Spencer Nadolsky, DO
Obesity/lipid specialist physician; clear, evidence-based takes on nutrition, GLP-1s, supplements, and behavior change.
Naltrexone Boosts Weight Loss by Cutting Alcohol Intake
I have had a dozen or so patients who maxed out their weight loss on tirzepatide and then lost another 10-20 or more pounds after I added naltrexone. Why? After continued discussions they admitted they were still drinking a lot of alcohol. The tirzepatide, as good as it usually is, didn’t change their alcohol intake. The naltrexone did though and they were able to mostly eliminate alcohol and lose the weight (and get healthier).
Real Studies Show Sustainable Calorie Reduction Beats Extreme Diet Myths
Yeah so this didn’t happen. It may have felt like you were eating so few of calories but in rigorous study designs nothing like this actually happens. Yet I hear this type of thing often whether it’s with a GLP-1...
GLP‑1 and Testosterone Boosters Are Outright Scams
GLP-1 drops are a scam GLP-1 patches are a scam GLP-1 boosting supplements are a scam Also… Testosterone boosting supplements are a scam
GLP‑1 Drugs Boost Weight Loss and Health, Not Replace Lifestyle
Yes, GLP-1 meds help reduce your weight though a calorie deficit Yes, they have metabolic effects beyond this that help with various health conditions (CVD, psoriasis, alcohol abuse, etc). No, they don’t replace lifestyle changes. Yes, they help you make...
Start Lifting Now—Never Too Late, Even With GLP‑1
It’s not permanent. The best time to start lifting is before taking a GLP-1 medicine. The second best time is now. It’s never too late.
High‑dose Semaglutide Cuts Alcohol Use in RCT
Clinicians and patients saw big reductions in alcohol intake when starting GLP-1 medicine. This is the first randomized trial to look at the high dose of semaglutide. There was a study a couple years back looking at a lower dose....
Zepbound Sparks Diet Shift, Slashes LDL by One‑third
Patient started Zepbound and cut their LDL cholesterol essentially by a third and no longer in the range to start a cholesterol medicine. The medicine doesn't lower LDL cholesterol that much, but it did allow her to eat a more plant-forward...
Stopping Meds Causes Rebound, Not
You gain weight back after stopping a GLP-1 that means it’s bad. I guess my thyroid medicine is bad because if I stop it my thyroid levels will be nothing anymore and I’ll feel terrible.
Resistance Training Plus Protein: The Proven Muscle Formula
It’s simple yet we’ve known it for years. Resistance training + protein. No fear mongering needed. Comment “muscle” and I’ll send you the full podcast.
New GLP‑1 Pill Approved: Orfoglipron Offers Easier Dosing
New GLP-1 pill approved Foundayo (orfoglipron). Not as much weight loss as oral wegovy but no issues with food or more liquid around taking it. Same price. Not April fools joke.
Anti‑vaxxer Leads Healthcare: Real April Fool’s Situation
Who needs April Fools' when we have an anti-vaxxer running our healthcare and public health.
GLP‑1s Simplify Battling Uncontrolled Hunger
It’s not easy, but it’s simple. Nothing new here but this is how to do it. Some people’s dis regulated hunger makes this simple thing very hard to do. That’s where GLP1s come in. Keep at it ❤️
Misinformation Spreads Before April Fools, Targeting Vaccines, GLP‑1
It’s not even April fools yet and people are still making posts against vaccines and GLP-1 meds.
Split Zepbound/Mounjaro Doses Twice Weekly to Curb Hunger
Have hunger and food noise the last couple days before your Zepbound or Mounjaro shot? The half-life is 5 days for these which is why that might happen. Even with a higher dose this can happen. So I split their doses into...
Weight‑loss Drugs Curb Intake; Future Targets Calorie Burn
The current meds help people eat fewer calories. That’s how they work for weight loss (yes they have weight independent effects like CVD reduction). The next frontier is helping burn more calories.