David Sinclair
Harvard genetics professor and longevity researcher, author of 'Lifespan'; a leading voice on anti-aging science and biotech breakthroughs.
Age Spots Linked to Epigenetic Drift, Potentially Reversible
Could age spots be due to a suspected cause of aging? New paper says: "Consistent with the Information Theory of Aging, we found a global disruption of tight epigenetic regulation of methylation states." If so, they are reversible. Can't wait to test it!
Life Biosciences Celebrates ER-100 Milestone After Eight Years
Congrats Life Biosciences team. Big thanks to our investors. Well done Jerry McLaughlin, Michael Ringel, Amit Shashank, Sharon Rozenzweig-L, Ivan Kaplan, @chefserenapoon & team. Go ER-100🤞 Not sure we qualify as “startup” after 8 yrs & being in the clinic...
Ultra‑processed Foods Tied to Many Chronic Diseases
Large meta-analysis of ultra-processed food intake is linked to multiple chronic diseases, not just obesity�https://www.bmj.com/content/384/bmj-2023-077310
Aging Isn't Destiny—It's a Modifiable Biological Process
Most people treat aging as fate.�Biology treats it as a process that can be changed
Lab Celebrates Progress While Students Head to Grad School
Celebrating another week of amazing progress at the Sinclair lab and farewell to a couple of our beloved students, Yifan and Hanyu, both headed off to graduate school 👩🏻🎓 This morning we had our usual three hour lab meeting, but it...
Exploring Tomorrow's Medicine with Global Leaders at ATOM
So proud to be on stage again with Serena at the ATOM event in LA talking to our dear friends Vartan Sarkissian and his father President Armen Sarkissian of Armenia 🇦🇲 about the future of medicine and healthcare 🧬 ATOM...
Regular Sauna Use Lowers Cardiovascular Mortality Risk
Heat exposure through sauna bathing is associated with reduced cardiovascular mortality. JAMA Internal Medicine, 2015. Laukkanen et al. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2130724
Eight Hours Sitting Increases Mortality—Stand Now
Sitting for over 8 hours daily raises mortality risk. Stand up. Now. (And get a standing desk)
NMN Restores NAD, Shields Heart via SIRT3
According to ITOA, NAD declines with age, causing epigenetic changes & disease susceptibility In 2010, we showed NAD-dependent enzyme, SIRT3, protects the heart 🐁 New study says NAD precursor NMN protects the heart via SIRT3 in mice fed a Western diet https://www.sciencedirect.com/science/article/pii/S0022316626000842
Exercise‑induced Liver Enzyme GPLD1 Restores Memory, Boosts Vascular Health
Liver enzyme GPLD1 produced during exercise reverses aging- and Alzheimer’s-related memory loss by improving vascular health https://www.cell.com/cell/fulltext/S0092-8674%2826%2900111-X
Reversing Nerve Cell Age to Combat ALS, Alzheimer’s
Super proud of Dr. Kelly Rich, senior postdoc in our lab who's pioneering nerve cell epigenetic age reversal to treat diseases such as ALS and Alzheimer's 🪨⭐️ https://open.spotify.com/episode/7nWkEH5li36oW9monEIG8B
Resveratrol Activates SIRT1 to Shield Kidneys From Fat
Resveratrol protects kidneys from fat accumulation and diabetic kidney disease by activating SIRT1, similar to its effects on fatty liver 🐁 www.sciencedirect.com/science/article/abs/pii/S1098882326000067
PRC2 Links Embryonic Methylation to Age Reversal
Embryos and old people have a lot in common: the PRC2 protein complex, which controls DNA methylation during embryogenesis, is a key participant in age reversal via epigenetic reprogramming link.springer.com/content/pdf/10.1038/s44320-026-00195-9.pdf
FDA Clears First Human Cellular Reprogramming Trial
Fascinating interview with Chief Scientist Sharon Rosenzweig-Lipson about working with the FDA, prepping for clinical trials, and what's next lifespan.io/news/first-human-cellular-reprogramming-trial-cleared-by-the-fda/
Blood Biomarkers Reveal Cardiometabolic Risk Beyond Weight
New Cardiometabolic clock identified blood biomarkers that associate with disease and early death. While body weight seemingly wasn't a major determinant, these were: HbA1c, creatinine, lymphocyte %, urea nitrogen, RDW, pulse & systolic blood pressure
