19 Health Systems Partnering with Amazon One Medical — and Where Each Relationship Stands

Why It Matters

The expanding One Medical ecosystem gives Amazon a foothold in primary and specialty care, enhancing its health‑service portfolio and creating a seamless, tech‑enabled patient experience. For health systems, the partnership offers access to Amazon’s digital infrastructure and a broader patient base, reshaping regional care delivery dynamics.

Key Takeaways

• One Medical now partners with 19 health systems across 12 states
• Amazon Pharmacy kiosks launched in LA One Medical offices 2025
• Cleveland Clinic co‑brands new One Medical clinics in Northeast Ohio
• Mount Sinai retains Brooklyn/Queens; Montefiore takes Manhattan 2026
• Specialty referrals cover major metros from Dallas to Seattle

Pulse Analysis

Amazon’s acquisition of One Medical has turned a niche primary‑care brand into a strategic conduit for the e‑commerce giant’s health ambitions. By weaving One Medical into its Prime ecosystem, Amazon offers members streamlined appointment scheduling, virtual visits, and now in‑office pharmacy pick‑ups via Amazon Pharmacy kiosks. This integration not only leverages Amazon’s logistics expertise but also positions the company as a direct competitor to traditional health‑system networks, accelerating the convergence of retail and clinical services.

The partnership roster illustrates a deliberate geographic spread, linking One Medical’s eight‑clinic footprint in Chicago to Rush University System for Health, while in the Southeast, Ascension Seton and Baptist Health South Florida provide specialty referrals. Recent co‑branding deals, such as Cleveland Clinic’s new offices in Avon and Shaker Heights, underscore a trend toward joint branding that blends One Medical’s tech‑forward model with established hospital reputations. For patients, the benefit is a smoother transition from primary to specialty care, often within the same digital platform, reducing referral friction and improving continuity.

Industry analysts view this expanding network as a catalyst for broader disruption. Health systems gain access to Amazon’s data analytics, supply‑chain efficiencies, and a massive consumer base, while Amazon secures a credible clinical partner network to support its long‑term health‑service ambitions. As more systems join or deepen ties, the competitive pressure on standalone primary‑care providers intensifies, prompting further consolidation and innovation in telehealth, value‑based contracts, and patient‑centric care models. The trajectory suggests a future where Amazon‑backed clinics become a standard entry point for millions of Americans seeking integrated, tech‑enabled health services.