Jason Calacanis

Jason Calacanis

Creator
3 followers

first investor in https://t.co/M6cblbFld9 Host: @twistartups @theallinpod; I also invest in 100 startups a year @launch & @founderuni jason@calacanis.com for life

Safe Antidepressant Tapering Amid Unproven Chemical Imbalance Theory
SocialMay 23, 2026

Safe Antidepressant Tapering Amid Unproven Chemical Imbalance Theory

50 million Americans are on antidepressants. 1 in 6 people. Yet the "chemical imbalance" theory that tried to justify remains unproven after 60 years of research. Dr. Mark Horowitz explains how they’re helping patients safely taper off these meds.

By Jason Calacanis
Self‑Driving Cars Near Reality: Engineering, Not Science, Holds Key
SocialMay 15, 2026

Self‑Driving Cars Near Reality: Engineering, Not Science, Holds Key

The day every car becomes fully self-driving is closer than you realize. @wayve_ai CEO, @alexgkendall: The science is done. What's left is engineering. Companies like Wayve, and Tesla, have proven hands-off driving scales. The remaining gap is data, compute, and...

By Jason Calacanis
Uber‑Waabi Partnership Will Triple Global Robotaxi Fleet
SocialMay 15, 2026

Uber‑Waabi Partnership Will Triple Global Robotaxi Fleet

Uber just signed a massive robotaxi deal with @waabi_ai. For context: there are fewer than 10,000 robotaxis in the world today. This one deal would well over triple it with a minimum of 25,000 new robotaxis. Uber provides the demand...

By Jason Calacanis
ADAS Subscriptions Could Unlock $100B Car Market
SocialMay 15, 2026

ADAS Subscriptions Could Unlock $100B Car Market

The self-driving TAM is nuts… 100M cars are produced every year <10,000 robotaxis exist today Only 15% of cars have ADAS (Advanced Driver Assistance Systems) @wayve_ai CEO, @alexgkendall explains, In 5 years, "if you're a manufacturer selling a car that...

By Jason Calacanis
Cerebras IPO Soars: AI Demand or Bubble?
SocialMay 12, 2026

Cerebras IPO Soars: AI Demand or Bubble?

Cerebras just raised its IPO to a valuation at $48.8 billion. The offering has been oversubscribed 20x, and it's the biggest IPO of 2026 so far at a valuation of 71x ARR. Is this sheer insanity, or is the demand...

By Jason Calacanis
AI Spin‑offs Echo Dot‑Com Era Mistakes
SocialMay 12, 2026

AI Spin‑offs Echo Dot‑Com Era Mistakes

OpenAI just spun out a new entity called "OpenAI Deployment Company", a $4B push to help PE firms deploy AI in their portcos. I've seen this movie before. Companies in the dot com era did something similar… Barnes & Noble...

By Jason Calacanis
OpenClaw Usage Plummets; Future Uncertain Amid Competition
SocialMay 11, 2026

OpenClaw Usage Plummets; Future Uncertain Amid Competition

OpenClaw Google searches have been in free fall since March. Token usage is dropping too. So is OpenClaw dead? It feels like the OpenAI acquisition killed the momentum… What do you think? Is OpenClaw gonna win the race? Or are...

By Jason Calacanis
Self‑Driving Cars Could Save 40k Lives; Media Debate Responsibility
SocialMay 11, 2026

Self‑Driving Cars Could Save 40k Lives; Media Debate Responsibility

40,000 Americans die in car crashes every year. Waymo and FSD could prevent most of them. So why isn't the media running a campaign to mandate self-driving? Michael Eisenberg says the press has a moral duty to push life-saving tech....

By Jason Calacanis
Join Us Building in Japan This July
SocialMay 11, 2026

Join Us Building in Japan This July

Headed back to Japan in July, come build with us https://lnkd.in/eBPs926X

By Jason Calacanis
First Rolex? Learn How to Buy Properly
SocialMay 10, 2026

First Rolex? Learn How to Buy Properly

Going to buy my first watch... the @Rolex speaks to me. I need to learn how to buy a new one. Do you just go to the Rolex website or store? educate me please https://t.co/V1NeOZKaxM

By Jason Calacanis
Adopt an AI‑First Mindset: Ask, Automate, Iterate
SocialMay 9, 2026

Adopt an AI‑First Mindset: Ask, Automate, Iterate

J-Cal’s framework for how to be "AI first". It’s not just a slogan. 1. Every task… Ask AI first. “How can I do this better.” 2. Every repeated task… Let your agents take care of it so you can do...

By Jason Calacanis
Whoop Adds Real-Time Doctors, Sparking Healthcare Decentralization Debate
SocialMay 9, 2026

Whoop Adds Real-Time Doctors, Sparking Healthcare Decentralization Debate

The Whoop app is bringing doctors INTO its app so people can chat with a doctor in real time. AND it has access to your health data… While the entire country is arguing over federal healthcare mandates, startups are changing...

By Jason Calacanis
Turn a Layoff Into Revenge: Build Missed Opportunities
SocialMay 8, 2026

Turn a Layoff Into Revenge: Build Missed Opportunities

My playbook for if you’ve been laid off: TAKE YOUR REVENGE. Look at your previous employer. What opportunities did they screw up? Which ones weren’t they taking? What could they have done better? Make 3 different products, see which ones...

By Jason Calacanis
Twitter's Valuable Data Sparks API Cost Tension
SocialMay 7, 2026

Twitter's Valuable Data Sparks API Cost Tension

This is some sick analytics for X -- nicely done @kevinrose Twitter data has always been insanely valuable... which creates a serious tension between adding value to the platform or 3rd party developers... ... what are these APIs costing KRo?!?

By Jason Calacanis
Jason Calacanis | Pulse