Marrying Into Long-Lived Families Boosts Spouse Health Beyond Genetics
Familial healthy aging and longevity: the role of spouses "Spouses marrying into longevity-enriched families exhibit a substantial and broad health advantage that is not attributable to shared genetic predisposition to longevity or socioeconomic differences." https://t.co/UzWkyMq7Kq
Metformin Shows No Impact on Epigenetic Aging in HIV Patients
Metformin and epigenetic age in non-diabetic older people with HIV in Madrid (METFORAGING): a double-blind, randomised, placebo-controlled, pilot trial "...no significant difference was noted in the primary outcome between groups..." https://t.co/gfrIJIq1f8
Steve Austad Forecasts Field’s Future Pride and Regret
I asked Steve Austad what one thing the field will be proud of 10 years from now, and one thing we may be embarrassed about. Full interview here: https://t.co/npZ3cbCw66 https://t.co/8jaZ3wbtZj
Loss of Resilience Drives Age‑related Disease Risk
An 80-year-old has a dramatically higher risk of cancer, heart disease, stroke, and dementia than a 20-year-old - up to 100x higher. If there were to be a single reason, then it would be loss of resilience. Aging is the gradual decline...
Steve Austad Reveals Unexpected Drug Choice for TAME
I asked Steve Austad, if he were designing the TAME trial today, what drug would he pick? His answer may surprise you. Full interview here: https://t.co/npZ3cbD3VE https://t.co/Me6eH2QCZ1
Aging Breakthroughs Outpace Expectations, Human Translation Lags
New Episode of Longevity Science with Steve Austad One of the most important lessons I've learned in aging research is that progress rarely follows a straight line. Twenty-five years ago, Steven Austad made a prediction that many people considered outrageous: that someone...
Dormant Longevity Pathways Reactivated by Clusterin Protein
Long-Living Wild Mouse May Hold Secret to Healthy Aging “And it seems other mice—and humans—may have these pathways too, they’ve just gone dormant for some reason or another. But they can be reactivated by proteins like clusterin.” https://t.co/5FGKxXMTXf https://t.co/YeAUMSZqOW
Integrating Prevention, Care, and Anti‑Aging Science Boosts Healthspan
A recent Aging-US editorial argues that the future of public health will require combining prevention, clinical care, and therapies that target the biology of aging to extend not only lifespan, but also healthspan, resilience, and quality of life in aging...
Time‑Restricted Eating Boosts Health, Sparks Intermittent Fasting Era
Fourteen years ago today, our lab published the first definitive evidence that simply restricting when mice eat—without changing the amount or quality of food—can deliver profound health benefits. That discovery helped launch a new era of circadian nutrition research and...
Semaglutide Slows Biological Aging in HIV Patients
One of the lies I taught in medical school: aging is a separate disease from metabolic disease. A new RCT just complicated that. UC San Diego + TruDiagnostic, randomized double-blind placebo-controlled (Nature Communications, June 2026): adults with HIV on semaglutide showed...
Smart Toilets Detect Hidden Blood, Prevent Early Colon Cancer
Colon cancer is now the #1 cancer killer in Americans under 50. Throne Sciences CEO Scott Hickle, on Health Longevity Secrets: most cases trace back to a signal patients never see -- microscopic blood in the stool, years before symptoms. A...
6.5‑8 Hours Sleep Minimizes Biological Aging
Too little sleep ages you. Too much ages you too. The window is narrower than you think. 500,000 people. Multiple biological aging clocks. Same conclusion. The slowest biological aging showed up around 6.5 to 8 hours of sleep per night. Too little sleep...
Universal Aging Clock Links Mice to Humans via Shared Genes
A new study built one biological-age predictor that holds across mice, rats, macaques, and humans -- and it traces aging back to a small set of shared genes. (1/5)
Cross-Species Cell Atlas Reveals Organelle Resilience for Longevity
Organelle resilience as a comparative blueprint for longevity 🗣️I introduce the Comparative Metabolic Longevity Cell Atlas (CMLCA), a cross-mammalian platform integrating standardized cellular systems, organelle-resolved multi-omics, and computational analysis to identify conserved features of resilience and inform next-generation strategies to improve...
Air Pollution Accelerates Brain Aging, Boosts Dementia Risk
Accelerated biological aging and brain structural alterations linking air pollution to dementia risk: a prospective cohort study "Our findings support the association between air pollution and dementia, as well as a reduction in global and several regional brain volumes. Notably, biological...