Lecture 3.2.5: Signal Preprocessing ECG, PPG + Feature Extraction, Windowing & HRV Spectral Features

Universal Digital Health
Universal Digital HealthMay 7, 2026

Why It Matters

Robust preprocessing transforms noisy biosignals into trustworthy HRV metrics, directly influencing patient monitoring, wearable health analytics, and performance‑optimization decisions.

Key Takeaways

  • Raw ECG/PPG signals require multi-stage preprocessing to extract insights
  • Notch, high‑pass, low‑pass filters remove power line, baseline, EMG noise
  • Band‑pass (0.5‑40 Hz) and zero‑phase filtering preserve R‑peak timing
  • Sliding windows with overlap enable continuous HRV analysis across long recordings
  • RMSSD metric reflects autonomic balance; high values indicate recovery, low stress

Summary

The lecture walks through converting raw ECG and PPG voltages into actionable physiological metrics, focusing on preprocessing, feature extraction, and heart‑rate‑variability (HRV) spectral analysis.

Aksha outlines three dominant noise sources—power‑line interference, baseline wander, and EMG artifacts—and recommends a “Goldilocks” filter chain: notch for 50/60 Hz spikes, high‑pass for low‑frequency drift, low‑pass for high‑frequency muscle noise, and a 0.5‑40 Hz band‑pass with zero‑phase forward‑backward filtering to preserve R‑peak timing.

Using a bread‑slicing analogy, the talk describes windowing long recordings into 30‑second segments with 5‑second overlaps to avoid edge loss. The Pan‑Tompkins algorithm (differentiation, squaring, integration) is demonstrated in Python with NumPy, Matplotlib and SciPy on a synthetic ECG contaminated by 50 Hz line noise and baseline wander.

Accurate preprocessing enables reliable extraction of R‑peak intervals and HRV indices such as RMSSD, which differentiate sympathetic stress from parasympathetic recovery. These metrics underpin wearable health monitors, ICU patient tracking, and sports‑science training programs, making robust signal pipelines a prerequisite for clinical and commercial applications.

Original Description

In Lecture 3.2.5 of the Masters in Health Data Science, we explore how raw biomedical signals are transformed into meaningful clinical insights.
This session walks through the complete pipeline—from noisy electrical signals to actionable physiological metrics like Heart Rate Variability (HRV).
🔬 What you’ll learn:
• ECG vs PPG: Electrical vs Optical signal acquisition
• Understanding the QRS complex and systolic peaks
• Common noise sources in biosignals:
• Power line interference (50/60 Hz)
• Baseline wander
• EMG (muscle) artifacts
• Signal preprocessing techniques:
• Band-pass filtering
• Notch filtering
• Zero-phase filtering
• Windowing & segmentation strategies for time-series data
• Feature extraction using R-peak detection (Pan-Tompkins algorithm)
• RR intervals and heartbeat timing analysis
• HRV (Heart Rate Variability):
• RMSSD, SDNN, LF/HF ratio
• Sympathetic vs Parasympathetic nervous system
• Hands-on Python implementation using:
• NumPy
• SciPy
• Matplotlib
• NeuroKit
📊 By the end of this lecture, you’ll understand how to:
• Clean noisy ECG signals
• Detect heartbeats accurately
• Extract meaningful features
• Convert signals into clinically relevant insights
💡 Key takeaway: Raw biosignals are meaningless without proper preprocessing and feature engineering—this pipeline is the foundation of wearable health tech, ICU monitoring, and digital diagnostics.
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