Prophylactic IOPIDINE Cuts Post‑Surgery IOP Spikes 91%
$HROW A J-code makes Medicare reimbursement routine. "indicated to control or prevent post-surgical elevations in IOP that occur in patients after argon laser trabeculoplasty, argon laser iridotomy or Nd:YAG posterior capsulotomy" "Prophylactic use of IOPIDINE 1% has been shown to reduce severe IOP spikes from approximately 23% in untreated patients to approximately 2% — a roughly 91% relative risk reduction."
Fresnel Lens Heats Rocks, Drives Simple Stirling Generator
Pretty amazing if it works - concentrate sunlight with movable fresnel lens to heat rocks to 1000 degrees C and then a simple Stirling engine to generate power. Nothing that couldn’t have been built a century or more ago.
Consumer Pessimism Stems From Perceived Price Pressures, Not Fundamentals
Excellent article attempting to explain why consumer sentiment is so bad (worst ever) while objective prices, wages, employement and economy are all fairly stable: "It's the prices, stupid" https://t.co/bqHARTz5JM
Two‑Month Dosing Likely Beats Monthly in PK Trial
As I commented before, they have Phase 2 PK data and they still took both 2 months and 3 months into Ph 3. The primary endpoint is purely a PK non-inferiority one (AUC through week 24). That means that 2...
People Actually Google Tanker Trucks for Oil Pickups
LoL. Someone googling right now about where to get a tanker truck to pick up their oil ...
Relative, Performance‑linked Awards Beat Stock Options in Downturns
Restricted stock is essentially deferred cash. Options are fine for employees when everything is going up; not so much when there is a downturn. The best compensation device by far is a relative award linked to how well your stock price...
B12‑producing Gut Microbes Linked to Colorectal Cancer Progression
Some interesting nuggets in this study which found microbiome subspecies prevalence associated with colorectal cancer (CRC). And one highly associated subspecies makes Vitamin B12. "Interestingly, higher concentrations of B12 are measured in the serum of CRC patients, and these B12 levels...
Acting CDC Chief Stalled Release of Vaccine Benefit Study
Acting CDC director delayed release of study showing benefit of Covid vaccines - NBC News https://t.co/JsxUVy7Cpj
Amazon's Letter Reveals 1M Robots, Chip Strategy
The $AMZN shareholder letter is a must read. Market grumbles about capex until it figures out what they are building. Incidentally 1 million robots already at work. But their new chip stuff is key. https://t.co/DeULJAN7Dg
LP(a)-Lowering Drugs Poised as Pharma’s Next Breakthrough
The next big thing in pharma over the next few years - drugs to reduce LP(a). https://t.co/2rmLcAFGp1
Brains Overproduce Synapses, Then Prune Through Adolescence
Interestingly, the way human brains develops is to start with too many synapses (a 2 or 3 year-old has about double the number of of an adult) followed by rapid pruning in adolescence, with pruning tapering off in the 20's.
Α‑Eleostearic Acid Acts as Senolytic via Ferroptosis
α-eleostearic acid as a senolytic via ferroptosis. Found in high concentrations in Tung oil (which is toxic) and in small amounts in Bitter Melon oil. https://t.co/FSCix3OZtD
Anthropic Tests Claude Mythos Rigorously; Others May Follow
Anthropic putting Claude Mythos through its paces before releasing it. But will other leading-edge companies do the same?
Claude Gains Full Access to Microsoft Apps—Use Cautiously
Meantime Claude can now interact with all the Microsoft applications. Not that I would let it do so just yet ...
Read John Scalzi's Redshirts—A Must‑Read for Twitter Fans
LoL. If you haven't yet read Redshirts by John Scalzi (who used to post on Twitter but left) you should.
