Longevity Enthusiasts Aim to Live Longer for Space Exploration
The number of people in the longevity space who want to extend lifespan so they can explore the stars is surprisingly high.
Age‑and Sex‑Specific Genes Shape Lifespan Trade‑offs
Delighted to have contributed to this new study @Nature on the genetics of ageing and mortality 🧬 Using a large mouse cohort, we uncover age- and sex-specific genetic effects, including trade-offs where variants are beneficial early in life but detrimental later.
Longevity Linked to Ion Transport, Not Cell Division Genes
Why some species age slower than others remains a mystery. This is an impressive analysis of genes linked to longevity evolution in mammals. Genes associated with cell division & DNA repair show negative correlations with lifespan evolution, while positively correlated genes are...
Century of Gains Slows; Future Life Expectancy Uncertain
Life expectancy in high-income countries increased ~50% over the past century, but gains have slowed in recent decades (≈70 in 1975 to ≈80 today in US). What will be the life expectancy in 100 years?
Late‑stage Oral Cocktail Adds 33% Lifespan in Obese Mice
An oral drug combination, including a senolytic (quercetin), NR, urolithin A, and alpha-lipoic acid, extended median remaining lifespan in mice by 33%. Important to note, however, that the mice were fed a high-fat "Western Diet" and the intervention started at 18...
P21⁺TREM2⁺ Macrophages Drive Inflammaging and Liver Disease
Delighted to be part of this study identifying p21⁺TREM2⁺ senescent macrophages as drivers of inflammaging and metabolic liver disease. A fantastic collaboration led by @ACovarrubiasPhD 👏
Electromagnetic Gene Switch Extends Lifespan in Progeroid Mice
Wow, a technique that allows electromagnetic control of gene expression in vivo 🤯 And they tested their system with OSK partial reprogramming, showing it extends lifespan in progeroid mice. In normal mice, they report health improvements and a small reduction in mortality...
Drugs May Slow, but Not Fully Reverse Aging
Just like we can't turn a human into a naked mole rat with drugs (requires too many specific molecular changes), I don't think we will fully reverse ageing pharmacologically. We may be able to slow human ageing with drugs, but reversing...
Data‑Driven Models Essential for Longevity Research
Great to speak at Targeting Longevity 2026 in beautiful Berlin, catch up with old friends, and meet new colleagues. From genomes to systems biology and machine learning, we need robust, data-driven models to understand ageing and identify the most promising interventions....
Disabling Light Sensing Extends Worm Lifespan by 40%
Great study in the bristleworm showing that light perception can regulate lifespan. Disrupting light sensing slows development, prolongs growth and extends lifespan by ~40%. More evidence that aging is not just damage accumulation, but is modulated by developmental processes.
Weight‑loss Drugs Boost Life by Aiding Sick, Not Slowing Aging
Weight loss drugs may increase human longevity but that's because they reduce the mortality of folks at the lower end of the lifespan distribution (i.e., unhealthy individuals), not because they delay the aging process. That's still valuable, but if this is...
AI Model Maps Cell Trajectories Driving Human Aging
Impressive temporal AI model of aging by @GladstoneInst Based on ~175M single-cell transcriptomes, the model predicts drivers of cell trajectories across human aging. Also great that the first author, Javier, trained in our lab. Always rewarding to see our alumni flourish.
Senescent Immune Cells Guard Tissues, Delay Aging
Senescent immune cells protect against damage, inflammation and disease 🤯 In mice, p16-expressing immune cells delay age-related organ deterioration and preserve tissue homeostasis. More evidence of the physiological roles of senescent cells? https://t.co/UtBKDF00P1
Slowing Aging: A Targetable Process for Massive Health Gains
Aging may or may not be classified as a disease, but that’s largely semantics. What matters is that aging is a malleable, targetable biological process, and slowing human aging would result in massive health benefits.
C1ORF112 Validated as Breast Cancer Driver After Early Prediction
Great to see a new work showing that C1ORF112 is upregulated in tumor tissues and that it promotes breast cancer proliferation. We computationally predicted C1ORF112 to be related to cancer back in 2012, and we were the first to study and...
Open Review Flags Flaws in Telomere‑river Longevity Study
The incredible study using "Rivers of telomeres" to rejuvenate tissues and extend lifespan in mice is now undergoing open peer-review. I did a review, pointing out issues with the methods and the lifespan curves. They're looking for more reviewers. https://t.co/KOiR4F85sT
AI and Genomics Target Aging to Combat Chronic Disease
Aging underpins most chronic diseases and remains the biggest challenge to human health. Thank you @carninci for the opportunity to present @humantechnopole on aging, genomics and AI approaches to identify longevity targets and drugs. https://t.co/ysDGHfJeY0
Senolytic Combo Damages Mouse White Matter, Triggers Oligodendrocyte Dysfunction
A combination of senolytics causes neuropathology in mice 👀 Dasatinib and quercetin trigger oligodendrocyte dysfunction and white matter injury in the CNS. Senolytics under more scrutiny? https://t.co/aDosJxeyxS
EU Launches AI‑Driven Fight Against Age‑Related Frailty
There are definitely worse places to discuss frailty, ageing, and using AI to discover drugs that preserve health. Kick off meeting of @EU_Commission UNION Marie Curie programme. https://t.co/BwvoPYj3KC
Building AGI Is Essential to Avoid Imminent Extinction
“If nobody builds it, everyone dies” Nick Bostrom’s latest piece on artificial superintelligence makes the point that, given we are all on course for dying in (by and large) the next few decades, developing a transformative technology like AGI is worth...