Nick Norwitz MD PhD
Oxford PhD and Harvard MD focused on metabolism, cardiometabolic risk, brain aging, and nutrition science.
Key Molecules for Alzheimer’s Prevention: A Deep Dive
Comment “Curious” for the deep dive Today’s letter is a deep dive into the molecules I find most interesting and promising for Alzheimer’s prevention — including several I take myself or recommend to people predisposed to Alzheimer’s disease. This carousel is just a teaser. For the nuance, rationale, and references, check out the full letter. Comment “curious” and I’ll send it along. #alzheimer #brainenergy #brainhealth #ApoE4 #omega3
Eating More Can Still Lead to Fat Loss
⚠️Trigger warning: “I ate more calories and lost fat” is not a claim that I broke thermodynamics. It’s a factual statement: one supported by controlled human studies, advancements basic science, and a more nuanced perspective on fuel partitioning, thermogenesis, and...
7 Years, 700 Mg/dL Cholesterol, Zero Coronary Plaque
🚨New Paper: "Seven Years of 700 Cholesterol Without Coronary Atherosclerosis" After 7 years of ~700 mg/dl cholesterol, 0 mm3 total plaque (soft +calcified) after expert analysis and AI-guided quantification. Open-access paper linked below.
Resistant Starch Cuts Visceral Fat, Yet Responses Vary
Resistant starch has been shown in multiple randomized controlled human trials to reduce visceral fat. Today’s video (link below) dives into the data, and why individual variability in response matters.
One‑Person Crossover Shows Statin May Impair Workouts
Statin vs Placebo: N = 1 Randomized Crossover Study After posting prior content reviewing data on statins and the potential risk of muscle loss, I was flooded with comments from people saying statins "annihilated" their workouts. Now, I know the party...
Memory Loss Can Spread via Gut Microbiome
Comment “curious” for the deep dive Memory loss might be… infectious. A new Nature study found that when young mice live with older mice that have poor memory, the young mice begin to lose memory too. The natural question is: why? The answer lies...
Self‑Experiment Shows High‑Dose Statins May Reduce Exercise Performance
1/2) Given emerging literature I decided to test, in a randomized, placebo-controlled crossover experiment conducted on myself whether high-dose statins would impair my exercise performance.
High-Dose Vitamin C May Slow Aging, Study Finds
New research in Cell Metabolism suggest high-dose vitamin C might slow aging👇 (details in comments)
GLP‑1 Drugs Don’t Disproportionately Reduce Functional Muscle, DXA Misleads
1/2) New research suggests GLP-1 weight loss drugs probably do NOT cause disproportionate loss of functional lean muscle. The confusion has arisen from the fact that DXA scans capture and pool a lot of different organs and tissues into the category...
Low HRV Significantly Increases Heart Attack and Death Risk
1/2) Heart rate variability (HRV). You’ve probably heard of it—but do you actually understand it? It’s incredibly important metric. Low HRV is associated with ~50% higher risk of heart attack, even after accounting for common confounders. And... In people who’ve already had...
Vitamin C May Halt Aging for Just Cents Daily
Vitamin C for Anti-Aging? New 2026 Science (Human and Monkey) 1/2) Could you really slow aging for as little as 6.2 cents per day? Based on new human and primate data published in Cell Metabolism, it might actually be possible. TL;DR: Vitamin...
Your N=1 Outweighs Any Randomized Controlled Trial
Your N = 1 is more relevant to you than any RCT will ever be.
Ezetimibe Shows Unexpected Potential to Prevent Alzheimer’s
Ezetimibe might help prevent Alzheimer's disease... but not in the way that you think. These data really caught me off guard. But the data are the data. (long-form video linked below)
New GLP‑3 Drug Reta May Target Fat, Spark Hunger
Like it or not, GLP-1-based weight loss drugs are here to stay. 1/2) What's more, people are experimenting with newer evolutions, like "reta" (retatrutide/GLP-3). As an MD PhD & metabolism scientist, I decided to start my own experiment to help answer...
Ketogenic Diet May Counteract Genetic Lp(a) Vascular Damage
Can you fix Lp(a) With Diet? Let's go inside the artery... 1/2) Lp(a) is a genetically determined risk factor for cardiovascular disease. But that doesn't mean you can't change your risk. In today's deep-dive video (21 minutes, just released and linked...