Today's Longevity Pulse
Retro Biosciences valued at $1.8B after latest fundraising round
Longevity startup Retro Biosciences announced a new fundraising round that places its valuation at $1.8 billion. The round is backed by OpenAI CEO Sam Altman and supports the company’s goal to add ten healthy years to human life through gene and cell‑replacement therapies. Retro is also launching its first clinical trial of a pill designed to clear protein aggregates in Alzheimer’s patients.
MMA.INC (NYSE American: MMA) Enters Exclusive 50/50 Revenue Share Peptide Partnership with Precision Peptide (CSE: BPC)
Mixed Martial Arts Group Limited (MMA.INC) announced an exclusive partnership with The Precision Peptide Company, granting MMA.INC a 50/50 share of net revenue from peptide sales sourced through its combat‑sports ecosystem for the first year, then 25% thereafter. The agreement gives MMA.INC direct marketing rights to U.S.-manufactured, third‑party tested peptide recovery products across platforms such as TrainAlta, BJJLink and its global network of gyms. The deal requires no capital outlay, creating a high‑margin vertical aligned with the rapidly expanding recovery, longevity and performance‑optimization market. Both parties can terminate with 30‑day notice, with a 12‑month tail for revenue sharing after exit.
7 Years, 700 Mg/dL Cholesterol, Zero Coronary Plaque
🚨New Paper: "Seven Years of 700 Cholesterol Without Coronary Atherosclerosis" After 7 years of ~700 mg/dl cholesterol, 0 mm3 total plaque (soft +calcified) after expert analysis and AI-guided quantification. Open-access paper linked below.
Olive Oil and Coffee Linked to Slower Cellular Ageing in Spanish Study
Researchers from the University of Navarra presented data showing that regular intake of olive oil and coffee correlates with slower telomere shortening in middle‑aged Spaniards. The findings, unveiled at the European Congress on Obesity in Istanbul, add new evidence that...
Scientists Question $1,000‑Plus NAD+ Supplements Amid Booming Longevity Market
Leading researchers say the surge in NAD+ supplements and infusions outpaces the scientific evidence supporting them. While clinics charge hundreds to thousands of dollars per treatment, human trials remain small and inconclusive, fueling a debate between biohackers and the scientific...
These 10 Nutrients Are A Must For Healthy Aging — Are You Getting Enough?
A new nationwide analysis reveals that most Americans, even those who consider their diets "healthy," fall short on ten key nutrients linked to healthy aging. The study found 21 of 24 examined micronutrients were under‑consumed, with Vitamin D, Vitamin E, calcium, magnesium...
What Brazilian Supercentenarians Can Teach Us About Living To 110
Brazilian researchers examined over 100 centenarians, including 20 supercentenarians, uncovering three biological advantages—robust protein maintenance, resilient immune function, and rare protective gene variants. These elders often live without advanced medical care, highlighting lifestyle and genetic factors that sustain health into...
Why Consistency Beats Perfection When It Comes To Healthy Aging
A May 2026 JAMA Network Open study of 207 adults, average age 68, linked stronger, more regular circadian rhythms to slower epigenetic age acceleration measured by GrimAge and PhenoAge. Participants wore wrist devices for a week, allowing researchers to map rest‑activity...
This Common Breakfast Food May Reduce Your Risk of Alzheimer’s
Researchers at Loma Linda University tracked nearly 40,000 adults for over 15 years and found that regular egg consumption is associated with a lower risk of Alzheimer’s disease. Eating at least one egg five days a week reduced the risk...
Digital Aging Twin Links Liver Coagulation to Systemic Aging
A new computational framework, the Digital Aging Twin, quantifies how different organs age at varying rates and identifies liver-derived coagulation factors as direct drivers of systemic aging, offering a precise tool for personalized aging assessment. agingbiology
Evening Workouts Enhance Diabetes Control, Reduce Inflammation
Timing matters 🕒 For type 2 diabetes, afternoon/evening exercise boosts insulin sensitivity & glycemic control, while morning workouts may raise blood sugar. Later workouts are also linked to lower cortisol, less inflammation & better oxidative capacity. #Diabetes #ExerciseScience @WuTsaiAlliance https://t.co/5Bc0PUAE9O
Digital Aging Twin Measures How Organs Age at Different Speeds Across Adulthood
Researchers from China’s Aging Biomarker Consortium unveiled the Digital Aging Twin, a computational framework that predicts biological age and organ‑specific aging rates using 240 physiological and multi‑omics measures from 2,019 healthy adults. The system features a three‑tier clock architecture, with...
Tomatidine Boosts Memory and Cuts Cellular Aging in Mice
Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice https://t.co/jVfshXgzxQ https://t.co/6l86CBdoBC
Science Journalism's Optimism Skews Longevity Coverage
Appreciate the gift link from Eric. Disagree on conclusion though - if you accept that science journalism is always optimistic, this was solid coverage of longevity by @susandominus. Should have mentioned @newlimit though, and named Cynthia Kenyon.
Urolithin A Trial Shows 12% Muscle Strength Gain and Better Endurance in Middle‑Aged Adults
Researchers at EPFL and the NIH reported that a clinical trial of Urolithin A supplementation increased muscle strength by 12% and enhanced aerobic endurance in middle‑aged participants. The results highlight the compound’s potential as a mitochondrial‑targeted anti‑aging supplement, while underscoring the...
Organ Age Asynchrony Predicts Mortality Risk
From ageing clocks to organ networks: Biological age-driven organ asynchrony and inter-organ interactions shaping mortality risk https://t.co/y02SJj7q2q https://t.co/ObuzzNQczW
Engaging with the Arts Linked to Slower Aging at the Biological Level
University College London researchers found that regular engagement in arts—reading, music, museum visits—correlates with a slower biological aging pace. Analyzing data from 3,556 UK adults using seven epigenetic clocks, participants who engaged in arts at least weekly aged about 4%...
Arts and Cultural Engagement ‘Linked to Slower Pace of Biological Ageing’
University College London researchers have found that regular engagement with the arts—whether creating music or visual art, or simply visiting galleries and museums—slows the biological aging process. The study, which examined epigenetic markers in a large UK cohort, showed that...
New AI Target Discovery Paper Sets Benchmark
New Paper Alert 🚨: A collaboration with the leading target ID experts in Nature Reviews Drug Discovery. If you are looking to teach your AI target discovery - this is a good place to start. Thanks Peter Kirkpatrick for giving...
Measure Biology, Not Trends, to Extend Longevity
Most people are trying to optimize their health without ever measuring what actually matters. The reality is: aging is a biological process you can track (and in many cases, influence) when you know what to look for. Longevity isn’t built on trends....
Study Links Five Eggs a Week to 27% Lower Alzheimer’s Risk
Researchers from Loma Linda University analyzed data from the Adventist Health Study‑2 and found that adults who ate five or more eggs per week had a 27% lower risk of being diagnosed with Alzheimer’s disease. The finding, published in The...
Eli Lilly’s Orforglipron Cuts Weight up to 13% and HbA1c 1.7% in Seniors, Study Shows
At the European Congress on Obesity, Eli Lilly presented a post‑hoc analysis of its oral GLP‑1 agonist orforglipron showing seniors lost up to 13% of body weight and cut HbA1c by 1.7% over 72 weeks. The findings, drawn from 616 participants...
Is Longevity a $1.2 Quadrillion Opportunity?
Peter Diamandis released the 2026 Longevity Metatrend Report, a free 200‑page analysis of the rapidly advancing health‑span sector. The report highlights breakthroughs such as human trials of partial epigenetic reprogramming, AI‑engineered proteins achieving 50‑fold efficacy gains, and the first pig‑organ...
Walking and Strength Training Are Must-Do Workouts for Longevity. Here’s How to Build Your Routine.
The piece underscores that walking and strength training are complementary pillars for longevity. Walking delivers low‑impact cardiovascular, brain and bone benefits, while strength training excels at preserving muscle mass, bone density and metabolic health. Experts from Strong with Sarah, ACSM‑EP...
Centenarian Doctor and William Shatner Reveal Simple Rules for Longevity
Howard Tucker, the Guinness‑World‑Record‑holding 103‑year‑old neurologist, and actor William Shatner, 95, each disclosed three straightforward habits that have helped them stay sharp, happy and active. Their advice ranges from keeping the mind exercised to befriending pain and moderating pleasure, offering...
Inactivity Imprints Molecular Memory in Muscle, Aging Amplifies Damage
A study in Advanced Science reveals that periods of disuse leave a lasting molecular memory in skeletal muscle. Young adults develop a protective transcriptional response, while aged muscle shows amplified atrophy and mitochondrial dysfunction, a finding that could reshape biohacking...
An Ancient Hibernation Switch Lives in Your DNA—And Scientists Are Tapping Into Its Power
Scientists have identified ancient cis‑regulatory DNA switches that enable hibernating mammals to shut down and restart metabolism safely, and they found the same genetic circuitry embedded in the human genome. The finding comes from two new studies published in Science...
Fasting-Mimicking Diet Clinical Trial Led to 2.5 Years of Reduced Biological Aging, 12.5 Years Increase I Max Life Expectancy if...
A recent clinical trial of a fasting‑mimicking diet (FMD) reported a 2.5‑year reduction in biological age and, if sustained for two decades, a projected 12.5‑year increase in maximum life expectancy. Participants in online forums describe lower hsCRP, improved heart‑rate variability,...
How the Collapse of Nitric Oxide Signaling Accelerates Aging
A recent audit of commercial fermented beetroot powders uncovers major standardization gaps in fermentation methods, nitrate and betalain quantification, and drying processes. The analysis ranks five popular brands by cost per 100 mg of powder, showing Better Health as the cheapest...
Dietary Advanced Glycation End Products as Active Drivers of Biological Aging
Advanced glycation end products (AGEs) formed during high‑heat, dry cooking are now recognized as active drivers of biological aging rather than passive biomarkers. Dietary AGEs (dAGEs) cross‑link proteins and activate the RAGE‑NF‑κB axis, promoting oxidative stress, vascular stiffening, impaired bone...
More Sunshine = More Longevity?
Large epidemiological studies in the UK and Sweden link higher sunlight exposure to a 12‑15% drop in overall mortality and roughly a 50% reduction in death risk for sun‑seeking individuals. The Economist cites mechanisms beyond vitamin D, including UV‑triggered nitric oxide...
Discussing Drugs to Slow Ageing BSRA Youtube Video
The British Society for Research on Ageing hosted a public discussion with Professor Gordon Lithgow, highlighting that ageing is a modifiable biological process demonstrated in model organisms such as C. elegans. Lithgow emphasized the exposome’s potential to accelerate ageing, the...
Naked Mole‑Rat Gene Extends Mouse Lifespan by 4.4%, Marking First Cross‑Species Longevity Transfer
Researchers at the University of Rochester have engineered mice to carry the naked mole‑rat version of the hyaluronan synthase 2 gene, raising high‑molecular‑weight hyaluronic acid levels and delivering a 4.4% increase in median lifespan. The study demonstrates that a longevity...
Cardiovascular Health 2026
Recent imaging studies reveal that subclinical atherosclerosis is common well before symptoms appear. The PESA study shows 63% of asymptomatic adults aged 40‑54 have plaque in at least one vascular bed, while the SCAPIS trial reports 42% of 50‑64 year‑olds...
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These Everyday Habits From Blue Zones Could Help You Live Longer, Say Longevity Experts
Longevity experts highlight that residents of the world’s five blue zones—Okinawa, Sardinia, Nicoya, Ikaria and Loma Linda—share a handful of everyday habits that extend both lifespan and healthspan. Core practices include predominantly plant‑based meals, daily low‑intensity movement, strong social ties,...
Duke Study Shows Six Blood piRNAs Predict Two‑Year Longevity with 86% Accuracy
Researchers at Duke Health announced a blood test that measures six circulating piRNAs and predicts two‑year survival in adults over 71 with up to 86% accuracy. The finding, published in Aging Cell, could give clinicians and biohackers a precise, minimally...
Evidence for Sleep Apnea to Accelerate Vascular Aging via Increased Cellular Senescence
Researchers modeled obstructive sleep apnea by exposing C57BL/6J mice to intermittent hypoxia. The exposure rapidly increased epigenetic age acceleration and p16‑positive senescent cells in vascular tissue. Mice developed higher systolic and diastolic pressure and endothelial dysfunction. Systemic removal of p16‑expressing...
Microgravity as a Model of Aging
Researchers used simulated microgravity in a rotating‑wall vessel bioreactor to expose peripheral blood mononuclear cells from participants in the Stanford 1,000 Immunomes Project. Whole‑genome transcriptomic and metabolic profiling showed that microgravity‑induced changes closely track natural aging trajectories across immune, metabolic,...
Lifelong Cognitive Enrichment Is Linked to a 38 Percent Lower Risk of Alzheimer’s Disease
A study of 1,939 older adults in the Rush Memory and Aging Project found that higher lifetime cognitive enrichment reduces Alzheimer’s disease risk by 38% per point increase. Participants with the highest enrichment scores developed dementia about five years later...
GrimAge Predicts Mortality in Centenarians Beyond Immune Aging
Advances in precision geriatrics. GrimAge methylation clock works in centenarians. Striking new preprint from the Henne Holstege lab (Yaran Zhang et al., 100-plus Study) in n=247 cognitively healthy Dutch centenarians: GrimAge predicts mortality at extreme old age (HR ≈ 1.6...
Longevity Experts Prioritize Quality Over Length of Life
Main Line Area Experts Take a Fresh Approach to Aging Longevity experts are emphasizing quality of life as the focus shifts from “longer" to “better." @MainLineToday https://t.co/TWv1M9wPMj https://t.co/m3ZzIQHH2O
NAD Supplements Often Mislabelled, Quality Varies Widely
Independent testing of NAD supplements like NR & NMN suggests there's considerable variability in the quality and what's on the label doesn't necessarily match what's in the product https://t.co/Q7TlAZE5f8
One‑point Mediterranean Diet Boost Cuts Mortality by 4%
Adherence to the Mediterranean diet and all-cause mortality: A systematic review and meta-analysis within the Italian National Guidelines “La Dieta Mediterranea” "Each 1-point MD score increase reduced mortality risk by about 4%." https://t.co/l1VEnyEb29 https://t.co/RU5hAnNG1n
Phone‑Free Forest Bathing Cuts Resting Heart Rate
48 hrs forest bathing this weekend. No phone. Resting heart rate lowered 10%. It was glorious. Have you done that recently?
Take Control of Your Lifespan With Simple Steps
How long do you want to live? There's something you can do about it... https://t.co/uDdQlcNn65
Healthspan over Endless Life: Avoid Tithonus’s Cursed Immortality
People are complaining about doctors promoting "healthspan" at the expense of extreme life extension. The myth of Tithonus is relevant here. Made immortal by a goddess, she forgets to give him everlasting youth. He ends up shut into a room unable...
Low‑dose Cialis May Protect Brain Vascular Health, Curb Dementia
ED drugs like Cialis & Viagra, when taken as a low dose daily, can help maintain vascular function in brain and muscle, and are a promising, though still debated, approach for preventing & treating dementias. The human data for Cialis...
Exercise‑induced Exosomes Deliver NAMPT, Boost NAD, Protect Liver
Interesting new paper: In old mice, exercise releases bubble-like blood vesicles called "exosomes" carrying NAMPT, the enzyme that makes NMN Evidence indicates NAMPT's ability to raise NAD and activate liver SIRT1 may be why exercise counteracts fatty liver and fibrosis 🏃♀️🏃♂️...
Vascular Dysfunction May Drive Cognitive Decline and Dementia
Emerging research links vascular dysfunction to cognitive decline in aging & dementia. Reduced blood flow and blood-brain barrier breakdown may play a key role—and could even be causally connected. Understanding this opens the door to new, much-needed therapies. #Neuroscience #Aging...
Decoding Epigenetic Clocks: Pathways Behind Accelerated Aging
How epigenetic clocks tick: Unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging https://t.co/MU3R25TEu3