Prioritizing Human‑Focused Drug Development Over Mouse Experiments
“Our goal at Strand, and our challenge, is building drugs today that impact patients’ lives. We’re not a research institute. Our goal is not to do really cool research on mice and join the ranks of people who have cured mice of cancer. There’s millions of them. There could be a Nobel Prize every five minutes for someone who’s cured a mouse of cancer. Our goal is to cure human beings of human-being cancer. Our goal is to cure human beings of human-being diseases, and do so in a safe, effective, scalable way that impacts a person’s life as little as possible. And that is what we’re building.” — Jacob Becraft (@DrSynbio) Listen to my brand-new conversation with Jake Becraft of @StrandTx here: https://t.co/Lx6FiwYntM
Micro‑Progressions Unlock Extraordinary Change for Neurodiverse Athletes
NEW podcast episode is up! The Most Incredible Transformation I’ve Ever Seen — Jerzy Gregorek on Autism, Cerebral Palsy, Coaching, and the Power of Micro-Progressions Jerzy Gregorek (@TheHappyBody) is a 4x World Weightlifting Champion, co-founder of UCLA’s weightlifting team, and co-creator, with...
Being Authentic Makes Life Simpler
“When I decided on the right to be who I truly was, instead of the person I had always agreed and striven to be—i.e., highly successful, endlessly charming—life got a lot more simple.” — @ANNELAMOTT Listen to the latest episode of...
Find Inner Calm Amid Life’s Constant Rush
“The very secret of life for me, I believed, was to maintain in the midst of rushing events an inner tranquility.” — Margaret Bourke-White
Celebrate Moments of Happiness with a Simple Affirmation
“I urge you to please notice when you are happy, and exclaim or murmur or think at some point, ‘If this isn't nice, I don't know what is.’” — Kurt Vonnegut
One Sentence, One Clear Product Benefit
The main benefit of your product should be explainable in one sentence or phrase. How is it different and why should I buy it? ONE sentence or phrase, folks. Apple did an excellent job of this with the iPod. Instead...
Industry Success Demands Relocating to Its Geographic Hub
"The single most important thing for anybody wanting to break into any industry is go to the headquarters or cluster of that industry. Move to wherever that thing is. And all the advice that you can do anything from anywhere...
AI Race Fuels Massive Value, Rewards Top Talent
"We're in one of the most important technology races of all time. The faster that we get to better and better AI, the more economic value will effectively show up. And, therefore, people are really willing to pay in an...
Never Stop Being Astonished: Lifelong Learning in Art
“What I feel fortunate about is that I’m still astonished, that things still amaze me. And I think that that’s the great benefit of being in the arts, where the possibility for learning never disappears, where you basically have to...
AI Founders Must Confront These Critical Self‑assessment Questions
Elad Gil on the tough questions AI founders need to ask themselves right now. @eladgil https://t.co/6XpxEoKDNy
Success Hinges on One Core Belief About a Company
"Often these things boil down to one single question: What is the one thing I need to believe about this company that makes me think it's going to continue to be really big? Usually, it's one thing. If it's three...
Your Response Matters More than Any Setback
“Bad things happen to everybody. It’s not about the bad decision you made or the bad thing that happened to you; it’s what you do after that.” — Cathy Lanier Listen to my interview with Cathy Lanier: https://t.co/zxvxzw4szM
Winning Requires Relaxed Concentration, Not Over‑Trying
Books are my go-to distraction when submerged in ice baths for a testicle-punishing 10 to 15 minutes. One night, the flavor du jour was The Inner Game of Tennis by W. Timothy Gallwey. One passage stopped me in my tracks a...
Know When Not to Answer: Essential in Crisis
“To learn which questions are unanswerable, and not to answer them: this skill is most needful in times of stress and darkness.” — Ursula K. Le Guin
Optimism Drives Progress; Pessimism Holds Humanity Back
“The test of all beliefs is their practical effect in life. If it be true that optimism compels the world forward, and pessimism retards it, then it is dangerous to propagate a pessimistic philosophy.” — Helen Keller, Optimism