![[World Report] “We Don’t Want It to Happen to Others”: Suicide in Young Māori](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/84dff2305f673f64d60610ed84154a72.webp)
[World Report] “We Don’t Want It to Happen to Others”: Suicide in Young Māori
Suicide remains the leading cause of death for New Zealanders aged 15‑19, with Māori youth disproportionately affected. Recent research highlights a stark gap between Māori and non‑Māori suicide rates, underscoring systemic inequities. Advocates and community leaders are urging a shift toward culturally grounded prevention strategies, including greater use of marae‑based support networks. The call emphasizes urgent investment in mental‑health services tailored to Indigenous perspectives.
![[Comment] Could Enpatoran Add to Our Therapeutic Toolbox in SLE?](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/34fb3ece9b6e61491e68aaab9182a7fc.webp)
[Comment] Could Enpatoran Add to Our Therapeutic Toolbox in SLE?
Systemic lupus erythematosus (SLE) remains a heterogeneous disease with only two novel agents—BAFF and type‑1 interferon receptor inhibitors—approved since the 1950s. These drugs often fall short as stand‑alone treatments, are expensive, and are not uniformly accessible worldwide. Clinicians continue to...
![[Comment] Offline: Climate and Health—Time to Step up Our Activism](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/f3ce00c1c5aa7a835932084ee24ac680.webp)
[Comment] Offline: Climate and Health—Time to Step up Our Activism
A new study in Geophysical Research Letters finds that global warming has accelerated since 2015 with over 98% confidence, attributing the surge partly to reduced cooling aerosols from air‑pollution cuts. The 2026 Lancet Europe Countdown reports rising heat‑related mortality, longer...
![[Comment] RTS,S/AS01 Implementation Reduces Mortality in African Children](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/421f4ef62893dab4b11bed93097fa02e.webp)
[Comment] RTS,S/AS01 Implementation Reduces Mortality in African Children
A recent Lancet analysis shows that the RTS,S/AS01 (Mosquirix) malaria vaccine rollout in Ghana, Kenya and Malawi cut child mortality by roughly 20% after three years of implementation. The program reached over five million children under five, integrating the vaccine...
![[Comment] Colonoscopy, Cancer Prevention, and the New Arithmetic of Benefit](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/9c40ab18f39b6e9571bc1fd179f4f703.webp)
[Comment] Colonoscopy, Cancer Prevention, and the New Arithmetic of Benefit
Colonoscopy has long been hailed as the gold‑standard for colorectal cancer screening, with observational studies suggesting it cuts incidence and mortality by at least 50%. The 13‑year follow‑up of the NordICC randomised trial, however, shows a modest 18% reduction in...
![[World Report] Health on the Ballot in Senedd Cymru Election](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/7fa2f4db227895c130dd1e90d747299d.webp)
[World Report] Health on the Ballot in Senedd Cymru Election
The May 7, 2026 Senedd Cymru election places health at the forefront of the campaign as voters grapple with long NHS waiting lists, staffing shortages, social‑care gaps, and under‑funded services. All major parties have pledged to boost health spending and accelerate...
![[Comment] Offline: Ten Lessons for Women's and Children's Health](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/19845fe98e8f4fcd4ba5d32c8a649a42.webp)
[Comment] Offline: Ten Lessons for Women's and Children's Health
The Lancet commentary distills ten lessons from two decades of RMNCAH (reproductive, maternal, newborn, child, adolescent health) work, emphasizing that data‑driven accountability and cross‑sector partnerships sparked UN commitments and the Countdown tracking initiative. It warns that future progress must move...
![[Perspectives] Myopic Medical Harm: A Man Receives Free Colon Cancer Screening in Ghana](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/0b83d26c9666db4ba280a04bcb7f350b.webp)
[Perspectives] Myopic Medical Harm: A Man Receives Free Colon Cancer Screening in Ghana
A free colorectal‑cancer screening campaign in Ghana identified a positive fecal immunochemical test in Kwame, a 60‑year‑old farmer. The NGO’s program covered only the initial test, leaving Kwame to fund a confirmatory colonoscopy that costs roughly $750—about five times his...
![[Perspectives] Amita Aggarwal: Understanding Autoimmune Rheumatic Diseases](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/524d29ac2dcd72c9540d857b98e2497d.webp)
[Perspectives] Amita Aggarwal: Understanding Autoimmune Rheumatic Diseases
Amita Aggarwal, a clinical immunologist and rheumatologist, serves as Executive Director of AIIMS Bibinagar. Her childhood, marked by frequent relocations to Nepal, Iraq, and border regions during the 1971 India‑Pakistan war, gave her a unique cross‑cultural perspective. She emphasizes how migration,...
![[Comment] GLP-1 Therapies: An Emerging Approach for Alcohol Reduction?](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/f628ae5758874c46e9810dd10e2c007b.webp)
[Comment] GLP-1 Therapies: An Emerging Approach for Alcohol Reduction?
Alcohol use disorder (AUD) remains one of the world’s most prevalent yet undertreated conditions, with fewer than 2 % of affected Americans receiving an FDA‑approved medication. Recent randomized trials of once‑weekly GLP‑1 receptor agonists, especially semaglutide, have demonstrated statistically significant reductions...
![[Comment] HPV Vaccine Scale-Up Is Key to Curb Rising Cervical Cancer Inequalities](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/d5dae544601ad09d68c3dce84ec5011b.webp)
[Comment] HPV Vaccine Scale-Up Is Key to Curb Rising Cervical Cancer Inequalities
Despite advances in high‑income nations, cervical cancer deaths remain heavily concentrated in low‑ and lower‑middle‑income countries, where screening is scarce. Modeling studies show that scaling up HPV vaccination, especially with single‑dose regimens, could dramatically narrow these gaps. However, political and...
![[Comment] Evidence Into Action: Advancing Liver Health Policy in the WHO European Region](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/94b44132c7b95808f65a0514466db2d9.webp)
[Comment] Evidence Into Action: Advancing Liver Health Policy in the WHO European Region
The World Health Organization’s European office highlights the launch of the second EASL‑Lancet Commission on liver health, building on the 2021 report to drive policy action across the region. The commentary notes that liver diseases, including cirrhosis and liver cancer,...
![[Comment] Offline: President Trump—It Is Not Too Late](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/33edb6cd7db39a81ba27a2ec060c6b15.webp)
[Comment] Offline: President Trump—It Is Not Too Late
The Physicians for Human Rights report warns that recent U.S. cuts to global health funding under the Trump administration have crippled HIV/AIDS programs in South Africa, Kenya and other high‑burden countries. Primary‑care testing, PrEP distribution, antiretroviral therapy and research labs...
![[Comment] Antibody-Based Malaria Prevention in an Intense Perennial Transmission Setting](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/a3263fcd8d733301ef10712d19f5c34a.webp)
[Comment] Antibody-Based Malaria Prevention in an Intense Perennial Transmission Setting
A recent phase‑2 trial of the monoclonal antibody L9LS in Kenyan children demonstrated high efficacy against Plasmodium falciparum in an intense, year‑round transmission setting. The study reported roughly 70% protection after a single dose, with a safety profile comparable to...
![[Comment] Alzheimer's Disease Immunotherapy and the Amyloid Hypothesis: When Aggregation Obscures Interpretation](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/614bb5987569a37ee2c14e1338f7df10.webp)
[Comment] Alzheimer's Disease Immunotherapy and the Amyloid Hypothesis: When Aggregation Obscures Interpretation
A Cochrane review released on April 16, 2026 pooled data from 17 randomized trials of amyloid‑beta‑targeting monoclonal antibodies, encompassing more than 20,000 participants with mild cognitive impairment or mild dementia due to Alzheimer’s disease. The analysis found little to no...
![[Comment] Is Partial Complement Blockade Enough in Myasthenia Gravis?](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/efeb4e97504f7f1cdd947972b3a5f013.webp)
[Comment] Is Partial Complement Blockade Enough in Myasthenia Gravis?
The past eight years have seen a rapid expansion of targeted therapies for generalized myasthenia gravis, including complement C5 inhibitors, neonatal Fc receptor antagonists, and the anti‑CD19 B‑cell‑depleting antibody inebilizumab. Clinical trials have demonstrated meaningful reductions in disease activity, prompting...
![[Comment] Treatment of Uncomplicated Lower Urinary Tract Infections in Women](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/89a267f4f4bf9d67549ac574f13354b4.webp)
[Comment] Treatment of Uncomplicated Lower Urinary Tract Infections in Women
Uncomplicated lower urinary tract infections affect roughly half of women at some point, making them a leading cause of outpatient antibiotic prescriptions. While single‑dose fosfomycin trometamol has been favored for convenience, recent randomized data—including the 2018 Huttner trial and the...
![[Perspectives] On a Heating Planet, Do Humans and Corals Face a Shared Risk?](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/1febfda6fc816743cb59f037bcfbd96c.webp)
[Perspectives] On a Heating Planet, Do Humans and Corals Face a Shared Risk?
A new perspective piece highlights the intertwined fate of humans and coral reefs as global warming intensifies. Scientists now recognize that rising carbon dioxide levels disrupt the physiological processes of both corals and humans, beyond previously dismissed effects. The article...
![[Perspectives] Refiloe Masekela: Building Access to Care for Childhood Lung Disease](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/4d80850fccb4290715011ebe5c9ab6b6.webp)
[Perspectives] Refiloe Masekela: Building Access to Care for Childhood Lung Disease
Refiloe Masekela, a paediatric pulmonologist and dean at the University of KwaZulu‑Natal, reflects on South Africa’s early‑2000s HIV crisis that left many children dying from respiratory complications before antiretroviral therapy became widely available. She now spearheads initiatives to broaden access...
![[Perspectives] Mammography Should Include Artificial Intelligence Support](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/a8b50d033d7e546335a6ec09b92b1dc2.webp)
[Perspectives] Mammography Should Include Artificial Intelligence Support
The Mammography Screening with Artificial Intelligence (MASAI) randomised trial showed that a single radiologist assisted by an AI algorithm achieved higher sensitivity than the traditional double‑reading approach, while preserving specificity. Complementary studies from 2025‑2026 confirm AI’s scalability and equitable performance...
![[Correspondence] Contemporary Non-Invasive Imaging for Coronary Artery Disease](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/e5f5d89f21057c303d0efa1bf29145af.webp)
[Correspondence] Contemporary Non-Invasive Imaging for Coronary Artery Disease
The correspondence highlights three critical clarifications to a recent review on non‑invasive cardiac imaging. First, it stresses that patients with non‑obstructive coronary arteries can still experience angina and ischemia due to microvascular dysfunction or vasospasm. Second, it reinterprets the role...
![[Perspectives] The Pitt: Essential Work](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/4241c85d1998e320248886769c933277.webp)
[Perspectives] The Pitt: Essential Work
The Pitt, now in its second season, is a drama that follows a single, intense day in the emergency department of the fictional Pittsburgh Trauma Medical Hospital. Each episode captures one hour of that day, framing the narrative around chief...
![[Obituary] John Bertrand Gurdon](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/5811bed8c2fa1ae7323ccc02f30cf842.webp)
[Obituary] John Bertrand Gurdon
Sir John Gurdon, a pioneering developmental biologist and 2012 Nobel laureate, died at 92. He proved that mature cells retain the full genetic blueprint by cloning a frog from an adult intestinal cell, overturning the belief that differentiation was irreversible....
![[Comment] Liver Disease: Screening for the Elusive Adversary](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/78ddd2d9226c22494f867b221566624c.webp)
[Comment] Liver Disease: Screening for the Elusive Adversary
The Lancet commentary revisits the classic Wilson‑Jungner criteria to evaluate whether population‑wide liver disease screening is justified. It highlights the disease’s long asymptomatic phase and dismal outcomes for late presenters, but points out the lack of consensus on diagnostic thresholds...
![[Editorial] The Future of Preconception Health](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/d900c752411360a03295858b7f3d974d.webp)
[Editorial] The Future of Preconception Health
The Lancet’s latest editorial revisits preconception health, highlighting that eight years after its 2018 series, research and policy still lag behind the broadened concept that includes both men and women. New reviews argue that men’s physical and mental health before...
![[Comment] Casting First for Paediatric Wrist Fractures](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/385e9c59205388cc94f97787c4a24c8a.webp)
[Comment] Casting First for Paediatric Wrist Fractures
Paediatric distal radius fractures are the most frequent wrist injuries in children, and their bones remodel well. Despite this, severely displaced fractures are often reduced under general anaesthesia and stabilized with wire fixation. Recent commentary highlights the paucity of high‑quality...
![[Editorial] Childhood Cancer: Progress, but Not Enough](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/28aa7b79a0e44fd8c1effd8b006a4c38.webp)
[Editorial] Childhood Cancer: Progress, but Not Enough
The CONCORD‑4 study shows that 68 countries have met or exceeded the WHO 60 % five‑year survival target for childhood cancer, with high‑income nations reaching 85‑90 % survival. However, 85 % of the 377,000 new cases in 2023 and 94 % of deaths occur...
![[Comment] Childhood Cancer: An Equity Test for Global Health](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/5a4bd36d35a3297cb37f33621515df0d.webp)
[Comment] Childhood Cancer: An Equity Test for Global Health
A new Global Burden of Disease (GBD) analysis provides the first comprehensive estimates of childhood cancer incidence, mortality and DALYs from 1990 to 2023. The study highlights that only 21% of the world’s population lives in regions with population‑based cancer...
![[Comment] 10 Years After NOBLE: More Nuance in Left Main Revascularisation](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/51d0100d0ee81bbb3726be7a062c50fb.webp)
[Comment] 10 Years After NOBLE: More Nuance in Left Main Revascularisation
The recent 10‑year follow‑up of the NOBLE trial re‑examines revascularisation of unprotected left‑main coronary disease, finding no significant mortality difference between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). However, PCI continues to be associated with higher rates...
![[Obituary] Alan R Hinman](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/91c730229d2cdf07e809bf1e54e9b27e.webp)
[Obituary] Alan R Hinman
Alan R. Hinman, a pioneering epidemiologist and former CDC Assistant Surgeon General, died on Jan 26, 2026 at age 88. He led the CDC Immunization Division, tightening school vaccine mandates and slashing measles cases, and later directed the National Center for Prevention Services....
![[Perspectives] Face, Identity, and Culture](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/ba818a453d920e2c2cd8f52063a696e9.webp)
[Perspectives] Face, Identity, and Culture
Fay Bound‑Alberti, a modern‑history professor at King’s College London, discovered mid‑project that she suffers from prosopagnosia, a rare neurological condition also known as face blindness. The revelation came when she failed to recognize her own daughter among other toddlers at...
![[Comment] New Hope for Neurotrophin Targeting in Osteoarthritis Pain?](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/754aaf1faeb0d5f3b76618daddf79401.webp)
[Comment] New Hope for Neurotrophin Targeting in Osteoarthritis Pain?
Osteoarthritis (OA) remains a massive global health challenge with no disease‑modifying drugs and only modestly effective analgesics. The anti‑NGF monoclonal antibody, introduced in 2010, delivered unprecedented pain relief but was halted in 2021 after the FDA and EMA flagged joint...
![[Editorial] Politicisation of the US FDA: Eroding Integrity and Trust](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/2cbcac9eecf69b15e3915028747699be.webp)
[Editorial] Politicisation of the US FDA: Eroding Integrity and Trust
The editorial warns that increasing political interference is eroding the US Food and Drug Administration’s integrity and public trust. With a 2026 budget of $6.8 billion, the FDA remains the world’s most influential drug regulator, tasked with safeguarding safety while accelerating...
![[Comment] Monitoring Progress in Global Childhood Cancer Survival](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://www.thelancet.com/cms/asset/c8dfa205-a892-4c19-a13f-8bc6fec67e18/fx1.jpg)
[Comment] Monitoring Progress in Global Childhood Cancer Survival
Global childhood cancer survival remains starkly uneven, exceeding 80% in high‑income nations while hovering around 30% in low‑income regions. The Lancet highlights that 13.7 million children are projected to develop cancer between 2020 and 2050, with roughly 6.1 million likely to go...
![[Correspondence] Safeguarding Against Dengue Fever Risks in a More Connected World](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/0d754edb7784af3c8ea0cc186d55d361.webp)
[Correspondence] Safeguarding Against Dengue Fever Risks in a More Connected World
The Lancet correspondence highlights a series of low‑tech, community‑driven interventions that have demonstrably reduced dengue fever incidence in several low‑ and middle‑income countries. Partnering with ministries, transport operators and the GX Foundation, measures such as mosquito lamps, insecticide‑treated bednets and...
![[Correspondence] Closing the Adolescent Health Financing Gap: The Global Financing Facility](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/d96a88d7888b52d30a65025ec3a96c63.webp)
[Correspondence] Closing the Adolescent Health Financing Gap: The Global Financing Facility
Adolescent health remains one of the most under‑funded sectors in global development, despite adolescents (aged 10‑24) comprising roughly a quarter of the world’s population. Between 2016 and 2021, merely 2.4% of development assistance for health was allocated to this age...
![[Comment] Offline: Intelligence Does Not Prevent Stupidity](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/a955396a651d5f387e18780b4eb1a6bb.webp)
[Comment] Offline: Intelligence Does Not Prevent Stupidity
Giuliano da Empoli’s 2022 novel *The Wizard of the Kremlin* imagines a former Putin aide recounting the leader’s evolution from intelligence officer to autocrat. Through the fictional advisor Vadim Baranov, the book draws a stark contrast between a West driven...
![[Comment] Physiologically Guided CABG in Valve Surgery](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/3fd1de683d722a591ac21ac5870e845d.webp)
[Comment] Physiologically Guided CABG in Valve Surgery
Fractional flow reserve (FFR) provides a more precise physiological assessment of coronary lesions than angiography alone, and its wire‑based use has improved PCI outcomes. Angiography‑derived FFR extends this functional insight without pressure wires, showing strong correlation with invasive measurements. In...
![[Perspectives] Claire Calderwood: Integrated Health Screening for Tuberculosis](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/c234de0d49ef1ed6ce99bbd8a842690a.webp)
[Perspectives] Claire Calderwood: Integrated Health Screening for Tuberculosis
Claire Calderwood, an academic respiratory physician, argues for integrated health screening to combat tuberculosis. She highlights that respiratory disease prevention is intertwined with social and structural determinants of health. Calderwood’s work bridges clinical practice in the UK with research collaborations...
![[Comment] Should We Keep Pushing a High Fluid Intake in Kidney Stones?](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/71728300caabf9cdd7e72489bb93c7ec.webp)
[Comment] Should We Keep Pushing a High Fluid Intake in Kidney Stones?
High fluid intake remains the cornerstone for preventing kidney stones, yet patient adherence is consistently low. Systematic reviews and a recent 2026 randomized trial confirm that adequate hydration reduces stone recurrence, but practical, behavioral, and environmental barriers limit real‑world effectiveness....
![[Editorial] Making Treatment for Obesity More Equitable](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/9ad50868737552068254155c5d608c4d.webp)
[Editorial] Making Treatment for Obesity More Equitable
2026 could be a watershed year for obesity treatment as GLP‑1 receptor agonists cement their role after a decade of clinical success. The global market for weight‑loss drugs is forecast to hit US$150 billion by 2035, reflecting soaring demand. More than...
![[Obituary] Nicholas White](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/18e02f397e47fea422ba4d31bfe3f731.webp)
[Obituary] Nicholas White
Professor Sir Nicholas White, a pioneering pharmacologist and tropical‑medicine clinician, led the development and global adoption of artemisinin‑based combination therapies (ACTs) that transformed malaria treatment. His early trials in the 1990s demonstrated ACTs’ safety and efficacy, prompting a WHO guideline...
![[Correspondence] Health in Africa: The WHO African Region in the Next Decade](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/a9fe5635efddee78b24619bc1dc041d1.webp)
[Correspondence] Health in Africa: The WHO African Region in the Next Decade
In 2025 the WHO African region faced profound public‑health disruptions that accelerated a shift away from donor‑driven, disease‑specific programmes toward domestically financed, system‑wide strategies. Health is being repositioned as a macro‑economic asset, with preparedness, universal coverage and disease control framed...
![[Correspondence] National Lung Cancer Screening Programme in Brazil: An Urgent Need](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/4fbfeafc7f96396bcc6e234922df9c92.webp)
[Correspondence] National Lung Cancer Screening Programme in Brazil: An Urgent Need
Lung cancer caused 44,213 new cases and 38,292 deaths in Brazil in 2022, imposing heavy morbidity and costs on the public health system. Unlike many nations, Brazil lacks a national low‑dose CT (LDCT) screening programme, despite strong trial evidence that...
![[Perspectives] Hamlet and the Burden of Bereavement](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/5d4fc8859390c9589eb24113dec4659f.webp)
[Perspectives] Hamlet and the Burden of Bereavement
A new film adaptation of Shakespeare’s *Hamlet* directed by Aneil Karia re‑imagines the tragedy in suburban London’s South‑Asian milieu, casting Riz Ahmed as the brooding prince. The story replaces the Danish court with a ruthless capitalist property empire, using gritty cityscapes...
![[Perspectives] Lessons From the History of the Uganda Virus Research Institute](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/fa1fa72682f84e190ce5ce03ac058219.webp)
[Perspectives] Lessons From the History of the Uganda Virus Research Institute
During the 1960s, Uganda’s Virus Research Institute exemplified how African health research was rebuilt after independence, navigating the collapse of colonial institutions while maintaining productive collaborations. Today, abrupt reductions in U.S. development assistance—withdrawal from USAID, WHO, and Gavi—are destabilizing similar...
![[Comment] Moving Integrated Care Into the Community in Sub-Saharan Africa](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/753ebea3da7faa88e67cea3df67e4d36.webp)
[Comment] Moving Integrated Care Into the Community in Sub-Saharan Africa
Vertical HIV programmes in East and Southern Africa have successfully expanded rapid treatment access, but rising non‑communicable disease (NCD) comorbidities among people living with HIV now demand integrated service delivery. Recent pragmatic trials such as INTE‑AFRICA (2023) and INTE‑COMM (2026)...
![[Editorial] Back to Basics in Sickle Cell Disease](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/dfcc380d39fb22be7b9843b54e9e0246.webp)
[Editorial] Back to Basics in Sickle Cell Disease
Sickle cell disease affects roughly 8 million people worldwide, with deaths climbing 18.4% between 2000 and 2023. The burden falls hardest on sub‑Saharan Africa, where three‑quarters of infants are born with the condition and child mortality exceeds one in 20. Although...
![[Comment] Aldosterone Synthase Inhibition in Resistant Hypertension: Promises and Unknowns](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/0a5065acfb3787a2e2e6999bae6248e9.webp)
[Comment] Aldosterone Synthase Inhibition in Resistant Hypertension: Promises and Unknowns
Resistant hypertension affects up to 20 % of hypertensive patients and carries heightened cardiovascular risk. Recent phase‑3 studies of aldosterone synthase inhibitors such as baxdrostat and lorundrostat have demonstrated significant ambulatory blood‑pressure reductions, positioning them as potential fourth‑line agents beyond traditional...
![[Comment] Hypofractionated Nodal Radiotherapy in Breast Cancer: Time for an Updated Standard of Care?](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/51ee4beaf110fc3e1c92723294b3d34e.webp)
[Comment] Hypofractionated Nodal Radiotherapy in Breast Cancer: Time for an Updated Standard of Care?
The Lancet comment revisits hypofractionated nodal radiotherapy for breast cancer, highlighting its historical association with lymphoedema and brachial plexopathy due to high doses and poor protocol control. Early adoption of hypofractionation was driven by capacity constraints rather than trial evidence,...