Today's Longevity Pulse
Retro Biosciences raises funds valuing it at $1.8 billion
Longevity startup Retro Biosciences announced a new fundraising round that values the company at $1.8 billion. The round is backed by OpenAI CEO Sam Altman. Retro aims to add ten healthy years to human life with gene and cell‑replacement therapies and is running its first clinical trial of a pill that enhances protein‑aggregate clearance in Alzheimer’s patients.
Global Report Flags Accountability Crisis for Longevity Clinics
A May 2026 report by the International Institute of Longevity and Longevity Think Tank finds 86% of surveyed clinics use biological‑age testing and all plan to expand, but warns the sector lacks validated outcomes. The findings signal a shift toward regulatory accountability and operational rigor for biohackers seeking clinic‑based interventions.
Your 20s Can Heal Pandemic Damage Through New Inputs
If you're in your 20s and you want to feel unstoppable, this is for you... Let's be honest. Your generation got screwed. More anxiety, more depression, less fertility, lower IQ than any generation before you. And most of it traces back...
Leukemia Drug HHT Delays Aging, Extends Mouse Lifespan
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice [an FDA-approved anti-leukemic drug; authors found that "HHT treatment delays aging and extends the lifespan in progeroid and aged mice"] https://t.co/LEegM8XUtR
GLP‑1 Gene Therapy: A One‑Time Fix for Obesity & Diabetes? | Longevity News Roundup — Week 21, 2026
The longevity roundup highlighted several breakthrough therapies, most notably Fractyl Health securing European approval for RJVA-001, a GLP‑1 gene therapy that programs pancreatic beta cells to secrete GLP‑1 after meals, potentially eliminating the need for chronic injections in obesity and...
The Aged Gut Microbiome Generates Extracellular Vesicles that Harm Tissue Function
Researchers identified that extracellular vesicles—specifically gut luminal exosomes (LFEs)—from aged mice carry proteins and microRNAs that impair intestinal barrier integrity and promote insulin resistance. Multi‑omic profiling revealed distinct age‑ and sex‑dependent cargo signatures, with old‑derived LFEs triggering metabolic dysfunction when...
USC Study Links Mediterranean Diet to Cellular Anti‑Aging Proteins
Researchers at USC's Leonard Davis School of Gerontology reported that older adults who closely follow a Mediterranean diet show higher levels of the mitochondrial microproteins humanin and SHMOOSE and lower oxidative‑stress markers. The pilot, involving 49 participants, offers a cellular...
Texas A&M Nasal Spray Reverses Brain Aging Markers in Mice
Texas A&M scientists unveiled a nasal spray packed with extracellular vesicles that, in mouse trials, erased neuroinflammation and restored mitochondrial function, leading to measurable cognitive gains. The two‑dose regimen produced effects within weeks that lasted months, positioning the therapy as...
STAT+: Longevity Startup Retro Biosciences Says Latest Fundraising Values It at $1.8 Billion
Longevity startup Retro Biosciences announced a new fundraising round that values the company at $1.8 billion. Backed by OpenAI CEO Sam Altman, Retro aims to add ten healthy years to human life using gene and cell‑replacement therapies. The firm is currently...
Structured Coaching Cuts Biological Aging by 0.014 in Large Trial
More than 2,100 older adults in the U.S. POINTER trial saw a 0.014 reduction in a composite frailty index after two years of coached exercise, diet and accountability. Researchers say the result provides the first large‑scale proof that lifestyle interventions...
New Study Shows Metformin Targets Gut, Shifting Anti‑Aging Narrative
Northwestern University scientists published a Nature Metabolism paper showing metformin primarily acts on intestinal cells to curb glucose absorption, overturning the long‑held view that its main effect is liver‑based. The finding could reshape how longevity enthusiasts dose the drug and...
Longevity Expert Dr. Charlop Joins FOX Business Roundtable
Dr. Gregory Charlop here. I’m excited to announce I’m a featured longevity expert on FOX Business. I’ll be appearing on the Barron’s Roundtable to discuss common-sense health solutions for executives and family offices.
Gut Health Is Becoming Programmable
The video outlines an emerging field where the gut microbiome can be programmed, moving beyond generic probiotic advice to precision interventions. Researchers now identify optimal microbial compositions for individuals and deliver them via personalized transplants, currently in early human trials. Companies...
This Stops Hair From Thinning, Graying, and Balding
The video argues that male-pattern thinning and graying are addressable without prescription drugs by targeting two distinct mechanisms: DHT signaling for thinning and oxidative/stem-cell damage for graying. It highlights pumpkin seed oil—rich in delta-7 sterols—as a dual-action food intervention that...
It Seems Like a Lot More People Are Getting This Message as They Get Older...
The video highlights an inflection point for middle‑aged adults who are now being told to prioritize bone density and muscle mass as they age. Experts cite a minimum protein intake of 0.7 g per pound of body weight and stress that many...
Podcast: What’s Taurine and Why Do We Care? (Part 2)
The podcast episode examines taurine, a conditionally non‑essential amino acid, its age‑related decline, and whether supplementation can extend human healthspan. Animal work shows that restoring taurine in mice, worms and monkeys reverses age‑related decline and lengthens lifespan. Human meta‑analyses (2020, 2024)...
TPE Long-Term Effects in Healthy Elderly Same as Sham
A 2025 Aging Cell trial of therapeutic plasma exchange (TPE) with and without IVIG in 42 healthy adults over 50 showed a modest 2.6‑year biological‑age reduction at the mid‑point but no significant difference versus sham at the final assessment. The...
Review Finds Glycine‑NAC Combo May Boost Mitochondria and Muscle Health
A recent scientific review concludes that combining the amino acids glycine and N‑acetylcysteine (NAC) shows promise for supporting mitochondrial efficiency and muscle health. The analysis, which spans laboratory, animal and early human trials, highlights potential benefits for people with low...
SIRT6 Boost Reverses Age-Related Liver Chromatin Decline in Mice
Scientists at Bar‑Ilan University reported that elevating the protein SIRT6 in old mice restores youthful liver chromatin architecture and suppresses inflammatory gene activity. The intervention protected roughly 95% of age‑linked chromatin changes, suggesting a gene‑level route to anti‑aging therapies.
Best Longevity Retreats & Destinations (2026): An Independent, No-BS Guide
The longevity‑retreat market has exploded, offering programs from $340‑night fasting centers to $5,000‑night elite diagnostic experiences. Evidence‑based options—especially medically supervised fasting and the Pritikin program—show measurable health improvements, while many luxury integrative retreats rely on amenities over outcomes. International venues...
KHL Foundation Launches a Medical Tourism Gene Therapy Program for Older Patients
The KHL Foundation, founded by longevity veterans Ken Scott and Helga Sands, has launched a medical‑tourism program that offers a gene‑therapy cocktail to people over 60. The Rejuvenation Cocktail combines intramuscular follistatin with intranasal klotho and SIRT1, targeting muscle, brain...