First Human Dose Reverses Aging After 25 Years
After 25 years of brave & brilliant work by hundreds of scientists in my lab to understand then safely reverse aging for the first time, it was moving to witness the first human dose being delivered 🥹 https://t.co/veQsyUEORz
New Longevity Rx Platform Offers Proven Anti‑Aging Meds
I just launched a longevity Rx platform. Prescriptions I personally use are there. v1 is live now. Includes access to: + Tadalafil (Cialis) + Metformin + Oral Minoxidil + Tretinoin + Estradiol + Acarbose We’re working with licensed doctors and pharmacies to make these...
Calorie Restriction Lowers C3a, Curbing Inflammaging
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging "complement C3a reduction is a metabolically regulated inflammatory checkpoint that can be harnessed to attenuate inflammaging" https://t.co/UaBPbf7wAe
Longevity Clinics Sell Hype, Not Proven Life Extension
Every few months, a new therapy arrives with the same promise: activate this pathway, inhibit that enzyme, filter your blood, flood your cells with light, and the clock of aging will slow. NAD+ precursors, senolytics, mTOR inhibitors, plasmapheresis, ozone infusions,...
Gene Transfer Challenges Hardwired Lifespan Belief
One of the lies I taught in medical school: lifespan is hardwired and species-specific. A new gene transfer experiment says otherwise. (1/4)
Balance Beats Extremes: Optimize All, Not Just One
Longevity isn't determined by your greatest strength. It's often determined by your biggest weakness. - excellent fitness but poor mental health - good blood markers but poor fitness - excellent sleep but poor bloodwork - perfect diet but still a pooch...
Plant‑based Diets Extend Life for Cardiometabolic Patients Worldwide
Associations of plant-based diets with all-cause and cause-specific mortality and life expectancy among participants with cardiometabolic disorders from UK, USA, and China https://t.co/IAF3t9rEuh https://t.co/Jk4giqyov4
Fasting‑Mimicking Diet Cuts Biological Age, Boosts Health
Dr. Valter Longo is a biogerontologist who created the fasting-mimicking diet (FMD). In studies, the fasting-mimicking diet has been shown to: - Lower PhenoAge biological age score by 2.5 years in 3 months - Regenerate parts of the immune system - Reduce insulin resistance -...
Marrying Into Long-Lived Families Boosts Spouse Health Beyond Genetics
Familial healthy aging and longevity: the role of spouses "Spouses marrying into longevity-enriched families exhibit a substantial and broad health advantage that is not attributable to shared genetic predisposition to longevity or socioeconomic differences." https://t.co/UzWkyMq7Kq
Breakthrough Therapies Extend Survival, Renew Hope for Terminal Illnesses
For those of you who have a terminal illness, a chronic condition, or debilitating health issue, there is new reason to have hope. New treatments are arriving that buy more time for the next to arrive. Even for the most...
Metformin Shows No Impact on Epigenetic Aging in HIV Patients
Metformin and epigenetic age in non-diabetic older people with HIV in Madrid (METFORAGING): a double-blind, randomised, placebo-controlled, pilot trial "...no significant difference was noted in the primary outcome between groups..." https://t.co/gfrIJIq1f8
Steve Austad Forecasts Field’s Future Pride and Regret
I asked Steve Austad what one thing the field will be proud of 10 years from now, and one thing we may be embarrassed about. Full interview here: https://t.co/npZ3cbCw66 https://t.co/8jaZ3wbtZj
Loss of Resilience Drives Age‑related Disease Risk
An 80-year-old has a dramatically higher risk of cancer, heart disease, stroke, and dementia than a 20-year-old - up to 100x higher. If there were to be a single reason, then it would be loss of resilience. Aging is the gradual decline...
Steve Austad Reveals Unexpected Drug Choice for TAME
I asked Steve Austad, if he were designing the TAME trial today, what drug would he pick? His answer may surprise you. Full interview here: https://t.co/npZ3cbD3VE https://t.co/Me6eH2QCZ1
Aging Breakthroughs Outpace Expectations, Human Translation Lags
New Episode of Longevity Science with Steve Austad One of the most important lessons I've learned in aging research is that progress rarely follows a straight line. Twenty-five years ago, Steven Austad made a prediction that many people considered outrageous: that someone...
Dormant Longevity Pathways Reactivated by Clusterin Protein
Long-Living Wild Mouse May Hold Secret to Healthy Aging “And it seems other mice—and humans—may have these pathways too, they’ve just gone dormant for some reason or another. But they can be reactivated by proteins like clusterin.” https://t.co/5FGKxXMTXf https://t.co/YeAUMSZqOW
Integrating Prevention, Care, and Anti‑Aging Science Boosts Healthspan
A recent Aging-US editorial argues that the future of public health will require combining prevention, clinical care, and therapies that target the biology of aging to extend not only lifespan, but also healthspan, resilience, and quality of life in aging...
Time‑Restricted Eating Boosts Health, Sparks Intermittent Fasting Era
Fourteen years ago today, our lab published the first definitive evidence that simply restricting when mice eat—without changing the amount or quality of food—can deliver profound health benefits. That discovery helped launch a new era of circadian nutrition research and...
Semaglutide Slows Biological Aging in HIV Patients
One of the lies I taught in medical school: aging is a separate disease from metabolic disease. A new RCT just complicated that. UC San Diego + TruDiagnostic, randomized double-blind placebo-controlled (Nature Communications, June 2026): adults with HIV on semaglutide showed...
Smart Toilets Detect Hidden Blood, Prevent Early Colon Cancer
Colon cancer is now the #1 cancer killer in Americans under 50. Throne Sciences CEO Scott Hickle, on Health Longevity Secrets: most cases trace back to a signal patients never see -- microscopic blood in the stool, years before symptoms. A...
6.5‑8 Hours Sleep Minimizes Biological Aging
Too little sleep ages you. Too much ages you too. The window is narrower than you think. 500,000 people. Multiple biological aging clocks. Same conclusion. The slowest biological aging showed up around 6.5 to 8 hours of sleep per night. Too little sleep...
Universal Aging Clock Links Mice to Humans via Shared Genes
A new study built one biological-age predictor that holds across mice, rats, macaques, and humans -- and it traces aging back to a small set of shared genes. (1/5)
Cross-Species Cell Atlas Reveals Organelle Resilience for Longevity
Organelle resilience as a comparative blueprint for longevity 🗣️I introduce the Comparative Metabolic Longevity Cell Atlas (CMLCA), a cross-mammalian platform integrating standardized cellular systems, organelle-resolved multi-omics, and computational analysis to identify conserved features of resilience and inform next-generation strategies to improve...
Air Pollution Accelerates Brain Aging, Boosts Dementia Risk
Accelerated biological aging and brain structural alterations linking air pollution to dementia risk: a prospective cohort study "Our findings support the association between air pollution and dementia, as well as a reduction in global and several regional brain volumes. Notably, biological...
Single Gene Links Youthful Benefits to Aging Disease
New in Nature Communications (June 3, 2026): a single gene wires together early-life advantage and late-life disease -- the most direct experimental evidence yet for antagonistic pleiotropy, the aging theory George Williams proposed in 1957. (1/4)
NewLimit Secures $435 Million, Valued Over $3 B
NewLimit, one of the 'epigenetic reprogramming' companies, raised $435 million. Very big number. Second biggest after Altos. Claims payload will be RNA to the liver. Presumably its 1 or more transcription factors carried by LNPs. New valuation >$3 billion....
Cellular Reprogramming Needed to Surpass 120-Year Lifespan Limit
cellular reprogramming is the only path to 150 years old (and beyond). because even if we cured every disease on Earth overnight, you still wouldn't make it to 150. the oldest person who ever lived, jeanne calment, made it to 122, and...
Partial Reprogramming Firms Secure Funding, Launch Clinical Trials
The longevity (aka rejuvenation) companies focused on partial cellular reprogramming are getting more investments and starting clinical trials (eye and liver) @newlimit gets a new jolt, to add to billions invested in @altos_labs, @RetroBio_ , @lifebiosciences, @turn_bio, @ShiftBioscience, @rejuvenatebio, https://t.co/gSsHpQAU1k
Calorie Restriction Cuts Human Biological Aging by 2‑3%
Slowing aging is not theoretical. In humans, calorie restriction measurably slows biological aging pace by ~2–3% over 2 years https://www.nature.com/articles/s43587-022-00357-y
Exercise Revives Aging Muscles Through Mitochondrial Remodeling
Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans "We report that exercise-induced improvements in functional capacity, including reduced frailty in old mice, are dependent on mitochondrial adaptations in skeletal muscle at structural, enzymatic,...
Adipocyte SLC25A51 Controls Mitochondrial Function and Aging Metabolism
The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging https://t.co/4SuyuA0UsH https://t.co/h1nYczP9Jl
Speeding Biomarker Translation: From Research to Affordable Care
Fascinating science, but the real question is translation -how quickly can this move from research into something clinically actionable and affordable at scale? We’ve seen promising biomarkers stall before. #health #aging https://t.co/6qUmSulCxJ
Therapeutic Plasma Exchange Shows Promise for Reducing Biological Age
Is therapeutic plasma exchange (TPE) a legitimate longevity intervention? The rationale makes sense. The mouse studies are intriguing. And we’re just starting to get human data to fill out the picture. In my latest episode of Longevity Science, I sat down with...
Short-Term Diet Shifts Affect Markers, Not Age Reversal
Short-Term Dietary Intervention Alters Physiological Profiles Relevant to Ageing 🔎"[Though] caution is warranted in interpreting such changes as evidence of biological age reversal as observed shifts may reflect acute physiological responsiveness to dietary inputs rather than altered ageing trajectories." https://t.co/kQflQ3i3Kw
Longevity Capped; Prioritize Healthspan over Extra Years
Jeanne Calment died at 122. No one has lived longer. That's not a record waiting to be broken -- it's the biological ceiling we've been hitting for a century. Steve Horvath says it best in the new documentary "Forever Young": the real...
Low CAD Genetic Risk Drives Multigenerational Longevity
Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging https://t.co/mwkzNuRK2D https://t.co/xr1dKT8kjB
Plasma Dilution Boosts Cardiac Repair and Mobility in Aged Mice
Plasma Dilution After Myocardial Ischemia-Reperfusion Injury Promotes Cardiac Repair, Heart Performance, and Recovery of Motor Function and Endurance in Old Mice https://t.co/gKE6dyzbYJ https://t.co/hjKrU0bPxk
Unfiltered's 2026 Longevity Top 100 Ranked
Who runs longevity in 2026? Unfiltered published their top 100 list. Here is the digest with my comments https://t.co/a0hFUmaHZ8 https://t.co/BrcOym0TbT
Clearing Senescent Cells Restores Aged Muscle Recovery
Aging muscle struggles to recover after inactivity partly because senescent cells accumulate in the muscle niche. In aged mice, clearing these cells reduced inflammation, improved muscle regeneration, and restored strength after disuse. #Aging #MuscleHealth #Senescence @WuTsaiAlliance https://t.co/yq8Uss9IbZ
Longevity Linked to Clean Aging, Not Just Slowed Decay
What if extreme longevity is less about avoiding aging and more about aging cleanly? Maria Branyas Morera lived to 117 -- the oldest verified person on Earth. A new multi-omics study in Cell Reports Medicine (Santos-Pujol, Esteller et al) profiled her...
Habits Rewrite Your Genes' Impact, Not Their Code
Genetics is mostly fixed. Epigenetics is dynamic. You cannot change the DNA you inherited. But you can influence how that DNA is expressed through the signals you repeat every day: stress, sleep, food, movement, connection, and recovery. Chronic stress can push biology toward inflammation. Consistent...
Melatonin Cuts Radiation DNA Damage by One‑third
Melatonin has radioprotective effects☢️ In this 2020 clinical study, 5 healthy males aged 25–35 were given 100 mg of melatonin before exposure to 100 mGy of X-ray radiation (equivalent to multiple CT scans) - 1 hour after radiation: 33% reduction in DNA...
Low Oxygen May Extend Lifespan, Study Suggests
The Role of Hypoxia in Longevity "...Hypoxia, marked by reduced oxygen availability, has emerged as a promising area of study within aging research..." https://t.co/HFODDoSw8a https://t.co/a6VWNP7R6F
New Evidence Supports Information Theory of Aging
👏 More exciting evidence for The Information Theory of Aging (ITOA) What is ITOA and why is it a game changer if correct? …
Harvard Study: Body Can Remember Youth, Defy Death
Your Body Can Beat Death, Says One Harvard Scientist—Because It Could ‘Remember’ How to Be Young 🔎 @davidasinclair’s research, circulating now in @PopMech https://t.co/1CKZb4XtnS https://t.co/7U2PRYrKS7
Aging Happens in Two Biological Bursts at 44 and 60
According to a Stanford study, your biology may undergo two major accelerations of aging: - Around age 44 - Around age 60 Dr. Michael Snyder's team analyzed 135,000+ biological markers and found that aging appears to happen in bursts—not a steady decline. Here's what...
Even 10% True: Longevity Research Sparks Revolution
Even if just 10% of what longevity scientists are claiming is true, we are living through one of the most consequential scientific revolutions of our lifetime. That is the conclusion award-winning filmmaker David Donnelly came to after spending three years across...
Centenarians Preserve Gut‑Immune Barrier Unlike Aging
The long-lived immune system of centenarians https://t.co/1o35n3XYj1 Fig. 4: The gut–immune barrier in ageing versus centenarians. 🔽👨⚕️ https://t.co/uCoFS3ZbEG
Track Hidden Biomarkers Before Symptoms Appear
Your annual checkup won’t catch these. I run them on every patient I see, because by the time symptoms show up, these markers have been off for years. Know your numbers before your body makes the decision for you.👏🏻 #longevity #cellularhealth #antiaging #biohacking...
Lift Weights to Naturally Boost IL-15 and NK Cells
Want more IL-15 and NK cells while you are waiting for ANKTIVA? Lift weights. The strongest natural stimulus for IL-15 isn'''t a supplement or a peptide — it'''s resistance training. Your muscles are an endocrine organ pumping out longevity signals that...