David Sinclair
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Harvard genetics professor and longevity researcher, author of 'Lifespan'; a leading voice on anti-aging science and biotech breakthroughs.
Recent Posts
Social•Feb 20, 2026
Exercise‑induced Liver Enzyme GPLD1 Restores Memory, Boosts Vascular Health
Liver enzyme GPLD1 produced during exercise reverses aging- and Alzheimer’s-related memory loss by improving vascular health https://www.cell.com/cell/fulltext/S0092-8674%2826%2900111-X
By David Sinclair
Social•Feb 19, 2026
Reversing Nerve Cell Age to Combat ALS, Alzheimer’s
Super proud of Dr. Kelly Rich, senior postdoc in our lab who's pioneering nerve cell epigenetic age reversal to treat diseases such as ALS and Alzheimer's 🪨⭐️ https://open.spotify.com/episode/7nWkEH5li36oW9monEIG8B
By David Sinclair
Social•Feb 18, 2026
Resveratrol Activates SIRT1 to Shield Kidneys From Fat
Resveratrol protects kidneys from fat accumulation and diabetic kidney disease by activating SIRT1, similar to its effects on fatty liver 🐁 www.sciencedirect.com/science/article/abs/pii/S1098882326000067
By David Sinclair
Social•Feb 17, 2026
PRC2 Links Embryonic Methylation to Age Reversal
Embryos and old people have a lot in common: the PRC2 protein complex, which controls DNA methylation during embryogenesis, is a key participant in age reversal via epigenetic reprogramming link.springer.com/content/pdf/10.1038/s44320-026-00195-9.pdf
By David Sinclair
Social•Feb 7, 2026
FDA Clears First Human Cellular Reprogramming Trial
Fascinating interview with Chief Scientist Sharon Rosenzweig-Lipson about working with the FDA, prepping for clinical trials, and what's next lifespan.io/news/first-human-cellular-reprogramming-trial-cleared-by-the-fda/
By David Sinclair
Social•Feb 1, 2026
Blood Biomarkers Reveal Cardiometabolic Risk Beyond Weight
New Cardiometabolic clock identified blood biomarkers that associate with disease and early death. While body weight seemingly wasn't a major determinant, these were: HbA1c, creatinine, lymphocyte %, urea nitrogen, RDW, pulse & systolic blood pressure
By David Sinclair
Social•Jan 31, 2026
FDA Greenlights Human Trials for Epigenetic Age Reversal
Story in @fortunemag today about FDA's approval to test epigenetic age reversal in humans www.tinyurl.com/mvyzds8z
By David Sinclair
Social•Jan 29, 2026
Team Achieves Safe Age‑Reversal Breakthrough at LiFE BIOSCIENCES
Meet the LiFE BIOSCIENCES team, from L to R, Dr. Michael Ringel (COO), Dr. Sharon Rosenzweig-Lipson, (CSO) and Jerry McLaughlin (CEO). Not pictured Amit Shashank (CAO) and my co-founder and founding CEO, Tristan Edwards. A shout out to my lab...
By David Sinclair
Social•Jan 28, 2026
Chris Petty Advances Cell Age Reset, ER‑100 Trials Near
PhD student Chris Petty presents his latest results to the lab. His project is to uncover the mystery of how it’s possible to reset the age of a cell. Where does the back up lie? It’s one of the biggest...
By David Sinclair
Social•Jan 27, 2026
Continuous Glucose Sensor Outperforms HbA1c in Predicting Disease
Continuous glucose sensor (GGM) foundation model predicts Type 2 diabetes and cardiovascular deaths better than the standard blood biomarker, HbA1c
By David Sinclair
Social•Jan 25, 2026
New Study Shows Telomeres Reset in First Week
Did you know that we begin life the same age as our parents? Then during the first week of life we undergo a reset. A new study has just mapped how telomeres are also reset during this process https://academic.oup.com/reproduction/article/171/1/xaaf005/8424158
By David Sinclair
Social•Jan 24, 2026
Consistent Sleep Beats Length in Predicting Mortality
Sleep regularity appears to be a stronger predictor of mortality risk than sleep duration https://elifesciences.org/articles/88359
By David Sinclair