New Study Says I Was Wrong About NMN and NR?
Recent human trials show that nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) raise blood NAD levels similarly, contradicting a small crossover study that claimed NR was superior. Both compounds appear to be metabolized largely by gut microbes into nicotinic acid before entering the Preiss‑Handler pathway. Larger meta‑analyses across older adults and long‑COVID patients find no consistent functional improvements despite NAD elevation. Consequently, the long‑standing NR‑vs‑NMN marketing battle may be overstated, while exercise remains a proven, low‑cost method to support NAD metabolism.
New Study Says I Was Wrong About NMN and NR?
The debate between nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) is losing relevance after recent trials. A crossover study of six adults showed NR raised blood NAD 2.3‑fold more than NMN, but a larger 65‑participant Nature Metabolism trial found both...
Lactoferrin: A Milk-Derived "Immunoceutical" Reverses the Clock on Inflammaging
Recent research highlights lactoferrin’s ability to modulate iron metabolism and reduce age‑related inflammation. A 2026 piglet study showed combined human milk oligosaccharides and lactoferrin enhanced lipid mobilization, antioxidant capacity, and neurodevelopment. A randomized trial in obese children reported three‑month lactoferrin...
AGI/ASI Timelines Thread (AGI/ASI May Solve Longevity if It Doesn't "Kill Us All" First)
OpenAI has dismantled several core safety groups, including the superalignment and AGI‑readiness teams, prompting resignations from senior researchers. The company’s latest Future of Life Institute report card awarded it an F for existential safety, matching most rivals except Anthropic and...
Lactoferrin: A Milk-Derived "Immunoceutical" Reverses the Clock on Inflammaging
Recent peer‑reviewed studies reveal that lactoferrin, especially when paired with human milk oligosaccharides, enhances lipid mobilization, antioxidant capacity and neurodevelopment in animal models, while a 2026 randomized trial shows it improves weight, liver enzymes and insulin resistance in obese children....
Lest We "Off" Ourselves (Cautionary Examples)
Investigative videos reveal that wellness influencers Mark Hyman and Jordan Peterson suffered severe sepsis after undergoing experimental stem‑cell and regenerative‑medicine procedures at Dr. Adil Khan’s unregulated clinics. The series links spinal injections and intravenous therapies to bacterial infections, highlighting the...
University of Arizona Launches $12 Million Rapamycin Clinical Trial
The University of Arizona’s R. Ken Coit College of Pharmacy is launching a double‑blind, randomized Phase 3 clinical trial to test low‑dose rapamycin’s ability to boost resilience and immune function in adults aged 65 and older. The six‑year study, funded by a $12 million...
University of Arizona Launches $12 Million Rapamycin Clinical Trial
University of Arizona’s R. Ken Coit College of Pharmacy is launching a double‑blind, randomized Phase 3 clinical trial to test low‑dose rapamycin’s ability to improve resilience and immune function in adults 65 and older. The $12 million study is fully funded by...
Dr. Kaeberlein's Optispan Podcast Series - Rapamycin and More
AI modeling compares 6 mg rapamycin taken with grapefruit juice versus berberine 1000 mg daily. Grapefruit juice irreversibly destroys intestinal CYP3A4 and P‑gp, boosting rapamycin AUC 3‑4× and Cmax 2.5‑3.5×, effectively tripling the dose for up to three days. Berberine provides reversible...
New Study Says I Was Wrong About NMN and NR?
A recent small crossover study suggested nicotinamide riboside (NR) raised blood NAD 2.3‑fold more than nicotinamide mononucleotide (NMN), but a larger Nature Metabolism trial with 65 participants found both precursors increased NAD similarly. Mechanistic work shows oral NR and NMN...
New Study Says I Was Wrong About NMN and NR?
Recent human trials have shown that nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) raise circulating NAD levels to a similar extent, contradicting a small Bergen study that suggested NR was superior. Both compounds appear to be metabolized largely by gut...
New Study Says I Was Wrong About NMN and NR?
Recent human trials have reignited the NR‑vs‑NMN debate, with a small six‑person crossover study suggesting NR raises blood NAD 2.3‑fold more than NMN, while a larger 65‑participant Nature Metabolism trial found no meaningful difference between the two. Both studies, however,...
Canagliflozin - Another Top Longevity Drug
Canagliflozin and other SGLT‑2 inhibitors are gaining attention as potential longevity agents due to their ability to cut cardiovascular events, renal decline, and COPD exacerbations in patients with type‑2 diabetes. Recent meta‑analyses show reduced emergency‑room visits and lower mortality among...
Life Expectancy in the USA and Around the World
The article highlights a surge in avoidable mortality as Europe ages, linking air pollution to cardiovascular risk and noting a sharp decline in the United Kingdom's healthy life expectancy to 61 years. In the United States, liberal states have achieved...