Matt Kaeberlein, PhD

Matt Kaeberlein, PhD

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Geroscientist (Dog Aging Project; Optispan); evidence-based takes on rapamycin and mechanisms of aging.

Fund NIH Trials to Validate Unapproved Peptide Safety
SocialApr 7, 2026

Fund NIH Trials to Validate Unapproved Peptide Safety

I thought this was an excellent, balanced article on the current state of unapproved peptides from a safety and regulatory perspective by @AnjeanetteDamon in @propublica https://t.co/DbA8cdvTY5 The fundamental problem is that we don't have quality data on safety or efficacy for...

By Matt Kaeberlein, PhD
Women Need Their Own Longevity Blueprint, Not Male Models
SocialApr 5, 2026

Women Need Their Own Longevity Blueprint, Not Male Models

Women are not “mini-men.” That line from Dr. Jennifer Pearlman MD CCFP NCMP FAARM ABAARM stuck with me from our @Optispan_Inc Podcast conversation—and it sets the stage for a much bigger issue. For decades, medicine and biomedical research have often treated...

By Matt Kaeberlein, PhD
Epigenetic Aging Clocks Lack Reliable Real‑world Accuracy
SocialApr 3, 2026

Epigenetic Aging Clocks Lack Reliable Real‑world Accuracy

This is a thoughtful essay on a new preprint from Raghav Sehgal and Albert Higgins-Chen that’s worth your time. It highlights something we don’t talk about enough: for biological aging clocks to be useful outside of research, they need to...

By Matt Kaeberlein, PhD
Longevity Tests Often Mirror Horoscopes, Not Science
SocialApr 2, 2026

Longevity Tests Often Mirror Horoscopes, Not Science

What if your doctor handed you a report… and it was no more meaningful than a horoscope? That’s the uncomfortable reality we’re facing right now in longevity medicine. When clinicians use unvalidated, non-actionable tests, they are replacing evidence-based medicine with something that...

By Matt Kaeberlein, PhD
Metabolic Health Tops Circadian; Sauna Beats Blueprint
SocialMar 22, 2026

Metabolic Health Tops Circadian; Sauna Beats Blueprint

Some interesting match-ups. Metabolic health is beating circadian optimization by a wide margin. Psilocybin and multivitamin are neck and neck. @bryan_johnson's Blueprint is getting destroyed by sauna.

By Matt Kaeberlein, PhD
Sauna Challenges Bryan Johnson's Million‑Dollar Blueprint in Longevity Showdown
SocialMar 18, 2026

Sauna Challenges Bryan Johnson's Million‑Dollar Blueprint in Longevity Showdown

One of the more interesting matchups in round 1 of Longevity March Madness: Sauna vs. @bryan_johnson's Blueprint. Can the million-dollar protocol upset the favorite, or will it be sent home early? Let the people decide: https://t.co/TBjYekZE8A https://t.co/j986aHGBwp

By Matt Kaeberlein, PhD
Longevity March Madness: Vote for the Top Intervention
SocialMar 13, 2026

Longevity March Madness: Vote for the Top Intervention

Selection Sunday is coming… and the Committee has been hard at work. 🧬 Brought to you by @Optispan_Inc and LongevityTexts, welcome to the first-ever Longevity March Madness. Just like the NCAA tournament, 64 longevity interventions will go head-to-head in a single...

By Matt Kaeberlein, PhD