
Dogs Extend Life Through Walks, Purpose, and Oxytocin
Honored and delighted to be interviewed by Steven Petrow for this article in the Washington Post. It's titled, "Can having a dog boost your longevity? Here's what science says." I talked about how dogs encourage you to walk, at least twice a day, to socialize, as many people like to pet your dog and learn about your dog. Dogs give people a sense of purpose, a reason for getting out of bed in the morning. In fact, your dog often wakes you up, wagging its tail and looking to play. What was not in the article is that dogs can also help you feel good by encouraging you to laugh when they do silly things. When you pet your dog, you release oxytocin, which is a neuropeptide that helps you feel good. It's often called the love hormone. The good news is that the dog's oxytocin also increases, so it feels good, too. Dogs also help us live in the moment and pay attention to the here and now, as they are constantly sniffing, looking, and listening attentively to everything around them. Having a dog is one of the most wonderful things in my life. I feel like Athena, our German Shepherd, is an important member of our family. She brings us great joy each day. Here's the link: https://t.co/pIDLEIXH0E #dogs #pets #health #happiness #dogsarelove #lifestylemedicine #pavingwellness

Lymphatic Dysregulation Fuels Aging and Disease
From repair to disease: lymphatic contributions to regeneration, cancer and ageing "...Lymphatic vessel dysregulation drives aging and age-associated diseases, highlighting an urgent frontier for intervention...." https://t.co/w0hztPYH3t https://t.co/2FEk9LaqUT

Aging Lymphatics Link Immunity, Brain Health, Therapy
Ageing and the lymphatic system: Implications for immunity, brain health, and possible therapeutic interventions ...A promising target for future gerotherapeutic interventions.... https://t.co/La8hNvp2Z3 https://t.co/w9EbbEtiz6

Sample Handling Critically Impacts NAD+ Aging Biomarker Accuracy
How you handle blood 🩸samples may dramatically distort NAD+ measurements. Freezing, freeze–thaw cycles, and dried blood spots caused major NAD+ loss. Methanol-based preservation largely stabilized levels—highlighting how pre-analytical methods can shape aging biomarker data. #Metabolism #Aging #NAD https://t.co/BVXXJgT344

Aging and Atherosclerosis: A Two‑Way Mechanistic Link
The Complex Bidirectional Relationship Between Aging and Atherosclerosis: Mechanistic Insights and Translational Opportunities https://t.co/RFoxEToDro https://t.co/QKzojgZP5O
NAD Levels Remain Stable With Age, Supplements Help
New study showing NAD levels don’t go down with age? https://t.co/u7NKPRLwHI Even covered by @NPR https://t.co/ju87xIcK1q… I bet we will see a retraction or correction. Since I started working in longevity in the 1990s, niacin and niacinamide have been standard longevity supplements. Because doctors could...

SIRT6 Overexpression Reverses Liver Chromatin Aging
SIRT6 overexpression counteracts chromatin aging in the male murine liver “Furthermore, AAV-mediated SIRT6 overexpression in aged male mice demonstrates that SIRT6 not only slows age-related chromatin changes but can also reverse them, rejuvenating chromatin accessibility to a youthful state.” https://t.co/fpGJtiOjvL @NatureComms

Thymus Role in Health Across Lifespan Redefined
Challenging medical dogma, our understanding of the thymus and its impact on our health throughout lifespan has been completely revamped w/ @HugoAerts @TheLancet https://t.co/Wx4n7zeJwp https://t.co/wq2sgYd5X6

Treat Aging Heterogeneity as Signal for Precision Geromedicine
Encouraging a move toward precision geromedicine 🔑"Only by embracing heterogeneity as signal rather than noise can aging biology be translated into effective, preventive, and truly personalized medicine." 🔗https://t.co/dBw8Nco5rM Commentary by Luigi Ferrucci, Stefano Donega, @AndreaBMaier, Guido Kroemer | @geromedicine

Calorie Restriction: Largest Non‑Genetic Lifespan Boost Discovered
In the 1930s, Clive McCay at Cornell University discovered what would later turn out to be the largest non-genetic lifespan extension ever seen in animals. McCay noticed that rats stayed healthier and lived significantly longer when they were fed less food...

Fat‑Specific GHR Knockout Boosts Anti‑Aging and Metabolic Flexibility
Adipose-Specific GHR Knockout Confers Multidimensional Anti-Aging Advantages via Adipose Tissue Remodelling and Enhanced Metabolic Elasticity https://t.co/wZoeDyYY9I https://t.co/htFFJWl0Rh
Testing Metformin, Fisetin, Spermidine Boosts Elder Resilience
Excited to collaborate in this clinical trial in healthy older adults 🚀 Three geroprotectors (metformin, fisetin, and spermidine) will be tested for resilience promotion after a three-week intervention. Looking forward to seeing how this study unfolds @InflamAge_UoB @news_ub

Exploring Aging's Core: Damage-Repair Approach Unveiled
Excited for Vitalist Bay Thu-Sun in Berkeley My talk Fri 10am is on the most important topic in the aging field (see pic). Aubrey at 9am (main stage) & ~9:30 workshop (side room) likely good background for my talk for those...

Gut Microbiome Ages, Shifts Dramatically at 56
The Gut Microbiome Has An Age Clock - And It Breaks Around 56 As a medical school professor, I've taught the gut microbiome for years. But this new analysis just changed the conversation. Researchers analyzed 8,115 fecal metagenomes (and replicated in 2,263...

APOE2 Variant Boosts Neuronal DNA Repair, Slows Aging
Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging Research from the Buck Institute reveals that the protective APOE2 variant, already associated with exceptional longevity and reduced Alzheimer's risk, keeps human brain cells genomically stable and resistant to cellular...
Crocetin Boosts Cellular Energy, Slows Aging in Mice
Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice https://t.co/nTMkcOb1Vz

Vascular Senescence Hub: Blood Vessels Drive Systemic Aging
Vascular aging: A central driver of multimorbidity - "Proposes the “Vascular Senescence Hub” hypothesis, where vasculature actively drives systemic aging rather than being a passive victim." - "Evaluates emerging therapies, including senolytics and mitochondrial-targeted antioxidants, designed to target fundamental aging mechanisms." https://t.co/n5gIBMdhuC
Sleep First: The Ultimate Longevity Hack
This is it. Everything learned spending millions on longevity. From: Your Immortal Unc and Auntie. To: Our Immortal nieces and nephews. 0. Sleep is the world's most...

Low‑dose Nicotine May Boost Brain Health, Warns Moderation
Why nicotine is GOOD for your brain. 🧠👇🏼 For longevity I recommend around 5MG a day. If you use too much nicotine, you can experience thinning of hair or erectile dysfunction. Get a free guide on how to use nicotine correctly at:...

Midlife Vitamin D Linked to Reduced Tau Build‑up
Higher vitamin D levels in middle age are associated with less accumulation of tau, one of the pathological hallmarks of Alzheimer's disease. The strongest protection showed up among those with vitamin D levels at the higher end of the cohort (around...
VO2 Max Peaks in 20s, Declines 5‑10% Each Decade
VO2 max timeline during aging (average levels in the general population): 13–19 - Near peak - VO2 max: ~38–48 (♂), ~30–40 (♀) mL/kg/min - Breaths/min: ~14–20 - Aerobic engine building 20–29 - Peak performance - VO2 max: ~42–52 (♂), ~33–43 (♀) mL/kg/min - Breaths/min: ~12–18 - Best lungs...

Metformin May Lower Glucose via Gut, Not Liver
New paper on a proposed mechanism for how metformin lowers glucose, in Nature Metabolism. For such a widely used drug, the picture has been surprisingly murky. We've thought metformin works in the liver by enhancing glucose metabolism/utilization. But biodistribution and new...

CAG-170 Bacterium Abundant in Healthy, Scarce in Illness
A Gut Bacterium Quietly Linked to Good Health As a medical school professor, I've watched the microbiome field generate countless conflicting findings. This one stood out. A large international study from Cambridge, published in Cell Host & Microbe, identified an obscure group...

Evening Workouts Enhance Diabetes Control, Reduce Inflammation
Timing matters 🕒 For type 2 diabetes, afternoon/evening exercise boosts insulin sensitivity & glycemic control, while morning workouts may raise blood sugar. Later workouts are also linked to lower cortisol, less inflammation & better oxidative capacity. #Diabetes #ExerciseScience @WuTsaiAlliance https://t.co/5Bc0PUAE9O

7 Years, 700 Mg/dL Cholesterol, Zero Coronary Plaque
🚨New Paper: "Seven Years of 700 Cholesterol Without Coronary Atherosclerosis" After 7 years of ~700 mg/dl cholesterol, 0 mm3 total plaque (soft +calcified) after expert analysis and AI-guided quantification. Open-access paper linked below.

Tomatidine Boosts Memory and Cuts Cellular Aging in Mice
Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice https://t.co/jVfshXgzxQ https://t.co/6l86CBdoBC
Science Journalism's Optimism Skews Longevity Coverage
Appreciate the gift link from Eric. Disagree on conclusion though - if you accept that science journalism is always optimistic, this was solid coverage of longevity by @susandominus. Should have mentioned @newlimit though, and named Cynthia Kenyon.
Digital Aging Twin Links Liver Coagulation to Systemic Aging
A new computational framework, the Digital Aging Twin, quantifies how different organs age at varying rates and identifies liver-derived coagulation factors as direct drivers of systemic aging, offering a precise tool for personalized aging assessment. agingbiology

Organ Age Asynchrony Predicts Mortality Risk
From ageing clocks to organ networks: Biological age-driven organ asynchrony and inter-organ interactions shaping mortality risk https://t.co/y02SJj7q2q https://t.co/ObuzzNQczW

Longevity Experts Prioritize Quality Over Length of Life
Main Line Area Experts Take a Fresh Approach to Aging Longevity experts are emphasizing quality of life as the focus shifts from “longer" to “better." @MainLineToday https://t.co/TWv1M9wPMj https://t.co/m3ZzIQHH2O

New AI Target Discovery Paper Sets Benchmark
New Paper Alert 🚨: A collaboration with the leading target ID experts in Nature Reviews Drug Discovery. If you are looking to teach your AI target discovery - this is a good place to start. Thanks Peter Kirkpatrick for giving...

Measure Biology, Not Trends, to Extend Longevity
Most people are trying to optimize their health without ever measuring what actually matters. The reality is: aging is a biological process you can track (and in many cases, influence) when you know what to look for. Longevity isn’t built on trends....
NAD Supplements Often Mislabelled, Quality Varies Widely
Independent testing of NAD supplements like NR & NMN suggests there's considerable variability in the quality and what's on the label doesn't necessarily match what's in the product https://t.co/Q7TlAZE5f8

One‑point Mediterranean Diet Boost Cuts Mortality by 4%
Adherence to the Mediterranean diet and all-cause mortality: A systematic review and meta-analysis within the Italian National Guidelines “La Dieta Mediterranea” "Each 1-point MD score increase reduced mortality risk by about 4%." https://t.co/l1VEnyEb29 https://t.co/RU5hAnNG1n
Phone‑Free Forest Bathing Cuts Resting Heart Rate
48 hrs forest bathing this weekend. No phone. Resting heart rate lowered 10%. It was glorious. Have you done that recently?
Take Control of Your Lifespan With Simple Steps
How long do you want to live? There's something you can do about it... https://t.co/uDdQlcNn65
Healthspan over Endless Life: Avoid Tithonus’s Cursed Immortality
People are complaining about doctors promoting "healthspan" at the expense of extreme life extension. The myth of Tithonus is relevant here. Made immortal by a goddess, she forgets to give him everlasting youth. He ends up shut into a room unable...

Low‑dose Cialis May Protect Brain Vascular Health, Curb Dementia
ED drugs like Cialis & Viagra, when taken as a low dose daily, can help maintain vascular function in brain and muscle, and are a promising, though still debated, approach for preventing & treating dementias. The human data for Cialis...

Exercise‑induced Exosomes Deliver NAMPT, Boost NAD, Protect Liver
Interesting new paper: In old mice, exercise releases bubble-like blood vesicles called "exosomes" carrying NAMPT, the enzyme that makes NMN Evidence indicates NAMPT's ability to raise NAD and activate liver SIRT1 may be why exercise counteracts fatty liver and fibrosis 🏃♀️🏃♂️...

Vascular Dysfunction May Drive Cognitive Decline and Dementia
Emerging research links vascular dysfunction to cognitive decline in aging & dementia. Reduced blood flow and blood-brain barrier breakdown may play a key role—and could even be causally connected. Understanding this opens the door to new, much-needed therapies. #Neuroscience #Aging...
Decoding Epigenetic Clocks: Pathways Behind Accelerated Aging
How epigenetic clocks tick: Unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging https://t.co/MU3R25TEu3
GrimAge Predicts Mortality in Centenarians Beyond Immune Aging
Advances in precision geriatrics. GrimAge methylation clock works in centenarians. Striking new preprint from the Henne Holstege lab (Yaran Zhang et al., 100-plus Study) in n=247 cognitively healthy Dutch centenarians: GrimAge predicts mortality at extreme old age (HR ≈ 1.6...

Regular Heat Sessions Cut Heart Risk and Mortality
Heat exposure increases heart rate, causes vasodilation, improves endothelial function, and can help lower blood pressure over time. One of the landmark Finnish studies showed that people using a sauna 4-7x/week had significantly lower cardiovascular and all-cause mortality risk compared to...

Glutamic Acid Boosts Quality of Aged Mouse Oocytes
Supplementation of old female mice with glutamic acid (an amino) enhances the quality of aged oocytes
Bloodwork Reveals Hidden Aging Stress, Target Cellular Health
Aging well isn’t just about how you look. It’s about how well your body can handle stress every single day. Your bloodwork can reveal a deeper story long before symptoms ever show up 🧬 I put years of research into designing @celltheorylabs to...

Hormone Decline at 35 Triggers Perimenopause Stress
💥 Women age differently than men, and it starts around 35. That’s when your body makes less DHEA and pregnenolone, the anti-stress hormones that keep cortisol in check. Without them, stress runs wild. That’s when perimenopause hits hard: brain dog, fatigue,...

AI's Promise in Biomedicine Hinges on Quality Data
AI is transforming our lives and science, but we need to be realistic about both its promise and its limitations. In biomedicine, one major bottleneck remains data. We need more high-quality data to unlock AI-driven advances. It was a pleasure to speak...

Longevity Hype Ignores Limited Healthspan Evidence
Why is there such obsession with extending lifespan when the bigger issue is that average healthspan is 65 years and there are no data (except in super-centenarians) that longer lifespan = longer healthspan (known as compression of morbidity)? https://t.co/w33aRn71cn
Aging Is Genome‑Encoded, Systemic, and Modifiable
aging is systems-driven & encoded by the whole genome there are species-specific rates of maturation, preservation & decline that are powerfully modifiable for the worse & subtly modifiable for the better there are also enormous numbers of ppl making claims that are...

FGF21 Acts in Hindbrain to Modulate Eating During Protein Scarcity
FGF21 signals through hindbrain neurons to alter food intake and energy expenditure during dietary protein restriction https://t.co/U2DzBo2OFj https://t.co/ipZvmcgmDM