Dr. Lauren Colenzo-Sample: Why Everything You've Been Told About Training in Perimenopause Is Wrong

High Performance Health
High Performance HealthMar 30, 2026

Why It Matters

By rejecting dogmatic cycle‑syncing, women can adopt more flexible, evidence‑based training that enhances performance, reduces injury risk, and supports lifelong health, prompting fitness professionals to pivot toward personalized coaching models.

Key Takeaways

  • Avoid cookie‑cutter cycle‑syncing; personalize training to individual experience.
  • Hormonal phases show no consistent performance advantage for women.
  • Perimenopause symptoms, not hormones, should guide exercise adjustments.
  • Any rep range works if sets approach failure and progress.
  • Machines are as effective as free weights for beginners.

Summary

Dr. Lauren Colenzo‑Sample debunks the popular notion that women must align workouts with menstrual or perimenopausal hormone cycles. She argues that prescriptive, phase‑based programs are overly simplistic and can even undermine confidence, urging a shift toward individualized, autoregulatory training.

The evidence she cites shows wide variability in cycle length and symptom presentation, with no robust data supporting superior strength or recovery during the follicular or luteal phases. Likewise, perimenopausal hormone fluctuations do not dictate specific training rules; instead, symptoms like poor sleep or heightened stress should dictate temporary adjustments. Across ages, muscle hypertrophy is achieved when sets are taken close to failure, regardless of whether the load is heavy, moderate, or light.

Key quotes underscore her stance: “We should really stay away from any cookie‑cutter programs,” and “There is no scientific support for cycle‑phase specific training.” She also highlights that muscle quality is defined by strength relative to mass, not by intramuscular fat, and that machines can produce comparable gains to free weights for novices, easing intimidation in the gym.

For practitioners and women alike, the takeaway is clear: focus on consistent progressive overload, monitor holistic health markers (HRV, sleep, stress), and treat hormones as one factor among many. This approach simplifies programming, improves adherence, and supports long‑term health outcomes, reshaping how the fitness industry markets women‑focused training plans.

Original Description

You've been tracking your cycle, adjusting your workouts, and following the rules. Yet it still isn't working. Dr. Lauren Colenso-Semple, PhD in integrative physiology, breaks down what the science actually says about cycle syncing for women over 40 and the answer might surprise you.
Could everything you've been told about training around your cycle be completely wrong?
WHAT YOU’LL LEARN:
• Does cycle syncing actually improve workout results for women?
• Should you train harder in the follicular phase when estrogen is high?
• Do women in perimenopause need different training rules?
• Can you build muscle at any rep range or do you need to lift heavy?
• Is fasted training bad for women's hormones and adrenal health?
• Does caffeine before a fasted workout raise cortisol to dangerous levels?
• How much protein do perimenopausal women actually need per day?
• Is there a minimum protein threshold per meal for muscle building?
• Why is belly fat harder to lose after 40 and what actually works?
• Do you need zone two training for mitochondrial health in perimenopause?
• Can machine weights build as much muscle as free weights?
• What is the best exercise strategy for bone density in midlife women?
TIMESTAMPS
00:00 Cycle Syncing Myths: What Women Need to Know
02:41 Does Your Cycle Phase Actually Affect Performance?
07:54 Perimenopause Training: What Actually Needs to Change
09:08 Do Women Over 40 Need to Lift Heavier for Muscle Growth?
16:31 Machines vs. Free Weights: What's Best for Women?
19:16 HIIT vs. Zone 2 After 40: Which One Do You Actually Need?
26:48 Should You Train Fasted for Muscle Growth and Fat Loss?
36:34 Bone Density After 40: Best Exercises to Protect It
44:26 How Much Protein Do Perimenopausal Women Actually Need?
47:45 Belly Fat After 40: Why It Changes and How to Lose It
51:13 Exercise vs. Diet for Fat Loss: Which Moves the Needle?
54:13 Carbs After 40: Should You Fear Them?
56:47 The Empowering Truth About Exercise for Women Over 40
VALUABLE RESOURCES
• Take the BioSyncing Quiz to help you understand what’s actually happening in your body and how to fix it.
A BIG thank you to our sponsors who make the show possible:
• Stride - Find out your biological age and how your daily habits are influencing it with DNA, bloodwork and microbiome testing with a Stride One membership
ABOUT THE GUEST
Known for her evidence-based approach and myth-busting voice, Dr. Lauren Colenso-Semple is a trusted educator helping women cut through misinformation in female fitness and nutrition. She's a co-owner of the MASS Research Review and a sought-after speaker for podcasts, media, and educational platforms committed to science-backed health content.
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I’m Angela Foster - Nutritionist, Health & Performance Coach, and host of the High Performance Health podcast.
After leaving my career as a corporate lawyer due to burnout and illness, I rebuilt my physical, mental, and spiritual health through integrative science and lifestyle practices. Now, I help women in midlife feel 10 years younger by syncing with their biology, not fighting against it.
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