![[Obituary] Alan R Hinman](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/91c730229d2cdf07e809bf1e54e9b27e.webp?width=1200&resize=contain&quality=75)
[Obituary] Alan R Hinman
Alan R. Hinman, a pioneering epidemiologist and former CDC Assistant Surgeon General, died on Jan 26, 2026 at age 88. He led the CDC Immunization Division, tightening school vaccine mandates and slashing measles cases, and later directed the National Center for Prevention Services. Hinman also served on Gavi’s board and advised the Task Force for Global Health, shaping vaccine equity worldwide. After retirement he mentored future public‑health leaders at Emory University, leaving a legacy of advocacy, editorial rigor, and optimism.
![[Perspectives] Face, Identity, and Culture](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/ba818a453d920e2c2cd8f52063a696e9.webp?width=1200&resize=contain&quality=75)
[Perspectives] Face, Identity, and Culture
Fay Bound‑Alberti, a modern‑history professor at King’s College London, discovered mid‑project that she suffers from prosopagnosia, a rare neurological condition also known as face blindness. The revelation came when she failed to recognize her own daughter among other toddlers at...
![[Comment] New Hope for Neurotrophin Targeting in Osteoarthritis Pain?](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/754aaf1faeb0d5f3b76618daddf79401.webp?width=1200&resize=contain&quality=75)
[Comment] New Hope for Neurotrophin Targeting in Osteoarthritis Pain?
Osteoarthritis (OA) remains a massive global health challenge with no disease‑modifying drugs and only modestly effective analgesics. The anti‑NGF monoclonal antibody, introduced in 2010, delivered unprecedented pain relief but was halted in 2021 after the FDA and EMA flagged joint...
![[Editorial] Politicisation of the US FDA: Eroding Integrity and Trust](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/2cbcac9eecf69b15e3915028747699be.webp?width=1200&resize=contain&quality=75)
[Editorial] Politicisation of the US FDA: Eroding Integrity and Trust
The editorial warns that increasing political interference is eroding the US Food and Drug Administration’s integrity and public trust. With a 2026 budget of $6.8 billion, the FDA remains the world’s most influential drug regulator, tasked with safeguarding safety while accelerating...
![[Comment] Monitoring Progress in Global Childhood Cancer Survival](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://www.thelancet.com/cms/asset/c8dfa205-a892-4c19-a13f-8bc6fec67e18/fx1.jpg)
[Comment] Monitoring Progress in Global Childhood Cancer Survival
Global childhood cancer survival remains starkly uneven, exceeding 80% in high‑income nations while hovering around 30% in low‑income regions. The Lancet highlights that 13.7 million children are projected to develop cancer between 2020 and 2050, with roughly 6.1 million likely to go...
![[Correspondence] Safeguarding Against Dengue Fever Risks in a More Connected World](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/0d754edb7784af3c8ea0cc186d55d361.webp?width=1200&resize=contain&quality=75)
[Correspondence] Safeguarding Against Dengue Fever Risks in a More Connected World
The Lancet correspondence highlights a series of low‑tech, community‑driven interventions that have demonstrably reduced dengue fever incidence in several low‑ and middle‑income countries. Partnering with ministries, transport operators and the GX Foundation, measures such as mosquito lamps, insecticide‑treated bednets and...
![[Correspondence] Closing the Adolescent Health Financing Gap: The Global Financing Facility](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/d96a88d7888b52d30a65025ec3a96c63.webp?width=1200&resize=contain&quality=75)
[Correspondence] Closing the Adolescent Health Financing Gap: The Global Financing Facility
Adolescent health remains one of the most under‑funded sectors in global development, despite adolescents (aged 10‑24) comprising roughly a quarter of the world’s population. Between 2016 and 2021, merely 2.4% of development assistance for health was allocated to this age...
![[Comment] Offline: Intelligence Does Not Prevent Stupidity](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/a955396a651d5f387e18780b4eb1a6bb.webp?width=1200&resize=contain&quality=75)
[Comment] Offline: Intelligence Does Not Prevent Stupidity
Giuliano da Empoli’s 2022 novel *The Wizard of the Kremlin* imagines a former Putin aide recounting the leader’s evolution from intelligence officer to autocrat. Through the fictional advisor Vadim Baranov, the book draws a stark contrast between a West driven...
![[Comment] Physiologically Guided CABG in Valve Surgery](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/3fd1de683d722a591ac21ac5870e845d.webp?width=1200&resize=contain&quality=75)
[Comment] Physiologically Guided CABG in Valve Surgery
Fractional flow reserve (FFR) provides a more precise physiological assessment of coronary lesions than angiography alone, and its wire‑based use has improved PCI outcomes. Angiography‑derived FFR extends this functional insight without pressure wires, showing strong correlation with invasive measurements. In...
![[Perspectives] Claire Calderwood: Integrated Health Screening for Tuberculosis](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/c234de0d49ef1ed6ce99bbd8a842690a.webp?width=1200&resize=contain&quality=75)
[Perspectives] Claire Calderwood: Integrated Health Screening for Tuberculosis
Claire Calderwood, an academic respiratory physician, argues for integrated health screening to combat tuberculosis. She highlights that respiratory disease prevention is intertwined with social and structural determinants of health. Calderwood’s work bridges clinical practice in the UK with research collaborations...
![[Comment] Should We Keep Pushing a High Fluid Intake in Kidney Stones?](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/71728300caabf9cdd7e72489bb93c7ec.webp?width=1200&resize=contain&quality=75)
[Comment] Should We Keep Pushing a High Fluid Intake in Kidney Stones?
High fluid intake remains the cornerstone for preventing kidney stones, yet patient adherence is consistently low. Systematic reviews and a recent 2026 randomized trial confirm that adequate hydration reduces stone recurrence, but practical, behavioral, and environmental barriers limit real‑world effectiveness....
![[Editorial] Making Treatment for Obesity More Equitable](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/9ad50868737552068254155c5d608c4d.webp?width=1200&resize=contain&quality=75)
[Editorial] Making Treatment for Obesity More Equitable
2026 could be a watershed year for obesity treatment as GLP‑1 receptor agonists cement their role after a decade of clinical success. The global market for weight‑loss drugs is forecast to hit US$150 billion by 2035, reflecting soaring demand. More than...
![[Obituary] Nicholas White](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/18e02f397e47fea422ba4d31bfe3f731.webp?width=1200&resize=contain&quality=75)
[Obituary] Nicholas White
Professor Sir Nicholas White, a pioneering pharmacologist and tropical‑medicine clinician, led the development and global adoption of artemisinin‑based combination therapies (ACTs) that transformed malaria treatment. His early trials in the 1990s demonstrated ACTs’ safety and efficacy, prompting a WHO guideline...
![[Correspondence] Health in Africa: The WHO African Region in the Next Decade](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/a9fe5635efddee78b24619bc1dc041d1.webp?width=1200&resize=contain&quality=75)
[Correspondence] Health in Africa: The WHO African Region in the Next Decade
In 2025 the WHO African region faced profound public‑health disruptions that accelerated a shift away from donor‑driven, disease‑specific programmes toward domestically financed, system‑wide strategies. Health is being repositioned as a macro‑economic asset, with preparedness, universal coverage and disease control framed...
![[Correspondence] National Lung Cancer Screening Programme in Brazil: An Urgent Need](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/4fbfeafc7f96396bcc6e234922df9c92.webp?width=1200&resize=contain&quality=75)
[Correspondence] National Lung Cancer Screening Programme in Brazil: An Urgent Need
Lung cancer caused 44,213 new cases and 38,292 deaths in Brazil in 2022, imposing heavy morbidity and costs on the public health system. Unlike many nations, Brazil lacks a national low‑dose CT (LDCT) screening programme, despite strong trial evidence that...
![[Perspectives] Hamlet and the Burden of Bereavement](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/5d4fc8859390c9589eb24113dec4659f.webp?width=1200&resize=contain&quality=75)
[Perspectives] Hamlet and the Burden of Bereavement
A new film adaptation of Shakespeare’s *Hamlet* directed by Aneil Karia re‑imagines the tragedy in suburban London’s South‑Asian milieu, casting Riz Ahmed as the brooding prince. The story replaces the Danish court with a ruthless capitalist property empire, using gritty cityscapes...
![[Perspectives] Lessons From the History of the Uganda Virus Research Institute](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/fa1fa72682f84e190ce5ce03ac058219.webp?width=1200&resize=contain&quality=75)
[Perspectives] Lessons From the History of the Uganda Virus Research Institute
During the 1960s, Uganda’s Virus Research Institute exemplified how African health research was rebuilt after independence, navigating the collapse of colonial institutions while maintaining productive collaborations. Today, abrupt reductions in U.S. development assistance—withdrawal from USAID, WHO, and Gavi—are destabilizing similar...
![[Comment] Moving Integrated Care Into the Community in Sub-Saharan Africa](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/753ebea3da7faa88e67cea3df67e4d36.webp?width=1200&resize=contain&quality=75)
[Comment] Moving Integrated Care Into the Community in Sub-Saharan Africa
Vertical HIV programmes in East and Southern Africa have successfully expanded rapid treatment access, but rising non‑communicable disease (NCD) comorbidities among people living with HIV now demand integrated service delivery. Recent pragmatic trials such as INTE‑AFRICA (2023) and INTE‑COMM (2026)...
![[Editorial] Back to Basics in Sickle Cell Disease](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/dfcc380d39fb22be7b9843b54e9e0246.webp?width=1200&resize=contain&quality=75)
[Editorial] Back to Basics in Sickle Cell Disease
Sickle cell disease affects roughly 8 million people worldwide, with deaths climbing 18.4% between 2000 and 2023. The burden falls hardest on sub‑Saharan Africa, where three‑quarters of infants are born with the condition and child mortality exceeds one in 20. Although...
![[Comment] Aldosterone Synthase Inhibition in Resistant Hypertension: Promises and Unknowns](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/0a5065acfb3787a2e2e6999bae6248e9.webp?width=1200&resize=contain&quality=75)
[Comment] Aldosterone Synthase Inhibition in Resistant Hypertension: Promises and Unknowns
Resistant hypertension affects up to 20 % of hypertensive patients and carries heightened cardiovascular risk. Recent phase‑3 studies of aldosterone synthase inhibitors such as baxdrostat and lorundrostat have demonstrated significant ambulatory blood‑pressure reductions, positioning them as potential fourth‑line agents beyond traditional...
![[Comment] Offline: The Silent Torment of Casey Means](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/d29724c6236ef051403e50259273b915.webp?width=1200&resize=contain&quality=75)
[Comment] Offline: The Silent Torment of Casey Means
Casey Means, a former ENT surgeon and author of *Good Energy*, was nominated by President Trump for U.S. Surgeon General and faced a Senate confirmation hearing dominated by vaccine questions rather than her metabolic‑health agenda. She argues that nine in...
![[Perspectives] Hadiza Shehu Galadanci: Strengthening Maternal Health in Nigeria](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/52b082cc64194e1f91a2de11b6fecc8d.webp?width=1200&resize=contain&quality=75)
[Perspectives] Hadiza Shehu Galadanci: Strengthening Maternal Health in Nigeria
Professor Hadiza Shehu Galadanci, director of the Africa Center of Excellence for Population Health and Policy, highlighted the urgent need to tackle postpartum haemorrhage (PPH) in Nigeria. She noted that while prevention and treatment methods exist, the majority of the...
![[Comment] Why Investing in Women's Health Is a Societal Imperative](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/e85a106906bfc6e377921705c114243b.webp?width=1200&resize=contain&quality=75)
[Comment] Why Investing in Women's Health Is a Societal Imperative
The commentary highlights that women experience nine additional years of poor health—25% more than men—primarily between menarche and menopause. Female‑specific conditions such as fibroids, endometriosis, and menopause‑related issues affect the majority of women, curtailing school attendance and workforce participation. Recent...
![[Comment] Hypofractionated Nodal Radiotherapy in Breast Cancer: Time for an Updated Standard of Care?](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/render/image/public/images/thumbnails/51ee4beaf110fc3e1c92723294b3d34e.webp?width=1200&resize=contain&quality=75)
[Comment] Hypofractionated Nodal Radiotherapy in Breast Cancer: Time for an Updated Standard of Care?
The Lancet comment revisits hypofractionated nodal radiotherapy for breast cancer, highlighting its historical association with lymphoedema and brachial plexopathy due to high doses and poor protocol control. Early adoption of hypofractionation was driven by capacity constraints rather than trial evidence,...