David Sinclair
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Harvard genetics professor and longevity researcher, author of 'Lifespan'; a leading voice on anti-aging science and biotech breakthroughs.
Recent Posts
Social•Jan 20, 2026
Longevity Biotech Shifts Focus to Root Causes
Longevity biotech now targets root causes rather than single diseases. This is a paradigm shift in medicine
By David Sinclair
Social•Jan 19, 2026
DNA Breaks Speed Aging; Cloning Reveals Epigenetic Loss
Introducing controlled DNA breaks accelerates biological aging without mutations, and animals can be cloned from old adult cells, suggesting aging is caused by information loss at the epigenetic level
By David Sinclair
Social•Jan 18, 2026
Low Air Pressure Clears Senescent Cells, Extends Mouse Lifespan
Intermittent bouts of low air pressure prevent hair loss, weight gain, osteoporosis, and extend the lifespan of mice. Ascribed to selective lysosomal killing of senescent cells. Could aerobic exercise or high altitudes mimic this effect? 🧵 https://doi.org/10.1038/s41551-025-01584-5
By David Sinclair
Social•Jan 18, 2026
MEK Inhibitor Trametinib Boosts
Trametinib is an approved drug for melanoma. It inhibits MEK1/2 thereby shifting cells away from “grow at all costs” to maintenance & repair🐁Trimetaprib extends lifespan ~15% & with rapamycin a whopping 30%
By David Sinclair
Social•Jan 16, 2026
Inflammation Speeds DNA Methylation Aging, Impairing Cognition
Systemic inflammation is associated with cognitive impairment. New paper suggests this relationship is caused by an acceleration of DNA methylation age https://www.tandfonline.com/doi/full/10.1080/17501911.2025.2595905
By David Sinclair
Social•Jan 16, 2026
Sequencing Boom Drives Quantity over Quality in Biology Publishing
Anyone else feel that since next-gen sequencing and bioinformatics, publishing a paper in biology has become increasingly about quantity than quality?
By David Sinclair
Social•Jan 16, 2026
Longevity Demands Whole‑Life Habits, Not One Simple Fix
I’m often asked what the one thing to increase longevity. If it were that simple, many more people would already live to 100 Here are some tips: 1. Avoid sugar, simple carbs, alcohol 2. Lose your breath for 10 min 3x/week...
By David Sinclair
Social•Jan 14, 2026
Low SIRT1 and Cholesterol Link Depression; NAD⁺ May Help
New mouse study shows cortisol, inflammation, and low SIRT1 activity all lead to depression caused by reduced neuronal cholesterol. Could statins exacerbate? And since SIRT1 is NAD⁺-dependent, could NAD⁺ boosting help treat depression?
By David Sinclair
Social•Jan 14, 2026
Spaceflight Triggers Temporary Epigenetic Aging, Then Reversal
Space could be a testing ground for age reversal elonmusk. In 4 astronauts, epigenetic age of blood cells rose ~2 yrs by day 7 of orbit & returned to normal (or even younger) upon return 🚀 🌎 mason_lab @davefurman onlinelibrary.wiley.com/doi/10.1111/acel.70360
By David Sinclair
Social•Dec 31, 2025
Pain‑free Surgery Once Seemed Impossible, Now It's Reality
If restoring youthful function in old tissues sounds radical, remember that surgery without pain once did to
By David Sinclair