Sebastian Cocioba

Sebastian Cocioba

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Independent biohacker; runs a home lab (Binomica Labs) sharing DIY biotech experiments and grassroots science.

Plasma Balls Offer New Canvas for Shaping Art
SocialMay 11, 2026

Plasma Balls Offer New Canvas for Shaping Art

Plasma ball as a medium for artistic expression is pretty cool. I hope they include magnets or electromagnets for some plasma shaping. So many ways one can express themselves in art.

By Sebastian Cocioba
Questioning CDC's Current Primer Design Standards and Tools
SocialMay 11, 2026

Questioning CDC's Current Primer Design Standards and Tools

Jokes aside, what's the current CDC protocol for primer design? Are they using Primer3? Are they using a modern thermodynamic model? Still with that GC clamp juju? I keep hearing primer issues being brought up but thats practically solved...

By Sebastian Cocioba
Code Contributions Need Built‑in Robustness, Not Just MVP
SocialMay 10, 2026

Code Contributions Need Built‑in Robustness, Not Just MVP

Force-feeding Claude Code strange edge cases and attack surfaces to consider bc it doesnt seem to spot them automatically will hopefully be ironed out soon. Ideally robustness and hardening should be the default of any code contribution yet it seems...

By Sebastian Cocioba
Biologists Demand $400K+ Salaries for Custom LLM Work
SocialMay 10, 2026

Biologists Demand $400K+ Salaries for Custom LLM Work

Anyone asking biologists to spend time training their custom LLMs need to pay them at least $400K+/yr and significant stake in company. No way in hell is your billion dollar pharma startup gonna short change the engines of your success. Extremely...

By Sebastian Cocioba
Finally, a Seamless Golden Braid Plasmid Editor
SocialMay 10, 2026

Finally, a Seamless Golden Braid Plasmid Editor

This is all I wanted from a plasmid editor: a way to quickly run Golden Braid cloning using parts from my library, with overhang sanity checks. I have not found a single tool that made it this easy. No visual...

By Sebastian Cocioba
Two Weeks Left, SpliceCraft 1.0 Near Completion
SocialMay 10, 2026

Two Weeks Left, SpliceCraft 1.0 Near Completion

Exactly 14 days until I need to finish version 1.0 of SpliceCraft. Racing against my SnapGene annual bill; making gooood progress. 🤖🛠

By Sebastian Cocioba
Building and Flying Your Own Plane: Ultimate DIY Thrill
SocialMay 9, 2026

Building and Flying Your Own Plane: Ultimate DIY Thrill

I love that im not the only weirdo risking it all on tools they made themselves lol. Nothing like the thrill of flying a plane you built from scratch.

By Sebastian Cocioba
AI‑Created Bio Designs Lack Expert Oversight
SocialMay 9, 2026

AI‑Created Bio Designs Lack Expert Oversight

bioslop (noun) - biological molecules and/or designs made by Ai without the oversight or review of a subject matter expert or specialist LLM

By Sebastian Cocioba
Censoring Nuclear Designs Ignores Publicly Accessible Patents
SocialMay 9, 2026

Censoring Nuclear Designs Ignores Publicly Accessible Patents

@p_maverick_b now they wanna sensor nuke design as if the papers and patents are not easily searchable. Same vibe as the agent refusal for bio. This is getting silly...

By Sebastian Cocioba
Building New Tools Is Valid Even When Alternatives Exist
SocialMay 8, 2026

Building New Tools Is Valid Even When Alternatives Exist

I've never been a fan of the argument of "why build y if x already exists?" That's a silly stance to hold. "Why do people keep making new car brands? We got plenty of cars on the road already..." I'm gonna make...

By Sebastian Cocioba
Ensuring Backups Prevent Patch‑induced Data Loss
SocialMay 8, 2026

Ensuring Backups Prevent Patch‑induced Data Loss

Shoring up user data protections to prevent any future updates from nuking plasmid collections or other user input data. Backups and copies of everything. Hardened, sanitized, and secure. My nightmare scenario is for a user to tell me latest patch...

By Sebastian Cocioba
Industrial Microbiome: Affordable Year-Long Service for $75
SocialMay 8, 2026

Industrial Microbiome: Affordable Year-Long Service for $75

Industrial microbiome products are a slept-on sector of the bioeconomy. A year supply for $75. Microbes as a Service. https://t.co/aWyLZ00qMM

By Sebastian Cocioba
Fine‑tuned DNA Model Achieves Precise Basepair
SocialMay 8, 2026

Fine‑tuned DNA Model Achieves Precise Basepair

I spent some time getting the right spacing to accurately model a DNA molecule in basepair length. Almost dialed it in; rotating about its length axis. Will make better :)

By Sebastian Cocioba
Unexpected Blackouts Force Emergency Freezer Battery Backup
SocialMay 6, 2026

Unexpected Blackouts Force Emergency Freezer Battery Backup

Gotta love sudden unannounced neighborhood-wide blackouts. Time to scramble to hook up battery backup to my freezers...

By Sebastian Cocioba