Know What's Happening in Longevity
Know What's Happening in Longevity
Longevity Pulse
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Every morning
Weekly
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Arizona launches $12M rapamycin trial to boost immunity in seniors
The University of Arizona’s R. Ken Coit College of Pharmacy is starting a double‑blind, randomized Phase 3 trial testing low‑dose rapamycin’s effect on resilience and immune function in adults aged 65 and older. The six‑year study, funded by a $12 million philanthropic gift from alumnus Ken Coit, will randomize participants to rapamycin or placebo for two years before a two‑year follow‑up.
A new molecular psychiatry study of 672 community‑dwelling older Asian adults found that higher depressive symptom severity is associated with accelerated epigenetic aging, especially measured by the second‑generation PC‑PhenoEAA clock (β = 0.087 per standard‑deviation increase; clinical depression raises PC‑PhenoEAA by 0.24 SD). Anxiety scores showed no reliable link to any of the six epigenetic clocks examined. Longitudinal analyses over a median 4.8‑year follow‑up revealed that within‑person increases in depression tracked concurrent rises in PC‑PhenoEAA. The findings highlight a biological aging pathway specific to late‑life depression in an Asian cohort.
As a medical school professor, I tell students exercise is medicine. But a new study shows the TYPE of exercise determines whether your brain grows new neurons. Researchers compared treadmill running vs. coordination exercises at matched intensity. Published in Frontiers in Neuroscience: ->...
"Peakspan" should be the longevity marker everyone's talking about. It refers to how long we can maintain 90% or more of our peak capacity in one of several health domains like muscle strength, cognitive function, or fertility. And it recognizes that these...
Researchers applied a machine‑learning model to sleep‑EEG recordings from more than 7,000 participants, generating a “brain age” index that reflects how fast the brain appears to age. The analysis showed that a brain age ten years older than a person’s...
Muscle loss doesn’t just gradually decline with age. A lot of it may happen in ‘catabolic crises’ - sharp drops after periods of disuse like injury, bed rest, hospitalization, or stopping training. The real harm is not just aging itself,...
As a medical school professor, I teach that autophagy -- the body's cellular recycling system -- is one of the most powerful defenses against aging and disease. Now the first-ever human clinical trial proves a fasting mimicking diet activates it. Cedars-Sinai and...
Researchers identified the orphan nuclear receptor NR0B2 (also known as SHP) as a protective factor in cartilage, with its expression markedly reduced in osteoarthritic tissue. In male mice, global or chondrocyte‑specific deletion of Nr0b2 worsened pain and joint damage after...
As a medical school professor, I teach students that Alzheimer's has many risk factors. But this one is invisible -- and almost nobody talks about it. A massive study of 27.8 million Medicare beneficiaries just found that fine particle air pollution...
Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication https://t.co/DT8GXNLlxO
A new Science Weekly podcast examines the growing trend of alternating sauna sessions and cold‑plunge immersions, dissecting the scientific evidence behind claimed health benefits. Researchers discuss modest cardiovascular gains linked to regular sauna use and short‑term muscle recovery from cold‑water...
What if your doctor handed you a report… and it was no more meaningful than a horoscope? That’s the uncomfortable reality we’re facing right now in longevity medicine. When clinicians use unvalidated, non-actionable tests, they are replacing evidence-based medicine with something that...
enjoying this piece on record life expectancy increasing over time - the *insane* linear regression in 1840 - 2010 period just tracking record life expectancy over time (I think trend not consistent since, partic w COVID) - how funny it is that...
Recent animal research shows that high-dose nanoplastic accumulation can trigger cellular dysfunction, including oxidative stress and senescence. While these harmful exposure levels exceed current environmental concentrations, older adults may experience greater cumulative burden due to lifelong exposure and age‑related physiological...
Facial aging is not a surface-level process. It reflects progressive changes in bone structure, fat compartments, collagen architecture, UV exposure, and hormonal signaling over time. The important point is that many of these pathways are modifiable. Daily photoprotection, resistance training, adequate...
Dehydration can shrink your brain by over 0.5%, and may be a reason you get a headache. Hydrate to maintain light yellow urine. Also hydrate before an MRI, as dehydration-related small decreases in brain volume can confound MRI-based assessment...
Garage Brain Science (GBS), a Taiwan biotech, announced new clinical collaborations to develop rapid, at‑home screening tools for early metabolic stress linked to prediabetes and structural abnormalities of the TDP‑43 protein associated with neurodegenerative diseases. The company is leveraging blood‑based...
This study on visceral fat loss blew my mind... It found that sustained visceral fat reduction over years was linked to preserved brain volume and cognitive function in middle age. They tracked people for up to 16 years, and those who lost...
Astaxanthin is a major antioxidant that's 100x more potent than vitamin E and vitamin C - protects skin against UV damage - lowers inflammation and neuroinflammation - lowers lipids and blood pressure - protects against oxidation of fats - protects the eyes - senolytic properties - lowers...
Partial reprogramming—brief exposure to Yamanaka factors OCT4, SOX2, KLF4 and MYC—has demonstrated modest rejuvenation in mouse studies but carries a substantial cancer risk if cells slip into full pluripotency. Funding is concentrated in a few well‑capitalized firms, notably Altos Labs,...
As a medical school professor, I've seen textbooks call it "metabolically healthy obesity." A new study proves that label is dangerously misleading. Karolinska Institute tracked 7,275 children with obesity until age 30. The results in JAMA Pediatrics are staggering: -> 9% of "metabolically...
When 'Normal Labs' Are Unhealthy We sit down with Dr Sandeep Palakodeti —an Ivy League–trained internist who left elite institutions—to unpack why so much of healthcare reacts to disease instead of building durable health, and how treating your body like your...
Dave Asprey’s monthly "Dave’s Favorite Products" series spotlights biohacking tools that reinforce four core health pillars—circulation, cellular strength, mitochondrial energy, and nervous‑system resilience. The February 2026 post continues the trend, linking to January and December roundups that curate supplements, wearables,...
As a medical school professor, I've recommended metformin to countless patients. But a new double-blind trial just revealed something alarming. Metformin BLUNTED the insulin-sensitizing benefits of exercise in adults at risk for metabolic syndrome. The findings from a 16-week RCT: -> Exercise +...
Lp(a) is the new Voldemort of cardiology—a genetically determined risk factor that can raise your risk of heart disease by >200%. And while elevated Lp(a) is largely written into your DNA, there’s good news: You may be able to neutralize its...
Dave Asprey and PUORI CEO Oliver Amdrup‑Chamby reveal widespread contamination in the supplement market, showing that plant‑based and organic protein powders can contain up to ten times more heavy metals than whey. They explain that the organic label offers no...
A mutation in the IVNS1ABP gene causes a new disease combining premature aging and severe neurological decline by disrupting cell scaffolding, leading to DNA damage and “zombie-like” senescent cells. https://t.co/xtDrjy72h4
🤣 That’s why we make sure the reprogramming technologies we develop can’t take cells back in epigenetic age more than ~75%
Recent studies from the Cleveland Clinic and the University of Colorado Boulder have identified erythritol, a widely used sugar‑alcohol, as a potent risk factor for cardiovascular disease. Elevated blood erythritol levels were associated with roughly a two‑fold increase in heart...
Longevity 2.0: Your next doctor won't prescribe pills—they'll prescribe gene therapies, epigenetic reprogramming, and personalized longevity protocols. Medicine is shifting from "treat symptoms" to "reverse aging at the cellular level."
One reason I dislike saying healthspan or lifespan & prefer aging as label for the field over longevity. Aging puts focus on its terrible consequences/pathology. It makes the field defensive like medicine not greedy as some see wanting more life...
Tai chi, a slow‑movement exercise that blends posture, breath control, and meditation, is emerging as a leading preventive tool for older adults. Recent clinical trials and meta‑analyses show it markedly improves balance, proprioception, and lower‑limb strength, which reduces both fall...
Paragon launched its 7th company today -- Korsana Biosciences, merging into the $CYCN public shell. New ticker will be $KRSA. Lead drug candidate is a shuttled anti-amyloid beta antibody for Alzheimer's disease in early studies. https://t.co/RcJ8adMakm
The longevity factor spermidine is part of a highly heritable complex erythrocyte phenotype associated with longevity https://t.co/rHT8XoWHFz
Dave Asprey visited Costa Rica’s RMI Clinic to undergo a neurocognitive protocol that blends functional MRI mapping, neuronavigation, transcranial magnetic stimulation, focused ultrasound and mesenchymal stem‑cell infusion. The treatment targets hypofunctioning brain regions with millimeter precision and is followed by...
social disconnection is not just painful emotionally, it puts the body under biological stress. It is linked to higher inflammation, worse cardiovascular health, and a higher risk of early death, while stronger social relationships are consistently associated with better survival....
Sleep loss can causally drive heart disease. 1/2) Here's how it works: Sleep loss causes release of a brain hormone (hypocretin) --> goes to bone marrow to simulate the production of inflammatory cells --> these go to arteries and drive atherosclerosis But...
The Live Foreverish episode hosted by Dr. Mike and Dr. Crystal tackles chronic fatigue syndrome, highlighting how nutrient‑based strategies can alleviate persistent exhaustion. They discuss established supplements such as CoQ10, B‑complex vitamins, and vitamin C, explaining their roles in cellular...
Norn Group has released a free, detailed spreadsheet that maps 47 age‑related disease indications, providing mechanisms, incidence, market size, clinical endpoints, animal models, and trial cost estimates. The guide is designed to help longevity‑focused startups choose FDA‑approved disease targets rather...
