MtDNA Mutations Surge After 60, Unlikely Aging Drivers
Impressive work on mitochondrial DNA mutations with age in blood. However, mutations only appear to accumulate substantially after ~60 years of age. Yet aging occurs earlier, so I don't see these findings supporting the idea that mtDNA mutations are drivers of aging.
FDA Open to Intrinsic Capacity, Demands Sharper IND Proposals
X post Important step forward for geroscience: ARPA-H, XPRIZE, InItiaTe, and the Academy for Geroscience helped sponsor a thoughtful FDA discussion hosted by Reagan-Udall and expertly moderated by Susan. Thanks to Jamie Justice and Andrew Brack for making it happen. The big...
TRPV1 Activation Slows Aortic Aging via ISG15‑p53 Inhibition
Capsaicin Receptor TRPV1 Delays Aortic Aging in Atherosclerotic Mice by Inhibiting the ISG15-p53 Pathway https://t.co/xXBaNEbV45 https://t.co/YaGCtf4EUE
Human Longevity Launches AI Foundation Models with Insil
Thank you Ben Adams and Fierce Biotech for covering Human Longevity's launch of Human Life Foundation Models and the Insilico Medicine collaboration on AI-powered longevity research. https://t.co/iCQbiRKrwc https://t.co/jmOBNHksyX
Reversing Mesenchymal Drift Could Extend Healthspan
With aging, cells lose their identity and undergo a mesenchymal drift. Reversing this drift may be a way to mitigate aging and promote healthspan. A new @CellCellPress review https://t.co/fr4N6b75Im https://t.co/VLtiBVN1NM
Resetting Nuclear Genes Reverses Mitochondrial Aging
We also work on mitochondria. Resetting the nuclear genome can correct some age-related mitochondrial defects, but ultimately we need to address the common issue of clonal hematopoiesis - when some mutations dominate in the blood - and that might include...
Mitochondrial Genome Mutates Sharply Post‑
Mitochondria in our cells have their own genome. A new paper @nature shows it mutates sharply after age 60. Now rare, one day it might be common to receive a mito-transplant later in life 🧬 https://t.co/pEbhh9SWY2
Red Light Therapy Proven for Healing, Anti‑Aging, Pain Relief
Red light therapy or photobiomodulation sounds like a gimmick, but it has legitimate evidence for: - wound healing - skin anti-aging - lowering inflammation and pain - eye health and myopia - bone repair - hair growth Here's what you need to know about red light therapy⬇️⬇️: https://t.co/VfM86JqJzI Graph:...
Suppressing GCN2‑ATF4 Pathway Extends Fly Lifespan
Suppression rather than activation of the integrated stress response (GCN2-ATF4) pathway extends lifespan in the fly https://t.co/3VBtZMHIsy https://t.co/ZAdJTc0bvL
ECM Remodeling and Social Isolation Added as Aging Hallmarks
Hallmarks of aging: Integrating molecular and social determinants 👉The two new hallmarks of aging introduced in the referenced article are extracellular matrix (ECM) changes and psychosocial isolation.👨⚕️ https://t.co/mlmd0E2XmC https://t.co/f7OaLTXXNw
New Stem Cell Subtype Remembers Inflammation, Impacts Prognosis
New @nature. Discovery of a new subtype of blood stem cells—HSC-iM—which have memory to previous inflammation, such as with Covid or aging, and prognostic significance https://t.co/hRfp5xnJGj
Longevity Experts Predict Lifespans Amid Organ Replacement Advances
So many incredible parts from this @SarahLizChar dispatch at a longevity conference, including organ replacement and her survey of how long these people think they'll live. https://t.co/2Pg55oXdV0 https://t.co/IpMq55atJB
Cross-Species Transcriptomic Clocks Enhance Disease Risk Prediction
Just published @Nature Very impressive study of gene expression and hallmarks of aging across 4 mammalian species (including humans), by @gladyshev_lab. Transcriptomic clocks add to epigenetic, organ and cellular clocks for predicting health outcomes. Example of a few proteins found with...
Micronutrient Sufficiency May Curb Inflammaging via Gut Health
Inflammaging and the role of micronutrients as immunomodulators: a pathway to healthy aging "Micronutrient sufficiency may help reduce digestive inflammation, restore microbial balance, and modulate immune pathways implicated in inflammaging. However, translating these benefits requires robust assessment of micronutrient status and...
Top Blood Panel Scores Me #1 on Longevity Clock
Did a comprehensive blood panel - one of my best ones yet All results down below ⬇️⬇️ With this, I ranked #1 at the Longevity World Cup on the BortzAge clock (-21.1 from chronological age) Full interview about the results: https://t.co/AznAbdqYlT https://t.co/VbMGYG2lK1
Harvard Releases First Comprehensive Longevity Report
Tweet 1: Harvard Medical School has just published its first-ever Special Health Report on Longevity. I served as Medical Editor. The first time an institution at this level has done a comprehensive treatment of longevity science for a mass audience. Full announcement: 🔗https://t.co/4L0fIJLSYb
Supplement Users Show Reduced Epigenetic Biological Age
Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals @Aging_Scientist Vincenzo Sorrentino, Jan Gruber, @BKennedy_aging @Aging_Cell: “Supplement users have lower epigenetic biological age than non-users. Several supplements or supplement classes are associated with some benefit on epigenetic age in...
Accelerated Biological Aging Boosts Dementia Risk, APOE‑Linked
A large study found that accelerated biological aging measured through COMMON blood markers was strongly associated with increased dementia risk, especially vascular dementia, with the highest risk seen when combined with high-risk APOE genetics. https://t.co/xBbVl4yyhf
Wearables Could Power AI-Driven Aging Research
Wearables are now abundant enough to generate population-level health data outside of clinical trials. So when will all this data produce progress? When we address the gaps between wearable data and what we need to understand disease. They measure physiology continuously, but...
Targeting Gut‑Microbiota‑Senescence Axis to Combat Degeneration
Regulatory Mechanisms of Age-related Degenerative Diseases: Insights from the Gut Microbiota-Cellular Senescence Interaction Network "This review systematically dissects this [brain-gut] interaction network and its pathogenic role in major degenerative diseases, and highlights precision targeting of this network as a promising strategy...
Four Muscle Groups Forecast Your Post‑60 Aging
Im a bioscientist studying aging. 🧑🔬 These are the 4 muscle groups that predict how you’ll age after 60 👇
Spermidine Reduces Immune Aging, Enhances Vaccines in Elders
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study https://t.co/0bDkrx4Dbe
Fisetin Senolytic Restores Aged Endothelial Function via CXCL12
Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12 "These results identify the SASP and CXCL12 as drivers of age-related endothelial dysfunction and establish mechanisms of senolytic intervention with fisetin supplementation." https://t.co/LNug76rpcN
Ultra‑novel Drugs Needed to Add Years of Health
It was a great pleasure to speak with @business live during the JP Morgan conference. Check out the latest on AI R&D productivity, #MMAIGym, and, most importantly dual-purpose aging and longevity therapeutics. Longevity should be our common purpose -...
AI Transforming Longevity and Drug Discovery at BIO2026
I will be at BIO #BIO2026 speaking on AI for longevity and AI for drug discovery https://t.co/hgLiNih8r1 https://t.co/JAG41qB4jQ
Sponsoring Caltech Longevity Hackathon Highlights AI for Longevity
Very happy to sponsor the Caltech Longevity Hackathon focused on AI for longevity organized by @AndreaVOls who also founded the @cit_longevity Club . Caltech Students are the future of tech. These are the people who know how...
700+ Longevity Biotech Firms Mapped in New Atlas
This, from Rob Sheko 👨⚕️ 👉Longevity Biotech Atlas: Mapping > 700 organizations across the longevity ecosystem⚡️ 🔗https://t.co/ZdxKoX2IWn https://t.co/NOqmGKzIMr
Boosting TTP Reverses Frailty and Bone Loss in Elderly Mice
New in Aging and Disease: scientists boosted a single protein in elderly mice and the animals got measurably stronger, less frail, and built denser bones. The protein is tristetraprolin, or TTP. Its job is to silence inflammatory messages inside cells before...
New Study Challenges Popular NAD+ Longevity Claims
New Research Upends the Argument for a Popular Longevity Supplement A central claim about N.A.D.+ isn’t as straightforward as influencers make it out to be. By @SmithDanaG https://t.co/RhSBkb0oD7 https://t.co/35Qyxwy0Bk
New Study Debunks NAD+ Supplement Anti‑Aging Claims
As a medical school professor, I have watched the NAD+ supplement market explode on the promise that boosting your blood NAD+ slows aging. A new Nature Metabolism paper just punched a hole in the premise. (1/4)
Mitochondrial DNA Stability Crucial for IGF‑1 Longevity Benefits
The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome [ "These observations suggest that mtDNA mutations represent a major barrier to life span extension and that mitochondrial function is required for the successful activation of...
Your 20s Can Heal Pandemic Damage Through New Inputs
If you're in your 20s and you want to feel unstoppable, this is for you... Let's be honest. Your generation got screwed. More anxiety, more depression, less fertility, lower IQ than any generation before you. And most of it traces back...
Leukemia Drug HHT Delays Aging, Extends Mouse Lifespan
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice [an FDA-approved anti-leukemic drug; authors found that "HHT treatment delays aging and extends the lifespan in progeroid and aged mice"] https://t.co/LEegM8XUtR
Longevity Expert Dr. Charlop Joins FOX Business Roundtable
Dr. Gregory Charlop here. I’m excited to announce I’m a featured longevity expert on FOX Business. I’ll be appearing on the Barron’s Roundtable to discuss common-sense health solutions for executives and family offices.
First FDA‑approved Longevity Drug Targets Dogs First
NEW Exclusive Interview: This miracle pill could make dogs live longer, with Celine Halioua, Founder & CEO of Loyal @celinehalioua is building the first drug ever FDA-approved for lifespan extension itself — starting with dogs. We sat down on Onward to...
Centenarians Retain Youthful Immune Profile, Hinting at Longevity
Centenarians show immune function found in younger individuals. Their immune system show reduced inflammatory signaling, enhanced autophagy, and controlled cellular senescence. They have low or no autoimmune disease, robust immunity against cancer and a distinct immune cell profile. Together, these...
Plasma Spermidine Mirrors Diet Slightly; Muscle Levels Regulated
"Spermidine, a polyamine abundant in plant-based and fermented foods, has been associated with reduced cardiovascular and all-cause mortality. However, whether dietary spermidine intake is reflected in circulating and skeletal muscle concentrations remains unclear, and tissue data are scarce... These findings...
2026‑2035 Longevity Metatr
I've spent decades studying exponential tech, and this longevity report is one of the most important I've done. My 2026–2035 Longevity Metatrends Report covers the breakthroughs that will redefine healthspan, performance, and the meaning of aging. Read it here: https://t.co/mLVBlpmmCg
Unproven “Mitochondrial Activator” Risks Echo Deadly DNP
Some functional medicine doctors are prescribing a drug with essentially zero human safety data. The drug is called SLU-PP-332. It’s being marketed in some circles as a “mitochondrial activator” or exercise mimetic. Here’s the problem: as far as I can tell, there...
Longevity Biotech Matures: Precise Indication‑Focused Drug Development
The longevity biotechnology field is coming of age in the best possible way. A recent analysis captures how the sector has learned to speak pharma’s language fluently—moving from broad claims about “slowing aging” to precise, indication-focused drug development with conventional endpoints,...
Methylene Blue: From Dye to Mitochondrial Therapeutic Breakthrough
As a medical school professor, I have watched methylene blue go from a 19th-century dye to a serious mitochondrial story. A new paper adds a striking chapter. (1/4)
Ovarian Age Clocks Predict Menopause Years Early
Know Exactly When You Stop Ovulating As a medical school professor, I keep coming back to one number women have never had access to: when your ovaries will actually stop. A new generation of "ovarian age clocks" — blood-based and follicular markers...
Genes Only Explain Up to Half of Lifespan
5 Longevity Myths the Latest Science Has Just Debunked As a medical school professor, I just published a piece walking through 5 longevity beliefs that the latest peer-reviewed evidence has flipped. 1. "Your genes determine how long you live." A 1996 twin...
Meet Kate Tolo: First Ultra‑Measured Woman for Free Health Data
We now have a female Bryan Johnson. It’s Kate Tolo. She will become the most measured female in history. +$2 million of spend per year + Developing a female-specific protocol + Sharing everything for free To start, she will spend 3 months mapping her baseline....
Essential Anti‑Aging Habits Most People Overlook
The “anti-aging stack” most people miss: - getting lean (3,500 mg of dietary potassium a day
Exercise Remodels Mitochondrial Quality Control to Slow Aging
The role of exercise-mediated mitochondrial quality control remodeling in aging https://t.co/EYmKmjpRDA Mechanisms by which Different Exercise Modes Regulate MQC to Delay Aging. 👇👨⚕️ https://t.co/Dz5bQtrExK
Blood Reveals and Controls Aging Mechanisms
Blood as the mirror and modulator of aging: mechanistic insights and rejuvenation strategies https://t.co/WayE8XIBWp https://t.co/dZt8wHQ2yp
Quality Over Quantity: Making Future Years More Capable
Protect Your Future Self: The Real Strategy Behind Longevity – Interview with Dr. David Barzilai, founder and CEO of Barzilai Longevity Consulting and Lecturer at Harvard Medical School 👉The real win isn't more years. It's more capable years.👨⚕️ https://t.co/jkvbggX9s1 https://t.co/KJX7KqIRZO
Reading Boosts Cognitive Reserve, Cuts Alzheimer Risk 38%
A Lifetime of Reading and Learning Linked to 38% Lower Alzheimer's Risk As a medical school professor, I have watched cognitive reserve go from a fuzzy idea to a measurable signal. A new study just put hard numbers on it. (1/5)
Calorie Restriction Deactivates Complement C3a, Slowing Inflammaging
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging Complement C3a reduction is a metabolically regulated inflammatory checkpoint that can be harnessed to attenuate inflammaging. https://t.co/UaBPbf84pM