AI Predicts Six New Lifespan‑extending Drugs
Can we use machine learning to predict longevity drugs? 💊 In our updated preprint led by @AlekseyVBelikov we trained ML models on compounds in the DrugAge database that extend lifespan in mice. Features associated with longevity drugs included receptors for neurotransmitters, metabolic hormones and sex hormones. We then used our top-performing models to screen DrugBank for new potential longevity drugs. Identified clusters included compounds targeting IGF1 and insulin receptors, beta adrenergic receptors, carbonic anhydrases, dopamine and serotonin receptors. In collaboration with @scrippsresearch we tested 22 predicted compounds in C. elegans and found that 6 of them extended lifespan: dihydroergotamine, mianserin, bromocriptine, voxtalisib, bms-754807 and solifenacine. With our collaborators @UniKent we also created a public web server with our top models. Feedback welcome. https://t.co/6Dm44NqIv4
Promises of Immortality Remain Unfulfilled After 25 Years
Another book on curing aging promised - in 2000 - that science was on the verge of providing physical immortality thanks to genetic engineering, neuroscience, and cloning. A quarter-century later, we're still waiting. Sadly, the author passed away last year. https://t.co/CgSrEvGFnf
One Gene Can Halt Cellular Aging, Hinting at Reversal
Scientists like Hayflick once viewed replicative senescence as a complex, multifactorial form of cellular wear and tear. So when a single gene manipulation (telomerase expression) was shown to prevent replicative senescence, it came as a surprise. Aging is more...
Senescent Cells Misnamed: Time for a New Term
Another impressive study on the physiological functions of senescent cells, another reminder that cellular senescence is a misleading name. What should we call senescent cells instead?
MtDNA Mutations Surge After 60, Unlikely Aging Drivers
Impressive work on mitochondrial DNA mutations with age in blood. However, mutations only appear to accumulate substantially after ~60 years of age. Yet aging occurs earlier, so I don't see these findings supporting the idea that mtDNA mutations are drivers of...
Testing Metformin, Fisetin, Spermidine Boosts Elder Resilience
Excited to collaborate in this clinical trial in healthy older adults 🚀 Three geroprotectors (metformin, fisetin, and spermidine) will be tested for resilience promotion after a three-week intervention. Looking forward to seeing how this study unfolds @InflamAge_UoB @news_ub
AI's Promise in Biomedicine Hinges on Quality Data
AI is transforming our lives and science, but we need to be realistic about both its promise and its limitations. In biomedicine, one major bottleneck remains data. We need more high-quality data to unlock AI-driven advances. It was a pleasure to speak...
New Toolkit Maps Human Ageing Hallmarks for Translation
🔬 Excited to share our new preprint on a translational toolkit for ageing research. We present a multi-modal approach to profile key hallmarks of human ageing, from immune function to mitochondrial activity and mTOR/autophagy. Our aim is to improve standardisation, reproducibility, biomarker...
Consider Renaming Senescent Cells as “Aged” Cells
Good point, we may soon be talking of "aged" senescent cells. Maybe it's time to rename senescent cells?
Aging Science Promising Yet Still Lacks Core Understanding
Aging biology is full of promise, but the reality is that it's still a nascent field. Great to be back at the @MPIAGE speaking with students and researchers about some uncomfortable truths in geroscience: We still don't understand the drivers of aging. And...
Aging Evolves: Unveiling the Longevity Bottleneck Hypothesis
Fantastic video on the evolution of ageing and the longevity bottleneck hypothesis 🚀 Thank you @EonsShow @PBS for the brilliant work 🙏 https://t.co/GjHMlIn3hg
Ageing Forms Gene Network Linking Diseases via Two Pathways
Ageing isn't one disease, it's a network. Excited to share our latest study exploring the genetic links between ageing and age-related diseases 🧬 We show how shared pleiotropic genes connect disease clusters, revealing two distinct genetic architectures: one driven by ageing-related...
UK Healthspan Shrinks; Target Ageing, Not Symptoms
Healthspan is decreasing in the UK. Instead of treating the symptoms of ageing, we should be targeting ageing itself.
Why Aging Solutions Aren’t Scientific Priorities
I've met Laurent, and it's great to see him now focusing on aging. Why isn't solving aging a top scientific priority?
AI Accelerates Longevity Science at London Tech Show
AI is reshaping longevity science faster than ever. At the Health + AI Insiders Tech Show, I'll be discussing how computational biology is transforming our understanding of ageing. 📍 London | 29 April 2026 🔗 Complimentary tickets: https://t.co/4XipXYfWcc