David Sinclair
Harvard genetics professor and longevity researcher, author of 'Lifespan'; a leading voice on anti-aging science and biotech breakthroughs.
Calorie Restriction Cuts Human Biological Aging by 2‑3%
Slowing aging is not theoretical. In humans, calorie restriction measurably slows biological aging pace by ~2–3% over 2 years https://www.nature.com/articles/s43587-022-00357-y
Glutamic Acid Boosts Quality of Aged Mouse Oocytes
Supplementation of old female mice with glutamic acid (an amino) enhances the quality of aged oocytes
Epigenetic Reset: Once Mocked,
From 2008-2024 I was accused of hyping (a common slur) for suggesting that changes to the epigenome might cause aging and that therapeutics could "allow us to reset the epigenome to a more youthful state." - Oberdoerffer & Sinclair...
Muscle Mass Predicts Older Adults' Survival Better than BMI
Muscle mass is a stronger predictor of survival than BMI in older adults Read here: https://www.sciencedirect.com/science/article/abs/pii/S0002934314001387
Prioritize Performance; Longevity Follows as a Bonus
The goal isn’t longer life.�It’s longer function and performance. Longer life is the side effect
Lifespan.com: Underrated Hub for Longevity Research
OMG. I’m getting worried 🙈 No one has told me Lifespan.com - with its podcast show, magazine and community to support longevity research - is crazy. 🤔 Anyone?!
Age Spots Linked to Epigenetic Drift, Potentially Reversible
Could age spots be due to a suspected cause of aging? New paper says: "Consistent with the Information Theory of Aging, we found a global disruption of tight epigenetic regulation of methylation states." If so, they are reversible. Can't wait to...
Life Biosciences Celebrates ER-100 Milestone After Eight Years
Congrats Life Biosciences team. Big thanks to our investors. Well done Jerry McLaughlin, Michael Ringel, Amit Shashank, Sharon Rozenzweig-L, Ivan Kaplan, @chefserenapoon & team. Go ER-100🤞 Not sure we qualify as “startup” after 8 yrs & being in the clinic...
Ultra‑processed Foods Tied to Many Chronic Diseases
Large meta-analysis of ultra-processed food intake is linked to multiple chronic diseases, not just obesity�https://www.bmj.com/content/384/bmj-2023-077310
Aging Isn't Destiny—It's a Modifiable Biological Process
Most people treat aging as fate.�Biology treats it as a process that can be changed
Lab Celebrates Progress While Students Head to Grad School
Celebrating another week of amazing progress at the Sinclair lab and farewell to a couple of our beloved students, Yifan and Hanyu, both headed off to graduate school 👩🏻🎓 This morning we had our usual three hour lab meeting, but it...
Exploring Tomorrow's Medicine with Global Leaders at ATOM
So proud to be on stage again with Serena at the ATOM event in LA talking to our dear friends Vartan Sarkissian and his father President Armen Sarkissian of Armenia 🇦🇲 about the future of medicine and healthcare 🧬 ATOM...
Regular Sauna Use Lowers Cardiovascular Mortality Risk
Heat exposure through sauna bathing is associated with reduced cardiovascular mortality. JAMA Internal Medicine, 2015. Laukkanen et al. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2130724
Eight Hours Sitting Increases Mortality—Stand Now
Sitting for over 8 hours daily raises mortality risk. Stand up. Now. (And get a standing desk)
NMN Restores NAD, Shields Heart via SIRT3
According to ITOA, NAD declines with age, causing epigenetic changes & disease susceptibility In 2010, we showed NAD-dependent enzyme, SIRT3, protects the heart 🐁 New study says NAD precursor NMN protects the heart via SIRT3 in mice fed a Western diet https://www.sciencedirect.com/science/article/pii/S0022316626000842