![[Comment] Life at the Water's Edge: A Lancet Commission on Sea-Level Rise, Health, and Justice](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/f7b862f66dee1270bd326b6a9b7e8859.webp?width=1200&resize=contain&quality=75)
[Comment] Life at the Water's Edge: A Lancet Commission on Sea-Level Rise, Health, and Justice
The Lancet Commission’s latest comment warns that accelerating sea‑level rise will reshape daily life for hundreds of millions, with up to 410 million people projected to live below the high‑tide line by 2100. It details how rising waters amplify disease transmission, flood‑related injuries, food insecurity, and eco‑anxiety, while eroding cultural and ecological foundations of health. The analysis stresses that sea‑level rise rarely acts alone, merging with other climate hazards to create cascading, life‑course vulnerabilities. The authors call for justice‑oriented policies that address these intertwined risks.
![[Correspondence] Suicidal Crisis: First Regulatory Approval of IV Racemic Ketamine](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/9ee5b606511aef98e3b5be5706cf97fd.webp?width=1200&resize=contain&quality=75)
[Correspondence] Suicidal Crisis: First Regulatory Approval of IV Racemic Ketamine
In March 2026 France became the first country to grant regulatory approval for intravenous racemic ketamine as a treatment for adult severe suicidal crisis. Clinical trials have shown that a single 0.5 mg/kg infusion over 40 minutes can blunt suicidal ideation...
![[Correspondence] War Economies and Collapsing Health Systems](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/31a5ed334e84c2f1fa642b1da003e946.webp?width=1200&resize=contain&quality=75)
[Correspondence] War Economies and Collapsing Health Systems
Rising defence budgets are crowding out public health financing, with a 1 % increase in military spending cutting health budgets by 0.62 % globally and 0.96 % in low‑income nations. Conflict‑related destruction, supply‑chain blockades and sanctions have already caused tens of millions of...
![[Correspondence] Cancer, Climate Change, Fossil Fuels, and War: A Call for Action](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/5c188eba14ae6153b256f9c474d09bfe.webp?width=1200&resize=contain&quality=75)
[Correspondence] Cancer, Climate Change, Fossil Fuels, and War: A Call for Action
Nancy Krieger’s correspondence highlights a growing body of research linking climate change to cancer, while exposing a glaring gap in accountability for fossil‑fuel‑driven wars. The article cites recent studies on pollution, occupational exposures, and climate refugees, and draws attention to...
![[Correspondence] Sound Mind, Sound Place: Ibasho and Post-Disaster Mental Health](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/8605818caa7c5d4c136c9bacd704ce51.webp?width=1200&resize=contain&quality=75)
[Correspondence] Sound Mind, Sound Place: Ibasho and Post-Disaster Mental Health
The correspondence argues that post‑disaster mental health must move beyond acute symptom checklists toward community‑based recovery, highlighting Japan’s *ibasho*—a locally‑led place that embeds individuals in social networks and meaningful roles. Data from the 2011 Great East Japan Earthquake show that...
![[Comment] Targeted Advertising in Generative Artificial Intelligence Chatbots: A New Public Health Risk](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/26ba616f3e3f2861b999eb892835dbac.webp?width=1200&resize=contain&quality=75)
[Comment] Targeted Advertising in Generative Artificial Intelligence Chatbots: A New Public Health Risk
OpenAI announced it will embed targeted advertising in the free and low‑cost versions of ChatGPT, pairing the rollout with safeguards such as ad‑response separation, privacy protections, age gating for users under 18, and limits on health‑related ads. The move addresses...
![[Comment] Rethinking Country Classifications Towards a More Equitable Global Health Future](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/4b3ad670d67640fd05398f327e60ff90.webp?width=1200&resize=contain&quality=75)
[Comment] Rethinking Country Classifications Towards a More Equitable Global Health Future
The authors argue that the World Bank’s income‑based country classification, which groups nations into low, middle and high income based on gross national income per capita, no longer reflects health system realities. They show that income alone masks profound heterogeneity...
![[Articles] Deferral of Percutaneous Coronary Intervention in Patients Undergoing Transcatheter Aortic Valve Implantation (PRO-TAVI): An Investigator-Initiated, Multicentre, Open-Label, Non-Inferiority, Randomised...](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/8dd390416dac9e7c7ef535f096fc2680.webp?width=1200&resize=contain&quality=75)
[Articles] Deferral of Percutaneous Coronary Intervention in Patients Undergoing Transcatheter Aortic Valve Implantation (PRO-TAVI): An Investigator-Initiated, Multicentre, Open-Label, Non-Inferiority, Randomised...
The PRO‑TAVI investigator‑initiated trial randomised 466 patients with coronary artery disease undergoing transcatheter aortic valve implantation to either deferred percutaneous coronary intervention (PCI) or PCI before TAVI. At one year, the composite of all‑cause mortality, myocardial infarction, stroke and major...
![[Comment] Coronary Revascularisation Before TAVI](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/251af1f3d57165e164ea77b88b1b1714.webp?width=1200&resize=contain&quality=75)
[Comment] Coronary Revascularisation Before TAVI
Coronary artery disease affects up to half of patients referred for transcatheter aortic valve implantation (TAVI), raising the question of whether routine percutaneous coronary intervention (PCI) before valve replacement improves outcomes. The PRO‑TAVI trial, a multicenter non‑inferiority randomized study, compared...
![[Articles] Aspirin versus Clopidogrel for Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention: 10-Year Follow-Up of the HOST-EXAM Trial](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/f4390aa942546562889e73ef6cd4e624.webp?width=1200&resize=contain&quality=75)
[Articles] Aspirin versus Clopidogrel for Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention: 10-Year Follow-Up of the HOST-EXAM Trial
Ten‑year extended follow‑up of the HOST‑EXAM trial compared clopidogrel 75 mg daily with aspirin 100 mg daily as chronic monotherapy after PCI. Among 5,438 patients, clopidogrel achieved a 25.4% incidence of the composite of death, MI, stroke, ACS readmission, or major bleeding...
![[Comment] Moving Beyond Aspirin After Percutaneous Coronary Intervention: 10-Year Results From the HOST-EXAM Trial](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/8acb026fc2949304b649926f35a196b8.webp?width=1200&resize=contain&quality=75)
[Comment] Moving Beyond Aspirin After Percutaneous Coronary Intervention: 10-Year Results From the HOST-EXAM Trial
The HOST-EXAM trial, with ten-year follow‑up, compared clopidogrel monotherapy to aspirin after percutaneous coronary intervention. Results showed clopidogrel achieved lower rates of major adverse cardiovascular events and major bleeding. The study enrolled over 5,000 patients from diverse centers, reinforcing the...
![[Therapeutics] Pyruvate Kinase Activators in Hereditary Haemolytic Anaemias: Current Evidence and Clinical Potential](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/8c90dd45d33f73eeff78aead96a79a6a.webp?width=1200&resize=contain&quality=75)
[Therapeutics] Pyruvate Kinase Activators in Hereditary Haemolytic Anaemias: Current Evidence and Clinical Potential
Hereditary hemolytic anemias affect millions worldwide and have few disease‑modifying options. Oral pyruvate kinase activators, especially mitapivat, increase glycolytic ATP production, correcting a common metabolic defect in red cells. Clinical trials have shown efficacy in pyruvate kinase deficiency, sickle cell...
![[Perspectives] Bill Foege: Building Global Health Coalitions with Compassion](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/c8d08700ef09b2c0504934249079ae30.webp?width=1200&resize=contain&quality=75)
[Perspectives] Bill Foege: Building Global Health Coalitions with Compassion
Bill Foege, the American epidemiologist who helped eradicate smallpox, died on Jan 24 2026. His career was defined by building global health coalitions grounded in compassion, scientific rigor, and relentless optimism. Colleagues like David Heymann recall his mentorship and gentle yet visionary...
![[Perspectives] Cancer in Pregnancy: Navigating Two Medical Systems](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/677a5ada881d0c9455b4c33ce2ea6cb9.webp?width=1200&resize=contain&quality=75)
[Perspectives] Cancer in Pregnancy: Navigating Two Medical Systems
A 37‑year‑old woman was diagnosed with triple‑negative breast cancer with lymph‑node metastasis at 29 weeks pregnant. Treated within Australia’s high‑standard health system, she faced the dual challenge of oncology and obstetric care. The piece highlights systemic complexities when cancer intersects...
![[Correspondence] Call to Enhance Civilian and Military Blood Preparedness](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/3cdceb7aa0991549fda94f4aa2ac80de.webp?width=1200&resize=contain&quality=75)
[Correspondence] Call to Enhance Civilian and Military Blood Preparedness
In February 2026 the NATO Blood Panel met in Brussels and issued a correspondence urging both military and civilian blood services to improve surge capacity for future conflicts and crises. The authors note that whole blood, especially low‑titer O, is...