Jacob Plieth

Jacob Plieth

Creator
0 followers

Biotech journalist (focus on oncology); provides sharp analysis of cancer drug data and industry developments.

ALLO May
SocialApr 13, 2026

ALLO May

Has $ALLO found a niche for allo Car-T at last? It's early days, so the answer is maybe. Via @APEXONCO -> https://t.co/bO3A1hpAY8

By Jacob Plieth
NVS Sells Darovasertib for $6M in Cash, Stock
SocialApr 13, 2026

NVS Sells Darovasertib for $6M in Cash, Stock

Let's remember again that $NVS dumped off darovasertib for $2.5m in cash + $3.5m in $IDYA series B preferred stock.

By Jacob Plieth
ALLO's Alpha-3 DLBCL Data Set to Spark Pre‑Market Move
SocialApr 13, 2026

ALLO's Alpha-3 DLBCL Data Set to Spark Pre‑Market Move

Key $ALLO catalyst coming pre market today, with first data from cema-cel's Alpha-3 study in DLBCL consolidation. What to look for: https://t.co/a19BVEppqP

By Jacob Plieth
Darovasertib Shows Promise in Optimum-02 Uveal Melanoma Trial
SocialApr 13, 2026

Darovasertib Shows Promise in Optimum-02 Uveal Melanoma Trial

$IDYA darovasertib data from registrational Optimum-02 trial in uveal melanoma are out. What to look for: https://t.co/1LQa0X6xJa

By Jacob Plieth
Investors Demand Immediate Release of Market-Sensitive Data
SocialApr 10, 2026

Investors Demand Immediate Release of Market-Sensitive Data

This is getting quite tiresome: first $ORIC, now $ALLO & $IDYA. Why are you sitting on market-sensitive data rather than releasing it now? https://t.co/N8q95re7ho

By Jacob Plieth
IPHYF Falls Short of Promise, Future Uncertain
SocialMar 26, 2026

IPHYF Falls Short of Promise, Future Uncertain

Of all the IO companies I've met and covered in the past ~15 years I'm struggling to think of one that's been more disappointing vs its initial promise than $IPHYF. Will it even last beyond Q3? Via @ByMadeleineA -> https://t.co/DepdZfDBdY

By Jacob Plieth
Prescribing CORT Lifyorli Differs From Cushing’s Experience
SocialMar 26, 2026

Prescribing CORT Lifyorli Differs From Cushing’s Experience

Here's prescribing info for $CORT Lifyorli -> https://t.co/i46Whl5lX6 Why so different from the experience in Cushing's? https://t.co/EqvbCApqHn

By Jacob Plieth
MRK Likely to Rerun TERN Study for Data
SocialMar 25, 2026

MRK Likely to Rerun TERN Study for Data

Based on previous form $MRK will probably now rerun the $TERN study, just to prove to itself that the data were real.

By Jacob Plieth
TERN's Termination Terms Hint MRK Could Be Outbid
SocialMar 25, 2026

TERN's Termination Terms Hint MRK Could Be Outbid

For those wondering if $MRK might be outbid, here are the deal termination terms from $TERN https://t.co/TbM3rWyEoG

By Jacob Plieth
US Patients Access Zegfrovy via Apex Oncology
SocialMar 23, 2026

US Patients Access Zegfrovy via Apex Oncology

Another win for Dizal, but how do US patients get hold of Zegfrovy? Via @ApexOnco -> https://t.co/4GVjyHS9vz https://t.co/bjjrnZkNL6

By Jacob Plieth
NVS
SocialMar 20, 2026

NVS

$NVS paying $2bn for Synnovation's SNV4818, after $LLY paid $1.5bn for Scorpion's STX-478. Mechanistically, seems like good news for $RLAY, bad for $OKUR & $COGT

By Jacob Plieth
MRK Unveils PD-1/VEGF Bispecific at AACR26
SocialMar 18, 2026

MRK Unveils PD-1/VEGF Bispecific at AACR26

$MRK's PD-1 x VEGF bispecific reveal, & other key #AACR26 presentations, via @APEXONCO -> https://t.co/ob1eswxCWF $RVMD $AMGN $GILD $BCYC $SDGR

By Jacob Plieth
Correct Lung Target, Yet IMMP’s
SocialMar 13, 2026

Correct Lung Target, Yet IMMP’s

Lung (not head & neck) was the right choice for $IMMP to pursue in phase 3, but it still failed. Stock -89%. Sory via @APEXONCO -> https://t.co/Y1ilGP5Aqq

By Jacob Plieth
Servier's $2.5B DAWN Deal Closes Ojemda Saga
SocialMar 6, 2026

Servier's $2.5B DAWN Deal Closes Ojemda Saga

$DAWN acquisition by Servier for $2.5bn is quite the ending for Ojemda. Who remembers this RAF inhibitor's bizarre & convoluted history? $BIIB $TAK https://t.co/uD5drO9ymr

By Jacob Plieth