Brain Aging Isn't Inevitable: Basics Beat Supplements
We talk a lot about brain aging as if it’s inevitable. It’s not. In my latest podcast conversation with @DrRagnar—author of The Stimulated Mind—we unpack what’s actually working for brain longevity and what isn’t. A few takeaways that stood out to me: • The adult brain is far more plastic than most people realize. You can build and maintain function well into your 70s and beyond. • Many of the most effective interventions are not exotic—they’re behavioral: exercise, cognitive challenge, sleep, and metabolic health. • The “3S” framework (Stimulus, Supply, Support) is a useful way to think about brain health as a system—not a supplement stack. • There’s a lot of noise around “brain boosting” tools and supplements. Very little of it holds up to scrutiny. One of the most important points is that we actually have more control over our cognitive trajectory than most people think. But that control comes from consistently doing the basics well—not chasing shortcuts. We also get into: - Whether dementia risk is really rising (the answer is more nuanced than headlines suggest) - What high-performance athletes actually do (and don’t do) for brain health - Why exercise may be the single most powerful tool for neuroplasticity - And where emerging tools like neurostimulation and psychedelics might fit (with a healthy dose of skepticism) If you’re interested in what the science actually says about keeping your brain sharp as you age and want a deeper dive, his new book The Stimulated Mind is worth checking out. 🎧 Listen here: https://t.co/j5eDrgHuIt
Fund NIH Trials to Validate Unapproved Peptide Safety
I thought this was an excellent, balanced article on the current state of unapproved peptides from a safety and regulatory perspective by @AnjeanetteDamon in @propublica https://t.co/DbA8cdvTY5 The fundamental problem is that we don't have quality data on safety or efficacy for...
Women Need Their Own Longevity Blueprint, Not Male Models
Women are not “mini-men.” That line from Dr. Jennifer Pearlman MD CCFP NCMP FAARM ABAARM stuck with me from our @Optispan_Inc Podcast conversation—and it sets the stage for a much bigger issue. For decades, medicine and biomedical research have often treated...
Epigenetic Aging Clocks Lack Reliable Real‑world Accuracy
This is a thoughtful essay on a new preprint from Raghav Sehgal and Albert Higgins-Chen that’s worth your time. It highlights something we don’t talk about enough: for biological aging clocks to be useful outside of research, they need to...
Longevity Tests Often Mirror Horoscopes, Not Science
What if your doctor handed you a report… and it was no more meaningful than a horoscope? That’s the uncomfortable reality we’re facing right now in longevity medicine. When clinicians use unvalidated, non-actionable tests, they are replacing evidence-based medicine with something that...
Metabolic Health Tops Circadian; Sauna Beats Blueprint
Some interesting match-ups. Metabolic health is beating circadian optimization by a wide margin. Psilocybin and multivitamin are neck and neck. @bryan_johnson's Blueprint is getting destroyed by sauna.

Sauna Challenges Bryan Johnson's Million‑Dollar Blueprint in Longevity Showdown
One of the more interesting matchups in round 1 of Longevity March Madness: Sauna vs. @bryan_johnson's Blueprint. Can the million-dollar protocol upset the favorite, or will it be sent home early? Let the people decide: https://t.co/TBjYekZE8A https://t.co/j986aHGBwp

Longevity March Madness: Vote for the Top Intervention
Selection Sunday is coming… and the Committee has been hard at work. 🧬 Brought to you by @Optispan_Inc and LongevityTexts, welcome to the first-ever Longevity March Madness. Just like the NCAA tournament, 64 longevity interventions will go head-to-head in a single...