Intention to Treat: The Race Equation (Teaser)
The teaser introduces “The Race Equation,” a New England Journal of Medicine series that investigates how race is embedded in clinical algorithms used daily in U.S. hospitals. These tools determine everything from organ‑transplant eligibility to ventilator allocation, yet many incorporate race‑based adjustments that systematically lower risk scores for Black patients, influencing life‑or‑death decisions. The series traces the practice to a legacy of pseudoscientific beliefs dating back to Thomas Jefferson and slavery, arguing that the premise that Black bodies differ biologically from White bodies is scientifically unfounded. If unchecked, these biased calculations perpetuate health disparities, prompting calls for clinicians and regulators to strip race from algorithms and rebuild them on objective physiological data.
Meet the Equation
The video investigates how a race‑adjusted eGFR (estimated glomerular filtration rate) formula, introduced in the late 1990s, has systematically over‑estimated kidney function for Black patients, affecting diagnosis and treatment decisions. It traces the origin of the correction factor to...
HFpEF Explained — Living with HFpEF | NEJM
The NEJM video spotlights heart failure with preserved ejection fraction (HFpEF), a condition where the heart muscle contracts normally but fails to relax, leading to fluid buildup and breathlessness. The patient narrator shares a four‑year diagnostic odyssey, emphasizing that early...
Dr. Glaucomflecken Explains: Tenecteplase for Acute Central Retinal Artery Occlusion (TenCRAOS)
The video features Dr. Glaucomflecken reviewing a recent New England Journal of Medicine trial that tested intravenous tenecteplase as an emergency treatment for acute central retinal artery occlusion (CRAO), a sudden, painless loss of vision often seen in older hypertensive...
Spinal Epidural Abscess — Key Points in 90 Seconds
Spinal epidural abscess is a serious infection of the epidural space, most often caused by Staphylococcus aureus. Patients typically experience back or neck pain, fever, and may develop neurologic deficits. Prompt evaluation, usually with MRI, is critical to confirm the...
"Mushrooms" For Depression: New Science | NEJM Clinician
NEJM Clinician reports on a JAMA Psychiatry trial evaluating a single 25 mg dose of psilocybin for treatment‑resistant depression. The double‑blind study randomized 144 patients to psilocybin, a low 5 mg dose, or nicotinamide, aiming to mask allocation. At six weeks, 17 % of...
Images in Clinical Medicine: Vibrio Vulnificus Necrotizing Soft-Tissue Infection
A 74‑year‑old man presented with rapidly worsening wounds on his leg and arm after a laceration in Florida’s Gulf waters, ultimately diagnosed with Vibrio vulnificus necrotizing soft‑tissue infection. The case underscores how exposure to warm, low‑salinity coastal water can...
HFpEF Explained — Prevalence, New Advances, and How to Diagnose | NEJM
The video explains that heart failure with preserved ejection fraction (HFpEF) is becoming the dominant form of heart failure, especially among patients over 65, driven by an aging population and the global rise in obesity and diabetes. While historically under‑diagnosed,...
Images in Clinical Medicine: Bronchial Casts From Inhalation of Forest-Fire Smoke
The video presents a case study of an 87‑year‑old man who developed obstructive bronchial casts after inhaling dense smoke from a multi‑hour forest fire. Physical exam showed diffuse rales without burns; escalating airway pressures prompted flexible bronchoscopy, which visualized black particulate...
Endovascular Therapy for Post-Thrombotic Syndrome (C-TRACT)
The phase 3 C‑TRACT trial compared endovascular therapy plus standard care with standard care alone in patients with moderate or severe post‑thrombotic syndrome (PTS). At six months, the combination reduced PTS severity and improved quality‑of‑life scores. However, the intervention group...
60-Second Journal Club: Randomized Trial of Sedative Choice for Intubation
The video reviews a multicenter, unblinded randomized trial that compared ketamine with etomidate as induction agents for emergency tracheal intubation in critically ill adults. Conducted across 14 emergency departments and intensive care units in the United States, the study enrolled...
NEJM Clinician: Catheter-Directed PE Treatment: Does It Deliver?
The New England Journal of Medicine reports a multinational randomized trial evaluating catheter‑directed fibrinolysis (CDT) versus standard anticoagulation in patients with intermediate‑risk (sub‑massive) pulmonary embolism. Over 500 participants were assigned to low‑dose, catheter‑delivered clot‑busting therapy or anticoagulation alone, with the...
When No One's Watching
The podcast “When No One’s Watching” asks whether primary care is a problem to solve or a treasure to nurture, using Olympic figure‑skater Alyssa Lou’s self‑directed comeback as a metaphor for clinicians seeking agency and joy. Host Lisa Rosenbomb argues that...
Medical Mystery Solved — The Devil Is in the Details | NEJM
The video walks through a diagnostic odyssey of a 75‑year‑old woman who presented with night sweats, an eight‑kilogram weight loss and new‑onset renal dysfunction. Initial work‑up focused on common causes in seniors—malignancy, vasculitis, infection—while HIV was not on the radar. Laboratory...
Dr. Glaucomflecken Explains: Tecovirimat for the Treatment of Mpox (STOMP/A5418)
The video features Dr. Glaucomflecken reviewing a New England Journal of Medicine study that evaluated oral tecovirimat, an antiviral approved for smallpox, as a treatment for mpox. The randomized, placebo‑controlled trial enrolled adults with presumptive or laboratory‑confirmed clade 2 mpox within...