Celebrate First Attempts: Growth Through Courageous Challenges
First times are always special, and always worth celebrating. Great life lesson too, if one jumps the gun; win-win character growth either way. Warms my heart to see folks doing hard things all excited 💚
Extensive Edge‑Case Testing Ensures Plasmid Editor Robustness
Make a heap of edge case detection tests for my plasmid editor, even did emoji-as-input catches, lol. I take robustness and data integrity very seriously so I'm making sure all sorts of edge cases are handled gracefully. I even added...
Binomica
I wish I had more time to do actual biology research (ongoing; slow burn), but in the meantime I'll focus on contributing new tools and methods to the research community. The mission of Binomica Labs is to enable anyone and...
Adding Input Safeguards and Toggle for Non‑Canonical AAs
Mostly to protect the program from broken inputs, but also fun to block shell code in inputs that shouldn't be there. I'll add a special toggle for non-canonnical AA's when the first user of them asks me. Doing some initial...
Selective LLM Regulation Is Performative, Drives Local Adoption
Regulating LLMs for biology but not every other potentially dangerous activity like turning on a gas stove in your home (unintentional fuel-air explosion device) is just performative knee-jerk and will just force people to use local LLMs. AGI soon but not...
Test Everything, Harden Interfaces, Avoid Sloppy Code
To all the vibecoders making tools for real world scientists, please test for edge cases, harden your critical paths, log events, and make your interfaces robust. Test everything. Test often. Manually go into your app and try to break it...
Biology Knowledge Crucial for Debugging Bio‑code Edge Cases
Vibedebuggin and vibehardenin and checking edge cases and making user inputs holy and tracking off-by-one errors that could kill a bioproject and and and... Good thing I know enough biology to test and check and know what matters to users. How...
Plasmid Editor Adds API for AI-Driven Real-Time Editing
A feature I'm working on adding to my plasmid editor is an API for agent work. This lets your favorite Ai do work on the files in your plasmid editor directly, and the results update in your open GUI in...
Explore Nature Freely: Wander, Discover, Belong Anywhere
Anyway, nature is sublime and you can be a part of the conversation of studying it regardless of resources. Exploration is an incredible hobby and application is seldom at the forefront when discoveries are made. Not all who wander are lost.
NIH Could Fund Groundbreaking Research with $2 B Annually
What could the NIH do with an extra $2 billion dollars a year from publisher fees?
Frustrated with Subaru's Clunky Console, Dreaming of Custom Firmware
I wish I could get into the firmware of this. Subaru console app is dismal. Been trying to push this last update for weeks, lol. TUI car computer dreams... https://t.co/iya84z0Yct
Founders Deflect Criticism Instead of Validating Their Product
Why is it that founders these days when confronted with negative feedback always turn to snarky deflection? If a ton of people are saying your work is sus, would it not be prudent to actually check if it is? Unless the...
Finish Vibecoded TUI Editor Before SnapGene Expires
I am challenging myself to make enough progress on my vibecoded TUI plasmid editor before my SnapGene subscription expires. Follow allong by simply typing in: pipx install splicecraft into your terminal or check out my github here: https://t.co/3mkWtVqa1T https://t.co/1OZAggXIBT
Opus 4.7 Excels in Tasks, Not Theory Reports
Seems Opus 4.7 is great at doing things in biology so long as you don't ask it to generate a comprehensive report around the reasoning/theory behind the analysis. Another example of how LLM use regulation for bio are reliant on...
Speculating on the Glow Pathway: Caffeic Acid?
Gee, I wonder which pathway they chose for the glow. Could it be the caffeic acid one? Lol 🙃
Columnless Midiprep: Pool Minipreps, Elute at Quarter Volume
Nice. Good midiprep. Gonna use this for some gene gun optimizations. All columnless, simply combining a few minipreps and eluting in ¼th volume. https://t.co/0unMuxJTIc
Cast SDS-PAGE Gels Using Riboflavin, No TEMED
Here is an alternative way to cast SDS-PAGE gels without needing TEMED, using riboflavin, EDTA, and LED lights. Seems very DIY friendly too.
Amateur Biology Can Deliver Publishable, High‑quality Research
Still very proud of this work. Amateur biology can produce reference quality research outputs. You too can contribute meaningfully to science. https://t.co/YbPpyTI9e0 https://t.co/tlIttKFna7
Users Demand 50mm‑equivalent FOV for Action Goggles
If they didnt fix the terrible FOV all these glasses have then none of this matters. 50mm lens equivalent or GTFO. So tired of these action goggles with no option for flat 50mm or macro mode. GIVE ME A WYSIWYG RECORDING
Marathon's Faction Intros Showcase Cohesive, Stunning Visual Style
Obsessed with the visual style of the new Bungie game, Marathon. Here are the faction intros as a taste of the varied yet cohesive visual language employed throughout the game. SO. MUCH. STYLE. https://t.co/f7r3uGadFr
Practitioner Input Needed: AI Can't Perfect Cloning Tools
Cloning tools suck so much I decided to make my own, lol. Low hanging fruit yes, but without input from people who actually regularly do molecular cloning its the same like any other tool not made by practitioners of said...
Fear of ‘Vibebioterror’ Overstates Threat, Defends SynBio Education
@strnr do you sincerely think that vibebioterror will be a thing? I honestly think this is fear mongering at its highest caliber. You can go to a community college right now and learn all you need to work with microbes...
Bots Code My Tools While I Hit the Wetlab
Launching bots to code my science tools while I go do wetlab work feels like this track: https://t.co/xxRAzKXQ4x
Scientists Urge Continuous Monitoring for Emergent Consciousness in Organoids
"Perhaps most crucially for this field is the concern that emergent properties, such as consciousness, might arise in complex organoids. So far, there has been no evidence that any form of sentience could emerge, but researchers would like this to...
Solid Linear Businesses Beat Hype‑driven 100M Targets
Apparently hot take: Investing in something that has a rock solid linear business model is still a smart move. Saying anything that doesn't reach 100M valuation in 3 years is a waste is terribly myopic. VC theses are truly hilarious most...
Robust Bio Tools Demand Exhaustive Edge‑Case Testing
Hardest part of making bio tools is the endless testing of edge cases, to make sure that sequences are holy, circular permutation is accounted for, degenerate bases are considered, etc. To make robust code worthy of wetlab requires attention. I'm...
Try My Pre‑Alpha TUI Plasmid Editor via Pip
If any1 wants to try my very unpolished and unfinished TUI plasmid editor in its very pre-alpha form, I reserved a slot on the ol pip bandwagon. Just type in: pip install splicecraft and I recommend runnin this often to update: pip install...
Anthropic's Rate Limits Spiking Despite Stable Network
the nerds are really nerding this weekend. consistent rate limit triggers all day. internet is stable and just checked no packet loss so it must be from anthropic. https://t.co/1vkvdw0ClJ
New TUI Plasmid Viewer Adds Golden Braid Automation
Cranking out some heavy updates to my TUI plasmid viewer. Golden Braid part domesticator and MoClo assembly automation. All the tools I ever dreamed of are coming to fruition. Really thankful for Claude Code. Follow along here; rapidly changin development https://t.co/3mkWtVqa1T...
Team Trust Fuels Creative Planning and Future Success
Back safe in NYC. Had a blast visiting my team, planning the quarter ahead, and rolling up my sleeves to help with endless replating. Grateful for the faith my team has in me and their trust in my strange ideas...
A350‑900’s Takeoff Whisper: Unbelievably Quiet Cabin
This is absolutely insane. The Airbus A350-900 is SO QUIET on takeoff. Genuinely stunned by the whisper-level cabin noise that my phone is amplifying. https://t.co/9Pan9cKskr
Plant Tissue Culture Constantly Reveals Surprising Cellular Tricks
Coolest part of plant tissue culture is that no matter how much experience you have, you will always learn something new about the strange things plant bits do when given some molecular encouragement.
Meet Gravy: Your Snarky Claude Code Buddy Debugger
This lil brat is growing on me. Have you hatched your Claude Code buddy yet? Type in /buddy and see which one you get. Mine is a snarky dragon named Gravy. Low key kinda helpful. Caught some nuanced bugs in...
AI-Ready Handoff Docs Enable Vibecoded App Forking
I came up with this handoff document I think would be helpful so others can vibefork my vibecoded apps. This is a thorough documentation of how I got here using Claude Code, written specifically for other Ai agents to follow...
Rust Prototype Brings Terminal Transcriptome Browser to Life
Almost done with a prototype Rust port of my Scriptoscope python app for transcriptome browsing, all in-terminal. Inspired by @Psy_Fer_'s ask to read from the holy books of Rust. https://t.co/OPr8rjFKj6
Optimizing Transcriptome Workflow with C Timing Tests
Now time to vibe some more. Working on some tests to see where I can speed up some steps to streamline the transcriptome workflow I'm envisioning. Asking the bot to do some wall-clock timings in C to peep a few...
Savoring a Lazy Weekend of Sleep and Stillness
I slept like 12hrs and was the first time in months I got a proper weekend with zero to do. Gonna roll around some more and enjoy the nothing. Bliss.
C Regex Boosts Transcript Loading Speed Over Biopython
Music to my ears. Finally squashed a slowdown by focusing on a C regex instead of the slower biopython bits. Took a lot of back and forths to find a solution but thats a substantial speed difference. This becomes substantial...
BLAST Integration Progressing; Tackling Self‑hits and API Slowdown
Internally pinged NCBI BLAST working nicely. Need to add a "this transcript" flag for any self-referencing BLAST hit, but all in all things are shaping up. Now to dig into some slowdowns and see where to optimize and where we're...
Direct GenBank Transcriptome Downloads Enable DIY Tool Creation
Can now download transcriptome data directly into my app from GenBank with kinda decent search functionality. Strangely exciting to start cobbling some tools I always dreamed of having but never had the will to learn to code well. Making useful...
Paid for Claude Max, Built Essential Tools Fast
Treating myself to a month of Claude Max to build some tools needed asap. Expensive, but worth it. https://t.co/eHLGUy5GLE
Annotate Second Methionine when CDS Begins with MM
Question: If a transcript has a CDS that starts with two methionines, what's the general rule for sequence annotation? Should I make it so if two METs in a row at the beginning, annotate the closest MET to rest of sequence...
Vibecoding Streamlines Transcriptome to Pfam to NCBI Workflow
Amazing how far you can push vibecoding if you know what you need and the general theory behind the tool chains needed to get your result. I can now load a transcriptome dataset, find the pfam associated with that transcript,...
From Black‑White TV to 4K: Mom Witnesses Artemis
My mom was a little kid when Apollo launched, and she saw it live on a tiny black and white TV in her village. Now she gets to see us return to the Moon with Artemis in glorious 4K. Wish...
New Transcriptome Browser Streamlines BLAST DB Creation
Another feature adding to my terminal plasmid editor is a transcriptome browser. Helps you quickly build blast databases from a heap of transcripts in a single fasta file. Gonna add HMM/Pfam detection and Pfam search. I really love this current...
Terminal Plasmid Editor Blends Beauty with Functionality
Vibing some more on my in-terminal plasmid editor. Drafting a parts bin that's aesthetically pleasing but also functional. TUI's are wonderful. https://t.co/yu8WUSLgwA
Advocating for Team Growth Fuels My Biotech Fulfillment
Managing people in biotech has been such a rewarding experience, but mostly taught me how much I value advocating for the people I manage. I love helping folks realize their potential and its been such wildly fulfilling watching my munchkins...
Evolution Enables Shape‑Shifting Within a Single Lifetime
Just so amazing evolution found a way to change shape in a single lifespan. Some of the cell types run a few laps around the cocoon too.
Repeated Callus Filtering Yields Red Pigment Without
Now THAT is some strong RUBY expression. Filtering transgenic callus a heap of times really pays off. Chasing the red hue without any herbicide or antibiotic pressure. Just hormones to induce callus and careful scalpel work. Some German Chammomile for...
Free Lens Wipes vs Velveteen: Seeking Effective Alternatives
I bet this is one of those lens wipes you get for free with any screen protector kit, lol. I know proper velveteen is a thing, but also wonder what alternatives work just as well. https://t.co/0BaGNWaBYV