Longevity Social Media and Updates

Lymphatic Dysregulation Fuels Aging and Disease
SocialMay 16, 2026

Lymphatic Dysregulation Fuels Aging and Disease

From repair to disease: lymphatic contributions to regeneration, cancer and ageing "...Lymphatic vessel dysregulation drives aging and age-associated diseases, highlighting an urgent frontier for intervention...." https://t.co/w0hztPYH3t https://t.co/2FEk9LaqUT

By David Barzilai, MD PhD
Aging Lymphatics Link Immunity, Brain Health, Therapy
SocialMay 15, 2026

Aging Lymphatics Link Immunity, Brain Health, Therapy

Ageing and the lymphatic system: Implications for immunity, brain health, and possible therapeutic interventions ...A promising target for future gerotherapeutic interventions.... https://t.co/La8hNvp2Z3 https://t.co/w9EbbEtiz6

By David Barzilai, MD PhD
Sample Handling Critically Impacts NAD+ Aging Biomarker Accuracy
SocialMay 15, 2026

Sample Handling Critically Impacts NAD+ Aging Biomarker Accuracy

How you handle blood 🩸samples may dramatically distort NAD+ measurements. Freezing, freeze–thaw cycles, and dried blood spots caused major NAD+ loss. Methanol-based preservation largely stabilized levels—highlighting how pre-analytical methods can shape aging biomarker data. #Metabolism #Aging #NAD https://t.co/BVXXJgT344

By Satchin Panda
Aging and Atherosclerosis: A Two‑Way Mechanistic Link
SocialMay 15, 2026

Aging and Atherosclerosis: A Two‑Way Mechanistic Link

The Complex Bidirectional Relationship Between Aging and Atherosclerosis: Mechanistic Insights and Translational Opportunities https://t.co/RFoxEToDro https://t.co/QKzojgZP5O

By David Barzilai, MD PhD
NAD Levels Remain Stable With Age, Supplements Help
SocialMay 15, 2026

NAD Levels Remain Stable With Age, Supplements Help

New study showing NAD levels don’t go down with age? https://t.co/u7NKPRLwHI Even covered by @NPR https://t.co/ju87xIcK1q… I bet we will see a retraction or correction. Since I started working in longevity in the 1990s, niacin and niacinamide have been standard longevity supplements. Because doctors could...

By Dave Asprey
SIRT6 Overexpression Reverses Liver Chromatin Aging
SocialMay 15, 2026

SIRT6 Overexpression Reverses Liver Chromatin Aging

SIRT6 overexpression counteracts chromatin aging in the male murine liver “Furthermore, AAV-mediated SIRT6 overexpression in aged male mice demonstrates that SIRT6 not only slows age-related chromatin changes but can also reverse them, rejuvenating chromatin accessibility to a youthful state.” https://t.co/fpGJtiOjvL @NatureComms

By David Barzilai, MD PhD
Thymus Role in Health Across Lifespan Redefined
SocialMay 14, 2026

Thymus Role in Health Across Lifespan Redefined

Challenging medical dogma, our understanding of the thymus and its impact on our health throughout lifespan has been completely revamped w/ @HugoAerts @TheLancet https://t.co/Wx4n7zeJwp https://t.co/wq2sgYd5X6

By Eric Topol
Treat Aging Heterogeneity as Signal for Precision Geromedicine
SocialMay 14, 2026

Treat Aging Heterogeneity as Signal for Precision Geromedicine

Encouraging a move toward precision geromedicine 🔑"Only by embracing heterogeneity as signal rather than noise can aging biology be translated into effective, preventive, and truly personalized medicine." 🔗https://t.co/dBw8Nco5rM Commentary by Luigi Ferrucci, Stefano Donega, @AndreaBMaier, Guido Kroemer | @geromedicine

By David Barzilai, MD PhD
Calorie Restriction: Largest Non‑Genetic Lifespan Boost Discovered
SocialMay 14, 2026

Calorie Restriction: Largest Non‑Genetic Lifespan Boost Discovered

In the 1930s, Clive McCay at Cornell University discovered what would later turn out to be the largest non-genetic lifespan extension ever seen in animals. McCay noticed that rats stayed healthier and lived significantly longer when they were fed less food...

By Siim Land
Fat‑Specific GHR Knockout Boosts Anti‑Aging and Metabolic Flexibility
SocialMay 13, 2026

Fat‑Specific GHR Knockout Boosts Anti‑Aging and Metabolic Flexibility

Adipose-Specific GHR Knockout Confers Multidimensional Anti-Aging Advantages via Adipose Tissue Remodelling and Enhanced Metabolic Elasticity https://t.co/wZoeDyYY9I https://t.co/htFFJWl0Rh

By David Barzilai, MD PhD
Testing Metformin, Fisetin, Spermidine Boosts Elder Resilience
SocialMay 13, 2026

Testing Metformin, Fisetin, Spermidine Boosts Elder Resilience

Excited to collaborate in this clinical trial in healthy older adults 🚀 Three geroprotectors (metformin, fisetin, and spermidine) will be tested for resilience promotion after a three-week intervention. Looking forward to seeing how this study unfolds @InflamAge_UoB @news_ub

By João Pedro de Magalhães, PhD
Exploring Aging's Core: Damage-Repair Approach Unveiled
SocialMay 13, 2026

Exploring Aging's Core: Damage-Repair Approach Unveiled

Excited for Vitalist Bay Thu-Sun in Berkeley My talk Fri 10am is on the most important topic in the aging field (see pic). Aubrey at 9am (main stage) & ~9:30 workshop (side room) likely good background for my talk for those...

By Karl Pfleger, PhD
Gut Microbiome Ages, Shifts Dramatically at 56
SocialMay 13, 2026

Gut Microbiome Ages, Shifts Dramatically at 56

The Gut Microbiome Has An Age Clock - And It Breaks Around 56 As a medical school professor, I've taught the gut microbiome for years. But this new analysis just changed the conversation. Researchers analyzed 8,115 fecal metagenomes (and replicated in 2,263...

By Robert Lufkin, MD
APOE2 Variant Boosts Neuronal DNA Repair, Slows Aging
SocialMay 13, 2026

APOE2 Variant Boosts Neuronal DNA Repair, Slows Aging

Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging Research from the Buck Institute reveals that the protective APOE2 variant, already associated with exceptional longevity and reduced Alzheimer's risk, keeps human brain cells genomically stable and resistant to cellular...

By David Barzilai, MD PhD
Crocetin Boosts Cellular Energy, Slows Aging in Mice
SocialMay 12, 2026

Crocetin Boosts Cellular Energy, Slows Aging in Mice

Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice https://t.co/nTMkcOb1Vz

By Michael Lustgarten, PhD
Vascular Senescence Hub: Blood Vessels Drive Systemic Aging
SocialMay 12, 2026

Vascular Senescence Hub: Blood Vessels Drive Systemic Aging

Vascular aging: A central driver of multimorbidity - "Proposes the “Vascular Senescence Hub” hypothesis, where vasculature actively drives systemic aging rather than being a passive victim." - "Evaluates emerging therapies, including senolytics and mitochondrial-targeted antioxidants, designed to target fundamental aging mechanisms." https://t.co/n5gIBMdhuC

By David Barzilai, MD PhD
Sleep First: The Ultimate Longevity Hack
SocialMay 12, 2026

Sleep First: The Ultimate Longevity Hack

This is it. Everything learned spending millions on longevity. From: Your Immortal Unc and Auntie. To: Our Immortal nieces and nephews. 0. Sleep is the world's most...

By Bryan Johnson
Low‑dose Nicotine May Boost Brain Health, Warns Moderation
SocialMay 12, 2026

Low‑dose Nicotine May Boost Brain Health, Warns Moderation

Why nicotine is GOOD for your brain. 🧠👇🏼 For longevity I recommend around 5MG a day. If you use too much nicotine, you can experience thinning of hair or erectile dysfunction. Get a free guide on how to use nicotine correctly at:...

By Dave Asprey
Midlife Vitamin D Linked to Reduced Tau Build‑up
SocialMay 12, 2026

Midlife Vitamin D Linked to Reduced Tau Build‑up

Higher vitamin D levels in middle age are associated with less accumulation of tau, one of the pathological hallmarks of Alzheimer's disease. The strongest protection showed up among those with vitamin D levels at the higher end of the cohort (around...

By Rhonda Patrick, PhD
VO2 Max Peaks in 20s, Declines 5‑10% Each Decade
SocialMay 12, 2026

VO2 Max Peaks in 20s, Declines 5‑10% Each Decade

VO2 max timeline during aging (average levels in the general population): 13–19 - Near peak - VO2 max: ~38–48 (♂), ~30–40 (♀) mL/kg/min - Breaths/min: ~14–20 - Aerobic engine building 20–29 - Peak performance - VO2 max: ~42–52 (♂), ~33–43 (♀) mL/kg/min - Breaths/min: ~12–18 - Best lungs...

By Siim Land
Metformin May Lower Glucose via Gut, Not Liver
SocialMay 12, 2026

Metformin May Lower Glucose via Gut, Not Liver

New paper on a proposed mechanism for how metformin lowers glucose, in Nature Metabolism. For such a widely used drug, the picture has been surprisingly murky. We've thought metformin works in the liver by enhancing glucose metabolism/utilization. But biodistribution and new...

By Martin Borch Jensen
CAG-170 Bacterium Abundant in Healthy, Scarce in Illness
SocialMay 12, 2026

CAG-170 Bacterium Abundant in Healthy, Scarce in Illness

A Gut Bacterium Quietly Linked to Good Health As a medical school professor, I've watched the microbiome field generate countless conflicting findings. This one stood out. A large international study from Cambridge, published in Cell Host & Microbe, identified an obscure group...

By Robert Lufkin, MD
Evening Workouts Enhance Diabetes Control, Reduce Inflammation
SocialMay 12, 2026

Evening Workouts Enhance Diabetes Control, Reduce Inflammation

Timing matters 🕒 For type 2 diabetes, afternoon/evening exercise boosts insulin sensitivity & glycemic control, while morning workouts may raise blood sugar. Later workouts are also linked to lower cortisol, less inflammation & better oxidative capacity. #Diabetes #ExerciseScience @WuTsaiAlliance https://t.co/5Bc0PUAE9O

By Satchin Panda
7 Years, 700 Mg/dL Cholesterol, Zero Coronary Plaque
SocialMay 12, 2026

7 Years, 700 Mg/dL Cholesterol, Zero Coronary Plaque

🚨New Paper: "Seven Years of 700 Cholesterol Without Coronary Atherosclerosis" After 7 years of ~700 mg/dl cholesterol, 0 mm3 total plaque (soft +calcified) after expert analysis and AI-guided quantification. Open-access paper linked below.

By Nick Norwitz MD PhD
Tomatidine Boosts Memory and Cuts Cellular Aging in Mice
SocialMay 12, 2026

Tomatidine Boosts Memory and Cuts Cellular Aging in Mice

Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice https://t.co/jVfshXgzxQ https://t.co/6l86CBdoBC

By David Barzilai, MD PhD
Science Journalism's Optimism Skews Longevity Coverage
SocialMay 12, 2026

Science Journalism's Optimism Skews Longevity Coverage

Appreciate the gift link from Eric. Disagree on conclusion though - if you accept that science journalism is always optimistic, this was solid coverage of longevity by @susandominus. Should have mentioned @newlimit though, and named Cynthia Kenyon.

By Martin Borch Jensen
Digital Aging Twin Links Liver Coagulation to Systemic Aging
SocialMay 12, 2026

Digital Aging Twin Links Liver Coagulation to Systemic Aging

A new computational framework, the Digital Aging Twin, quantifies how different organs age at varying rates and identifies liver-derived coagulation factors as direct drivers of systemic aging, offering a precise tool for personalized aging assessment. agingbiology

By Phys.org Threads
Organ Age Asynchrony Predicts Mortality Risk
SocialMay 12, 2026

Organ Age Asynchrony Predicts Mortality Risk

From ageing clocks to organ networks: Biological age-driven organ asynchrony and inter-organ interactions shaping mortality risk https://t.co/y02SJj7q2q https://t.co/ObuzzNQczW

By David Barzilai, MD PhD
Longevity Experts Prioritize Quality Over Length of Life
SocialMay 11, 2026

Longevity Experts Prioritize Quality Over Length of Life

Main Line Area Experts Take a Fresh Approach to Aging Longevity experts are emphasizing quality of life as the focus shifts from “longer" to “better." @MainLineToday https://t.co/TWv1M9wPMj https://t.co/m3ZzIQHH2O

By David Barzilai, MD PhD
New AI Target Discovery Paper Sets Benchmark
SocialMay 11, 2026

New AI Target Discovery Paper Sets Benchmark

New Paper Alert 🚨: A collaboration with the leading target ID experts in Nature Reviews Drug Discovery. If you are looking to teach your AI target discovery - this is a good place to start. Thanks Peter Kirkpatrick for giving...

By Alex Zhavoronkov, PhD
Measure Biology, Not Trends, to Extend Longevity
SocialMay 11, 2026

Measure Biology, Not Trends, to Extend Longevity

Most people are trying to optimize their health without ever measuring what actually matters. The reality is: aging is a biological process you can track (and in many cases, influence) when you know what to look for. Longevity isn’t built on trends....

By Halland Chen, MD
NAD Supplements Often Mislabelled, Quality Varies Widely
SocialMay 11, 2026

NAD Supplements Often Mislabelled, Quality Varies Widely

Independent testing of NAD supplements like NR & NMN suggests there's considerable variability in the quality and what's on the label doesn't necessarily match what's in the product https://t.co/Q7TlAZE5f8

By David Sinclair, PhD
One‑point Mediterranean Diet Boost Cuts Mortality by 4%
SocialMay 11, 2026

One‑point Mediterranean Diet Boost Cuts Mortality by 4%

Adherence to the Mediterranean diet and all-cause mortality: A systematic review and meta-analysis within the Italian National Guidelines “La Dieta Mediterranea” "Each 1-point MD score increase reduced mortality risk by about 4%." https://t.co/l1VEnyEb29 https://t.co/RU5hAnNG1n

By David Barzilai, MD PhD
Phone‑Free Forest Bathing Cuts Resting Heart Rate
SocialMay 11, 2026

Phone‑Free Forest Bathing Cuts Resting Heart Rate

48 hrs forest bathing this weekend. No phone. Resting heart rate lowered 10%. It was glorious. Have you done that recently?

By Bryan Johnson
Take Control of Your Lifespan With Simple Steps
SocialMay 11, 2026

Take Control of Your Lifespan With Simple Steps

How long do you want to live? There's something you can do about it... https://t.co/uDdQlcNn65

By Dave Asprey
Healthspan over Endless Life: Avoid Tithonus’s Cursed Immortality
SocialMay 11, 2026

Healthspan over Endless Life: Avoid Tithonus’s Cursed Immortality

People are complaining about doctors promoting "healthspan" at the expense of extreme life extension. The myth of Tithonus is relevant here. Made immortal by a goddess, she forgets to give him everlasting youth. He ends up shut into a room unable...

By Antonio Regalado
Low‑dose Cialis May Protect Brain Vascular Health, Curb Dementia
SocialMay 11, 2026

Low‑dose Cialis May Protect Brain Vascular Health, Curb Dementia

ED drugs like Cialis & Viagra, when taken as a low dose daily, can help maintain vascular function in brain and muscle, and are a promising, though still debated, approach for preventing & treating dementias. The human data for Cialis...

By David Sinclair, PhD
Exercise‑induced Exosomes Deliver NAMPT, Boost NAD, Protect Liver
SocialMay 11, 2026

Exercise‑induced Exosomes Deliver NAMPT, Boost NAD, Protect Liver

Interesting new paper: In old mice, exercise releases bubble-like blood vesicles called "exosomes" carrying NAMPT, the enzyme that makes NMN Evidence indicates NAMPT's ability to raise NAD and activate liver SIRT1 may be why exercise counteracts fatty liver and fibrosis 🏃‍♀️🏃‍♂️...

By David Sinclair, PhD
Vascular Dysfunction May Drive Cognitive Decline and Dementia
SocialMay 11, 2026

Vascular Dysfunction May Drive Cognitive Decline and Dementia

Emerging research links vascular dysfunction to cognitive decline in aging & dementia. Reduced blood flow and blood-brain barrier breakdown may play a key role—and could even be causally connected. Understanding this opens the door to new, much-needed therapies. #Neuroscience #Aging...

By Satchin Panda
Decoding Epigenetic Clocks: Pathways Behind Accelerated Aging
SocialMay 11, 2026

Decoding Epigenetic Clocks: Pathways Behind Accelerated Aging

How epigenetic clocks tick: Unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging https://t.co/MU3R25TEu3

By David Barzilai, MD PhD
GrimAge Predicts Mortality in Centenarians Beyond Immune Aging
SocialMay 11, 2026

GrimAge Predicts Mortality in Centenarians Beyond Immune Aging

Advances in precision geriatrics. GrimAge methylation clock works in centenarians. Striking new preprint from the Henne Holstege lab (Yaran Zhang et al., 100-plus Study) in n=247 cognitively healthy Dutch centenarians: GrimAge predicts mortality at extreme old age (HR ≈ 1.6...

By Steve Horvath, PhD
Regular Heat Sessions Cut Heart Risk and Mortality
SocialMay 11, 2026

Regular Heat Sessions Cut Heart Risk and Mortality

Heat exposure increases heart rate, causes vasodilation, improves endothelial function, and can help lower blood pressure over time. One of the landmark Finnish studies showed that people using a sauna 4-7x/week had significantly lower cardiovascular and all-cause mortality risk compared to...

By Thomas Paloschi MD | Dr. Longevity™
Glutamic Acid Boosts Quality of Aged Mouse Oocytes
SocialMay 11, 2026

Glutamic Acid Boosts Quality of Aged Mouse Oocytes

Supplementation of old female mice with glutamic acid (an amino) enhances the quality of aged oocytes

By David Sinclair
Bloodwork Reveals Hidden Aging Stress, Target Cellular Health
SocialMay 10, 2026

Bloodwork Reveals Hidden Aging Stress, Target Cellular Health

Aging well isn’t just about how you look. It’s about how well your body can handle stress every single day. Your bloodwork can reveal a deeper story long before symptoms ever show up 🧬 I put years of research into designing @celltheorylabs to...

By Halland Chen, MD
Hormone Decline at 35 Triggers Perimenopause Stress
SocialMay 10, 2026

Hormone Decline at 35 Triggers Perimenopause Stress

💥 Women age differently than men, and it starts around 35. That’s when your body makes less DHEA and pregnenolone, the anti-stress hormones that keep cortisol in check. Without them, stress runs wild. That’s when perimenopause hits hard: brain dog, fatigue,...

By Dave Asprey
AI's Promise in Biomedicine Hinges on Quality Data
SocialMay 10, 2026

AI's Promise in Biomedicine Hinges on Quality Data

AI is transforming our lives and science, but we need to be realistic about both its promise and its limitations. In biomedicine, one major bottleneck remains data. We need more high-quality data to unlock AI-driven advances. It was a pleasure to speak...

By João Pedro de Magalhães, PhD
Longevity Hype Ignores Limited Healthspan Evidence
SocialMay 10, 2026

Longevity Hype Ignores Limited Healthspan Evidence

Why is there such obsession with extending lifespan when the bigger issue is that average healthspan is 65 years and there are no data (except in super-centenarians) that longer lifespan = longer healthspan (known as compression of morbidity)? https://t.co/w33aRn71cn

By Eric Topol
Aging Is Genome‑Encoded, Systemic, and Modifiable
SocialMay 10, 2026

Aging Is Genome‑Encoded, Systemic, and Modifiable

aging is systems-driven & encoded by the whole genome there are species-specific rates of maturation, preservation & decline that are powerfully modifiable for the worse & subtly modifiable for the better there are also enormous numbers of ppl making claims that are...

By Charles Brenner, PhD
FGF21 Acts in Hindbrain to Modulate Eating During Protein Scarcity
SocialMay 10, 2026

FGF21 Acts in Hindbrain to Modulate Eating During Protein Scarcity

FGF21 signals through hindbrain neurons to alter food intake and energy expenditure during dietary protein restriction https://t.co/U2DzBo2OFj https://t.co/ipZvmcgmDM

By David Barzilai, MD PhD