partial reprogramming? https://t.co/gedJiKSRKo 6 more mice in the dox group got tummy aches and asked out of...
OSK Reprogramming Triggers Tumors, Undermining Mouse Study Confidence
OSK reprogramming also produces tumors see https://t.co/dNhcHVSBf3 cancer is a selective process clones grow out because they have a proliferative advantage or apoptotic disadvantage when mouse papers say no cancer despite the fact that half of lab mice die from cancer, i don't feel...
IPSC Therapies Succeed; In‑vivo Reprogramming Remains Hype
your regular reminder that Yamanaka factor-driven production of iPSCs is already producing real medicine (eg dopaminergic neural progenitor for Parkinson's, cardiomyocyte sheets for heart failure & more) iPSC tech is not done in vivo... ppl isolate the well behaved cells away...
Shingles Vaccine Beats Geroscience in Reducing Dementia
a different take: the shingles vaccine lowers dementia and all cause mortality and it’s targeted to a specific virus, not the process of aging so far the data say the score is shingles vaccine 1, geroscience hypothesis 0 and I could say the...
Targeting “Zombie” Cells Misguided for Healthy Aging
it was always dumb to talk about killing so called zombie cells in the context of healthy aging
Exploring Known and Unknowns in NAD Coenzyme Research
looking forward to concluding next week's NAD for Health conference in Copenhagen with a talk on Known Knowns and Known Unknowns in NAD Coenzyme Research.... see you there https://t.co/hLAnAq7Fay
NR/NMN Lack Human Anti‑Aging Proof, Only PAD Benefits
stated as a critique but what does this mean as no drug has been demonstrated to have anti-aging effects in human clinical trials NR is active versus inflammaging and PAD, which is an age-related conditions affecting 10s of millions of americans you...