Today's Longevity Pulse
Updated 2h ago
Loyal Secures $100M to Develop Canine Longevity Drugs Targeting IGF‑1 and PPAR Pathways
Loyal, a veterinary biotech firm, announced a $100M financing round to advance its platform for extending the lifespan of senior and large‑breed dogs. The company focuses on the IGF‑1 and PPAR pathways and has obtained conditional efficacy approvals from the FDA’s Center for Veterinary Medicine for two therapeutics.
Loss of Smell May Signal Alzheimer’s Years Before Cognitive Decline, Study Finds
Scientists have identified a decline in olfactory ability as a possible early warning sign of Alzheimer’s disease, driven by microglial attacks on smell‑related nerve fibers. The finding could reshape screening strategies and intersect with meditation‑based approaches to brain health.
One Drink Harms Health: Quit Alcohol Now
Friends, stop drinking alcohol. Not cut back. Eliminate. > alcohol increases cortisol > disrupts REM sleep > accelerates epigenetic aging > shrinks hippocampal volume > elevates resting heart rate > raises inflammatory markers > impairs glucose metabolism for 16 hrs One drink does that.
Live 3-Day Water Fast Kickoff with Josh Duhamel
Josh Duhamel and I are about to start our live call to our community of >5000 who registered for our quarterly 3 day water fast for health at 11 a PT. Join our community here: https://fastforhealth.co/ Or just watch the live feed...
Osteoporosis Exercise Scientist: The Lifting Protocol That Reduces Fractures by 78% Dr Belinda Beck
The video features Dr. Belinda Beck, a bone‑densitometry expert, who challenges the long‑standing belief that osteoporosis patients cannot safely engage in heavy resistance exercise. She explains that mechanical loading, proven in animal studies, triggers a dose‑response in bone tissue, and...
Heart Metrics Reveal Youthful Physiology and Peak Fitness
Left chart: my resting heart rate = 46 on Apr 12 60, top 5% A.I. says - High parasympathetic activity Efficient cardiac output Exceptionally strong pairing Your physiology seems “younger” than your chronological age
Prioritize Hormones Before Peptides for Optimal Balance
Peptides are everywhere right now but most people miss the order of operations: hormones first, peptides second. For a range of supplements that can help balance your hormones, as well as numerous beneficial peptides, Biolongevity Labs has it all. USA-manufactured, third-party...
She Was Told MS Was Irreversible… Then She Walked Again
The Longevity Technology Unlocked podcast featured Dr. Terry Walls, a neurologist‑researcher who transformed her own secondary progressive multiple sclerosis (MS) from wheelchair‑bound to walking and biking by combining a rigorously designed paleo diet, targeted supplements, electrical muscle stimulation and strength...
Calorie Cutting Lowers Epigenetic Age and Inflammaging Protein C3a
Caloric restriction (CR) slows aging in rodents. People who cut calories by 14% over 2 years had lower epigenetic ages of some tissues & inflammatory protein C3a, regardless of BMI. In mice, lowering C3a levels reduced inflammaging, especially in fat....
You're Not Tired. Your Mitochondria Are. The Estrogen Connection in Perimenopause No One Explains
The video explains how declining estrogen during perimenopause triggers a cascade of mitochondrial dysfunction, leaving many women feeling a sudden loss of energy compared with men’s gradual decline. It frames mitochondria as cellular power plants whose efficiency depends on hormonal...
You Have 5 Years Left." She Proved Them Wrong - Twice! With Leslie Kenny
The episode of "Better with Dr. Stephanie" centers on spermidine, a naturally occurring polyamine, and its capacity to counteract the twelve hallmarks of aging. Host Dr. Stephanie Estima interviews Leslie Kenny, who survived multiple autoimmune diagnoses and a five‑year mortality...
Loyal Raises $100 Million: Dog Longevity Drugs Targeting IGF-1 and PPAR Pathways
Loyal, a veterinary biotech firm, announced a $100 million financing round to advance its canine longevity platform. The company targets the IGF‑1 and PPAR pathways to develop drugs that extend the lifespan of senior and large‑breed dogs. It has secured conditional...
Magnetic Fields From Earphones and Mobile Phones 'Suck' Airborne Magnetic Particles Into the Brain, Impairing Cognition and Potentially Contributing to...
A Chinese Academy of Sciences team published in ACS Nano that static magnetic fields from everyday earphones and smartphones dramatically increase brain accumulation of airborne magnetite nanoparticles in mice. The combined exposure amplified nanoparticle uptake by roughly five times and caused...
341. Taking Type II Collagen Over Other Forms - Life Extension
In this episode, Dr. Mike and Dr. Crystal Gossard interview Dr. Daniel Martinez‑Puch, head of R&D at BioAberica, to explain the differences between hydrolyzed (denatured) collagen and native (undenatured) type II collagen. Dr. Martinez‑Puch describes how native type II retains its triple‑helical...
Why Fast-Cycling Skin Cells Decrease With Age
Researchers published in Aging Cell that the extracellular matrix protein fibulin‑5 supports fast‑cycling epidermal stem cells, which are essential for skin renewal. Mice lacking fibulin‑5 displayed premature skin thinning, reduced fast‑cycling cell zones, and altered expression of adhesion, replication, and...
There’s a Link Between Heart Health and Hip Fracture
A new study published in The Lancet Regional Health – Americas links cardiovascular risk to a markedly higher chance of hip and other major bone fractures in postmenopausal women. Using the American Heart Association's PREVENT score, researchers found women in...
Sarcopenia -- New Clues
Recent preclinical and clinical work links low‑grade inflammation to age‑related muscle loss, or sarcopenia, and shows that ibuprofen can blunt this process. In 20‑month‑old rats, a five‑month ibuprofen regimen cut inflammatory markers by up to 60% and boosted post‑prandial muscle...
The Cellular Incinerator: How Interventions Like Rapamycin Hijack Autophagy to Hack Aging
A recent review by Ebata and Hansen (2026) synthesizes evidence that dietary restriction, intermittent fasting, spermidine‑rich foods, exercise, sleep hygiene, and hormetic temperature stress all stimulate autophagy—a cellular recycling process linked to longer healthspan. In model organisms, these interventions require...
Advanced Meditation Techniques Linked to Younger Brain Age During Sleep
Researchers measured sleep EEGs of 34 long‑term meditators and found their brains appeared biologically about six years younger than their chronological age. The younger brain age was driven by high‑amplitude bursts during light sleep, despite the meditators sleeping fewer hours...
APLMS and Kitalys to Host Healthy Longevity in Hong Kong
The Asia‑Pacific Longevity Medicine Society and the Kitalys Institute will host the 2026 Asia‑Pacific Healthy Longevity International Summit in Hong Kong from October 1‑4, 2026. The four‑day event expects more than 2,000 leaders from longevity medicine, geroscience, pharma, digital health, AI...
