[Comment] Offline: President Trump—It Is Not Too Late
The Physicians for Human Rights report warns that recent U.S. cuts to global health funding under the Trump administration have crippled HIV/AIDS programs in South Africa, Kenya and other high‑burden countries. Primary‑care testing, PrEP distribution, antiretroviral therapy and research labs have been severely reduced or halted, leaving thousands without life‑saving services. The report argues that the funding gap threatens both public health outcomes and the return on decades of American investment in vaccine and drug development. It calls on Congress, multilateral agencies and non‑U.S. donors to restore support before the crisis deepens.
[Comment] Antibody-Based Malaria Prevention in an Intense Perennial Transmission Setting
A recent phase‑2 trial of the monoclonal antibody L9LS in Kenyan children demonstrated high efficacy against Plasmodium falciparum in an intense, year‑round transmission setting. The study reported roughly 70% protection after a single dose, with a safety profile comparable to...
[Comment] Treatment of Uncomplicated Lower Urinary Tract Infections in Women
Uncomplicated lower urinary tract infections affect roughly half of women at some point, making them a leading cause of outpatient antibiotic prescriptions. While single‑dose fosfomycin trometamol has been favored for convenience, recent randomized data—including the 2018 Huttner trial and the...
[Perspectives] On a Heating Planet, Do Humans and Corals Face a Shared Risk?
A new perspective piece highlights the intertwined fate of humans and coral reefs as global warming intensifies. Scientists now recognize that rising carbon dioxide levels disrupt the physiological processes of both corals and humans, beyond previously dismissed effects. The article...
[Perspectives] Refiloe Masekela: Building Access to Care for Childhood Lung Disease
Refiloe Masekela, a paediatric pulmonologist and dean at the University of KwaZulu‑Natal, reflects on South Africa’s early‑2000s HIV crisis that left many children dying from respiratory complications before antiretroviral therapy became widely available. She now spearheads initiatives to broaden access...
[Perspectives] Mammography Should Include Artificial Intelligence Support
The Mammography Screening with Artificial Intelligence (MASAI) randomised trial showed that a single radiologist assisted by an AI algorithm achieved higher sensitivity than the traditional double‑reading approach, while preserving specificity. Complementary studies from 2025‑2026 confirm AI’s scalability and equitable performance...
[Correspondence] Contemporary Non-Invasive Imaging for Coronary Artery Disease
The correspondence highlights three critical clarifications to a recent review on non‑invasive cardiac imaging. First, it stresses that patients with non‑obstructive coronary arteries can still experience angina and ischemia due to microvascular dysfunction or vasospasm. Second, it reinterprets the role...
[Perspectives] The Pitt: Essential Work
The Pitt, now in its second season, is a drama that follows a single, intense day in the emergency department of the fictional Pittsburgh Trauma Medical Hospital. Each episode captures one hour of that day, framing the narrative around chief...
[Obituary] John Bertrand Gurdon
Sir John Gurdon, a pioneering developmental biologist and 2012 Nobel laureate, died at 92. He proved that mature cells retain the full genetic blueprint by cloning a frog from an adult intestinal cell, overturning the belief that differentiation was irreversible....
[Comment] Liver Disease: Screening for the Elusive Adversary
The Lancet commentary revisits the classic Wilson‑Jungner criteria to evaluate whether population‑wide liver disease screening is justified. It highlights the disease’s long asymptomatic phase and dismal outcomes for late presenters, but points out the lack of consensus on diagnostic thresholds...
[Editorial] The Future of Preconception Health
The Lancet’s latest editorial revisits preconception health, highlighting that eight years after its 2018 series, research and policy still lag behind the broadened concept that includes both men and women. New reviews argue that men’s physical and mental health before...
[Comment] Casting First for Paediatric Wrist Fractures
Paediatric distal radius fractures are the most frequent wrist injuries in children, and their bones remodel well. Despite this, severely displaced fractures are often reduced under general anaesthesia and stabilized with wire fixation. Recent commentary highlights the paucity of high‑quality...
[Editorial] Childhood Cancer: Progress, but Not Enough
The CONCORD‑4 study shows that 68 countries have met or exceeded the WHO 60 % five‑year survival target for childhood cancer, with high‑income nations reaching 85‑90 % survival. However, 85 % of the 377,000 new cases in 2023 and 94 % of deaths occur...
[Comment] Childhood Cancer: An Equity Test for Global Health
A new Global Burden of Disease (GBD) analysis provides the first comprehensive estimates of childhood cancer incidence, mortality and DALYs from 1990 to 2023. The study highlights that only 21% of the world’s population lives in regions with population‑based cancer...
[Comment] 10 Years After NOBLE: More Nuance in Left Main Revascularisation
The recent 10‑year follow‑up of the NOBLE trial re‑examines revascularisation of unprotected left‑main coronary disease, finding no significant mortality difference between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). However, PCI continues to be associated with higher rates...