Know What's Happening in Longevity
Know What's Happening in Longevity
Longevity Pulse
EMAIL DIGESTS
Daily
Every morning
Weekly
Tuesday recap
EMAIL DIGESTS
Daily
Every morning
Weekly
Tuesday recap
University of Arizona launches $12M rapamycin trial for seniors
The R. Ken Coit College of Pharmacy is starting a double‑blind, randomized Phase 3 study to test low‑dose rapamycin’s ability to improve resilience and immune function in adults aged 65 and older. The six‑year trial, funded by a $12 million philanthropic gift from alumnus Ken Coit, will randomize participants to rapamycin or placebo for two years before long‑term follow‑up.
Aging clocks, built on DNA‑methylation patterns, aim to quantify biological age as a shortcut for long‑term health outcomes. Researchers view them as surrogate endpoints that could compress 20‑year anti‑aging trials into months, helping evaluate drugs or lifestyle interventions. However, the market now offers consumer‑focused tests while scientific validation of clinical utility remains limited. Recent comparative studies pit epigenetic clocks against traditional actuarial mortality models to assess whether they truly outperform existing risk calculators.
What if one small nerve quietly connects your brain to your heart, your gut, your immune system — and even how long you live? That was the question I brought to Dr. Elisabetta Burchi, a clinical psychiatrist, neuroscience researcher, and Head...
As a medical school professor, I teach that sleep matters for metabolism. But now we have the precise number. A study of 23,475 adults published in BMJ Open Diabetes Research & Care found the optimal sleep duration for preventing insulin resistance:...
The UK Medicines and Healthcare products Regulatory Agency (MHRA) has launched an investigation into several peptide clinics that are promoting unregulated, experimental peptide injections as medicinal treatments. Clinics are advertising products such as BPC‑157, Cortexin and Thymosin Alpha with claims...
As a medical school professor, I never imagined a single mineral could be this important to gut health. But the data is staggering. A new study in Aging Cell found that magnesium levels decline specifically in the gut as we age...
Dr. Daniel Promislow has spent 30+ years studying the biology of aging and has published 180+ papers. Now he’s applying that science to something millions of people care about personally: Why do dogs age the way they do, and can we help...
Peptides—short chains of amino acids—are gaining popularity for weight loss, anti‑aging, and injury recovery. While prescription drugs like semaglutide and tirzepatide are FDA‑approved, most products marketed online are experimental, unregulated compounds such as BPC‑157, TB‑500, and CJC‑1295. Scientific reviews show...
New paper @GladstoneInst @UCBerkeley @nvidia reinforces the Information Theory of Aging (ITOA). Looking at 175M single-cell gene expression patterns, AI found cells lose their identity over time. The model then predicted how to restore lost information to rejuvenate cells…🧵 https://t.co/oU3fYiqRzd
You will see many posts from me on the concept of Peakspan and Peakspan Extension. Here is what Peakspan is and why it is important. It is important for our economy and for our life. #Peakspan https://t.co/yGL6zMr4Rh
Recent research identifies neuronal HDAC9 as a pivotal regulator of synaptic health and cognition during aging. The study shows that HDAC9 expression declines in the cortex of Alzheimer’s disease (AD) patients and aged mice, correlating with synaptic loss and memory...
In terms of slowing the age-related loss of fitness, I'd bet the same is true for those who standardize their workouts, when compared with those who "switch it up"
If you prioritize one thing to completely change your life, focus on your sleep. For less than $200, you can block junk light and repair your circadian rhythm. Studies show that even a small amount of streetlight pollution at night...
The article outlines 13 vitamins essential for optimal brain function and explains how deficiencies can blunt the effects of popular nootropic supplements like racetams and tryptophan. It cites NHANES data showing over 40% of U.S. adults lack adequate vitamin intake,...
As a medical school professor, I need to be honest: there is no safe level of alcohol for your brain. A landmark study of 36,000 brain scans found that even one drink per day shrinks your brain -- and the damage...
As a medical school professor, I used to tell patients to "eat healthy fats." But the type of olive oil matters more than we ever taught. A new study in Microbiome (Feb 2026) tracked 650 adults for 2 years and found...
A new open‑access review highlights the cGAS‑STING pathway as a central driver of ovarian aging, linking DNA and mitochondrial leaks to chronic inflammation and follicle loss. The authors propose three therapeutic angles: small‑molecule inhibitors that silence cGAS or STING, upstream...
Women are not “mini-men.” That line from Dr. Jennifer Pearlman MD CCFP NCMP FAARM ABAARM stuck with me from our @Optispan_Inc Podcast conversation—and it sets the stage for a much bigger issue. For decades, medicine and biomedical research have often treated...
DNA repair-driven epigenetic changes as a cause of disease is going mainstream. A general medical review on CVD says: Genomic instability & epigenetic reprogramming are the deep mechanisms of vascular aging. Intervention strategies are the most promising & complex interventions https://t.co/xbEytAnIUH
A new molecular psychiatry study of 672 community‑dwelling older Asian adults found that higher depressive symptom severity is associated with accelerated epigenetic aging, especially measured by the second‑generation PC‑PhenoEAA clock (β = 0.087 per standard‑deviation increase; clinical depression raises PC‑PhenoEAA by 0.24 SD)....
Impressive temporal AI model of aging by @GladstoneInst Based on ~175M single-cell transcriptomes, the model predicts drivers of cell trajectories across human aging. Also great that the first author, Javier, trained in our lab. Always rewarding to see our alumni flourish.
New research confirms: optimal hormone levels don't just make you feel better, they help you live longer. Everything you need to support your hormones in one place. Biolongevity Labs, where all supplements and compounds are USA-made, third-party tested, with 99% purity....
Researchers applied a machine‑learning model to sleep‑EEG recordings from more than 7,000 participants, generating a “brain age” index that reflects how fast the brain appears to age. The analysis showed that a brain age ten years older than a person’s...
At Lifespan, we care about you, your loved ones, and humanity. A special project is to record and safeguard human knowledge and biological information, so civilization and our biology can be restored if lost. @joinlifespan, and let's achieve longevity for...
LDL is only part of the equation. What's your Lp(a), VLDL, ApoB? Risk-weighted ApoB, which incorporates all of the above, is a better measure than LDL for predicting CVD risk: https://t.co/y5Hc9ZXIWG
Researchers identified the orphan nuclear receptor NR0B2 (also known as SHP) as a protective factor in cartilage, with its expression markedly reduced in osteoarthritic tissue. In male mice, global or chondrocyte‑specific deletion of Nr0b2 worsened pain and joint damage after...
Some doctors say wearables & epigenetic age tests aren’t useful because they aren’t clinically approved But a new study of 178 people over a year says otherwise When people saw their data & biological age, they changed behavior & saw measurable improvements...
If longevity escape velocity arrives by 2033 (Ray K’s prediction), a 50-year-old today has a shot at seeing 2100. The prize: 50 extra healthy years of compounding knowledge, relationships, and impact. Worth optimizing for? Focus on a longevity mindset.
The peptide revolution will require a small (reservoir enabled) auto syringe that doses at intervals with multiple peptides throughout the day. Basically a parallel exo-somatic signaling system.
This kind of post infuriates my science colleagues & fuels trolls We’ve published that we have reversed the epigenetic age of nerve cells. That’s true! Reversing the age of entire mice is not When claims get exaggerated like this, how’s anyone...
Anyone who thinks that Longevity Biotechnology is new and in the next 10 years we will find a cure for aging with AI should read Paul Segall's "Living Longer, Growing Younger". 1989. Read "Merchants of Immortality" 2003 next. I think that the...
Highest anthocyanin-containing foods: 1. Black elderberry: 1,317 mg per 100 g 2. Black chokeberry (aronia): 878 mg per 100 g 3. Blackcurrant: 592 mg per 100 g 4. Black raspberry: 589 mg per 100 g 5. Black rice: 325 mg per 100 g 6. Bilberry: 299...
Life is a marshmallow test. Incretin modulators help you win while staying happy. I often ask big audiences - "how many of you are on GLP1?" and only a couple hands go up. Sometimes, none. That's when I understood that...
Age is not fixed. It’s dynamic. This is one of the most remarkable discoveries of the century
Kudos to Peter - and to David for highlighting it to 8x more people than I am doing here :-) But yes, without actual life-extension progress in a mammal, the Overton window seems immoveable. My TED talk was 20 years...
This is a thoughtful essay on a new preprint from Raghav Sehgal and Albert Higgins-Chen that’s worth your time. It highlights something we don’t talk about enough: for biological aging clocks to be useful outside of research, they need to...
As a medical school professor, I never learned this in training: the plastic in your food may be fueling cancer. A new Journal of Clinical Investigation review (Feb 2026) maps how micro/nanoplastics drive cancer through 4 mechanisms: 1. Inflammation: Macrophages engulf plastic...
Most people treat aging as fate.�Biology treats it as a process that can be changed
Negative relationships may accelerate biological aging. In a new study, each additional “hassler” - someone who often causes problems or makes life difficult - was linked to ~1.5% faster aging and ~9 extra months of biological age. The catch: this showed up...
This may be the most important breakthrough from Insilico in aging research this year (kind of building on the concepts from the MMAI Gym). Turns out, you do not need original biological data to train foundation models to predict...
Woah. I'm slightly embarrassed that I missed this for a few weeks. Finally there is approval, in a Large Nation, for a stem cell-based REPLACEMENT therapy for an age-related condition. The condition is, no surprise, Parkinson's, which I always highlight...
As a medical school professor, I tell students exercise is medicine. But a new study shows the TYPE of exercise determines whether your brain grows new neurons. Researchers compared treadmill running vs. coordination exercises at matched intensity. Published in Frontiers in Neuroscience: ->...
Is aging programmable? It implies there IS a program created by evolution, not only accident or entropy. But that's a debate. Here's a paper by business consultant Michael Ringel, on this very topic, with many good citations. https://t.co/fREM4AHnJG
"Peakspan" should be the longevity marker everyone's talking about. It refers to how long we can maintain 90% or more of our peak capacity in one of several health domains like muscle strength, cognitive function, or fertility. And it recognizes that these...
Muscle loss doesn’t just gradually decline with age. A lot of it may happen in ‘catabolic crises’ - sharp drops after periods of disuse like injury, bed rest, hospitalization, or stopping training. The real harm is not just aging itself,...
As a medical school professor, I teach that autophagy -- the body's cellular recycling system -- is one of the most powerful defenses against aging and disease. Now the first-ever human clinical trial proves a fasting mimicking diet activates it. Cedars-Sinai and...
As a medical school professor, I teach students that Alzheimer's has many risk factors. But this one is invisible -- and almost nobody talks about it. A massive study of 27.8 million Medicare beneficiaries just found that fine particle air pollution...
Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication https://t.co/DT8GXNLlxO
What if your doctor handed you a report… and it was no more meaningful than a horoscope? That’s the uncomfortable reality we’re facing right now in longevity medicine. When clinicians use unvalidated, non-actionable tests, they are replacing evidence-based medicine with something that...
