
Clinicians Must Decide Now… but SEP-1 Compliance Is Judged After Discharge.
CMS has shifted SEP-1 sepsis bundle performance from a reporting requirement into value-based purchasing, exposing hospitals to payments or penalties based on compliance. National SEP-1 compliance averages roughly 65%, but clinicians face a crucial timing mismatch: they must decide in the emergency department whether to initiate the bundle before definitive sepsis determination. Compliance is assessed after discharge when charts are reviewed, creating pressure to treat broadly to avoid penalties. Speakers call for better rapid diagnostics and decision support to balance timely care with avoiding unnecessary interventions like excess antibiotics.

Payments, Pain, and Pragmatic AI in Clinical Trials - Life Sciences Today Podcast Episode 47
Ledger Run CEO John Chanichi describes his journey from engineering and consulting to building a business platform that streamlines clinical-trial operations, with a particular focus on participant payments, study logistics and data workflows. Ledger Run targets biopharma sponsors and CROs...