Prioritize Healthspan over Chasing Immortality
As a longevity scientist, I’m not interested in helping people live forever. I’m interested in helping people avoid the long period of decline and chronic disease that has become normal in the final 10–20 years of life. Extend healthspan - and a longer, better life follows naturally.
Interferon Pathway Drives Inflammaging, Offers Epigenetic Target
We've known inflammaging is a big part of why the human aging process accelerates. Now the interferon pathway is invoked as having a causal role (via epigenetics) and potential for targeting https://t.co/0Di0xiLGyy
Ultra-Processed Foods Boost Death Risk for Cancer Survivors
As a medical school professor, this study should be front-page news. Researchers tracked cancer survivors and found those eating the most ultra-processed food had: -- 48% higher risk of death from any cause -- 57% higher risk of... https://www.youtube.com/@RobertLufkinMD https://www.aacr.org/about-the-aacr/newsroom/news-releases/high-consumption-of-ultraprocessed-foods-may-be-linked-to-cancer-survivors-risk-of-death/ CancerPrevention #UltraProcessedFood #MetabolicHealth #Nutrition #Longevity
Stable Weight Maintenance Predicts Longer Lifespan in Mice
Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice "We observed that the ability to maintain stable body weight, despite fluctuations in energy intake and expenditure, was positively associated with lifespan in an...
Super‑agers Defy Aging: Brains Stay 25‑year‑old Sharp
‘Harvard Thinking’: How super-agers keep their brains young Experts break down ‘biological contradiction’ of a 65-year-old with the memory of a 25-year-old — and what that means for the rest of us https://t.co/29qpNudp1J https://t.co/X951FiSfiS
Taurine Leads Supplement Tierlist, BCAAs Bottom
Supplement tierlist: - Taurine: 9/10 - Glycine: 8.5/10 - CoQ10: 8/10 - Lutein & zeaxanthin: 7/10 - Ginger: 6/10 - Inositol: 5/10 - Multivitamin: 4/10 - Beta-carotene: 3/10 - Tribulus terrestris: 2/10 - BCAAs 1/10
High SHBG Increases Sarcopenia Risk; Free Hormones Protect
Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women’s Health Initiative "Among postmenopausal women, higher SHBG concentrations at baseline were associated with lower lean body mass and a higher odds of sarcopenia,...
Peptide Hype Stalls Until IQ>70 Hits Market
Peptide bros can’t shut up about BPC-157, TB-500, CJC-1295, etc etc. Just wait until you guys try IQ>70.
AI Creates Orexin Activator to Boost Focus, Reduce Sleep
Two researchers just used AI to design a selective orexin activator. If you care about focus, steady energy, or needing less sleep, this is worth paying attention to. https://t.co/3qbzB6J7X3
Mitochondrial Transplantation Reverses Cell Degeneration
In terms of my top bets for rejuvenation-based therapies, mitochondrial transplanation has entered the chat Cell-type-targeted mitochondrial transplantation rescues cell degeneration https://t.co/izvDaRk7kz
Cellular Stress Drives Stem Cell Aging, Revealing Therapy Targets
Beyond Cell Death: The Hidden Drivers of Stem Cell Aging “The findings shed light on how cellular stress shapes stem cell aging and highlight potential pathways for developing therapies to counter age-related decline...” https://t.co/hBUchsNtQ4 https://t.co/6HyOSZZ6ZS
Reversing Aging Could Halt Chronic Disease Progression
Aging is the primary driver of most chronic diseases. But what if aspects of aging can be reversed? I join @TomBilyeu on Impact Theory to discuss the latest about what we’re learning in the lab and in human clinical trials Full conversation:...
Stress‑induced Mitochondrial Condensate Fusion Drives Aging
It works by phase separation, where mitochondrial DNA and proteins cluster into droplet-like biomolecular condensates that organize gene activity, but under stress these droplets fuse and grow abnormally, disrupting function and contributing to aging. https://t.co/dRzhFVzxQQ
Better Health Can Shrink Your Sleep Needs
Some people actually live longer while sleeping less than eight hours a night. Improve your health, and your sleep requirement often drops. https://t.co/hkfVvcsD4t
P21⁺TREM2⁺ Macrophages Drive Inflammaging and Liver Disease
Delighted to be part of this study identifying p21⁺TREM2⁺ senescent macrophages as drivers of inflammaging and metabolic liver disease. A fantastic collaboration led by @ACovarrubiasPhD 👏
Sauna Benefits Require 31 Minutes to Trigger HSPs
Most people might miss the biggest benefit of sauna You need to get really really hot… Your core body temperature needs to hit 102.4°F (39°C). For reference, a fever is anything above 100.4°F (38°C) So I swallowed a temperature monitoring pill. It goes through...
Ancient Pomegranate Remedy Validated by Modern Science
Pomegranates have been used by Persian and Greek doctors for thousands of years to improve vitality, and modern science is finally catching up to why. https://t.co/6Ei5AXfk1Y
High‑Resolution TORC2 Structure Opens Path to Age‑Related Therapies
Activating TORC2 holds potential in medicine for treating age-related memory & hearing loss. New study out today @MolecularCell reveals the structure of TORC2 in highest-ever resolution - which is good news for drug developers & all of us who age...
DNA Circles in Cancers Show Accelerated Epigenetic Aging
30 years ago, we discovered circular DNA molecules 1. pinch off yeast chromosomes 2. multiply 3. sequester epigenetic regulators (eg sirtuins) 5. cause aging New review today @CellCellPress about DNA circles in human cancers - which are epigenetically older than normal cells https://t.co/VlkBWCFnPi
Ageing Happens Unevenly Across Organs, Not Uniformly
Mosaic ageing: from organ-specific decline to the cause of death “A growing body of biomedical and evolutionary studies increasingly questions the notion of uniform ageing: rather than a whole-body (single) trajectory, ageing appears to occur unevenly across organs, tissues and even...
US Study Links Telomere Length to Genes, Traits, Geography
Genomic, phenomic and geographic associations of leukocyte telomere length in the United States [Mar 27, 2026] @NakaoTetsushi et al. @NatureGenet https://t.co/3b75zEElAP https://t.co/jWNwYRWkQv
First Large Rapamycin Trial Aims to Boost Human Healthspan
Finally—this is the kind of study the field has been waiting for. A 720-person randomized clinical trial testing low-dose rapamycin in adults 65+ is about to get underway at @UAZPharmacy , with the goal of answering a simple but critical question:...
Your 40s‑50s: Crucial Years for Lifelong Health
As a longevity researcher, I can’t stress this enough: Your 40s and 50s are one of the most influential periods for shaping long-term health and age-related disease risk. The key is simply finding your version of the basics you can sustain -...
MLKL Damages Mitochondria, Accelerates Stem Cell Aging
New evidence shows that MLKL, a protein linked to cell death, drives hematopoietic stem cell aging by damaging mitochondria rather than killing cells, highlighting a novel target for preserving blood and immune health. stemcells
Build Muscle to Beat Insulin Resistance
The principle mechanism to overcome insulin resistance in this setting is to increase your onboard glucose management system — AKA skeletal muscle mass 👏🔥👊💪
Infrared Light Essential for Health, Modern Life Deprives It
Infrared light is critical to health and longevity It penetrates through clothes deep into the tissue to: - support energy production - stimulate neurons - improve vascular function - help with skin rejuvenation - stimulate stem cells - support wound healing - lowers inflammation Unfortunately, modern living conditions are...
Three-Day Fast Triggers Free Longevity Boost via Autophagy
The best longevity drug in history is totally free. It's called autophagy. Several things happen when you do a 3 day fast: - your body cannibalizes bad cells / pre-cancer cells / heart plaque - gene expression changes at the 72 hour mark and...
Accelerated Biological Aging Raises Dementia Risk in Women
Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study "In this cohort study of older women, accelerated biological aging measured by AgeAccelGrim2 was associated with higher risk of incident MCI/probable...
AI Promises Optional Death by 2030
AI Can Make Longevity Real | Death Optional by 2030! https://t.co/E9M6hX47Aw #ArtificialIntelligence #Longevity #Immortality #Aging #MedicineOfTheFuture https://t.co/mHpaEZZKKd
Aged Polystyrene Microplastics Speed Worm Aging via Ferroptosis
Photoaged Polystyrene Microplastics Accelerate Aging in Caenorhabditis elegans via Ferroptosis-Linked Insulin Signaling Pathway https://t.co/gGPlKDdgW1 https://t.co/NZ31ToOTp2
Testing Tirzepatide‑CJC1295 Combo to Balance Side Effects
Just spent over an hour with my clinical team debating which growth hormone peptide protocol to run. Still torn. Wanted to share the thinking and get your take. The goal: Increase GH and IGF-1 to support anabolism, recovery, and sleep, but...
Clonal Haematopoiesis Reveals New Insights Into Aging Biology
Ageing Through the Looking-Glass: The Different Flavours of Clonal Haematopoiesis "...how CH enhances our understanding of the biology of ageing." https://t.co/9MKGZIakFY https://t.co/noyHAviY3E
Call for Third‑Party Testing to Certify Peptide Purity
It would be interesting if there was third-party testing and authorization for peptides the same way there is for supplements. An external stamp of purity and authenticity.
Questioning Geroscience: Shingles Vaccine Shows Unexpected Effects
i don’t believe there is an evidence basis for the value proposition of the geroscience hypothesis shingles vaccination was targeted to a specific virus yet this one intervention prevents Alzheimer’s disease and increases all cause mortality is the geroscience hypothesis...
Scientists Explore Possibility of Slowing Human Aging
Can aging be slowed? Some academic scientists think so with @NirBarzilaiMD, @mkaeberlein, and @sessi73 https://t.co/1EoZ7evdDF @AAMC https://t.co/StDgRGSRqr
First Five Get $99 Vitalist Bay 2026 Pass
Courtesy @adamgries... @VitalistBay 2026: 🗓 May 14-17 🔗https://t.co/5dh7N2M7bv "The first 5 can use the code LI-T-MINUS-30 for $99" 🎤 110+ speakers across 6 tracks 🛠 60+ hands-on workshops 🧘 20+ activations running all day, every day" https://t.co/JMMNaUHMIs
FDA Reverses Ban on 12 Peptides for Review
So... @SecKennedy just announced that 12 peptides the Biden FDA shoved into "Category 2" — effectively banning them from regulated compounding pharmacies and driving people to the black market - are being pulled back for legitimate scientific review. Here's what each one...
Sleep Under 7 Hours Cuts Life Expectancy Like Smoking
Sleep isn't a nice-to-have. It's a survival requirement. A major new study from OHSU found that getting less than seven hours a night was more strongly linked to decreased life expectancy than pretty much everything but smoking. Fix your sleep...
Free Blood Biomarker Testing Empowers Early Health Intervention
You can now get your blood work at cost. We launched a biomarkers testing platform. I make $0 on it. Blood testing needs to be more accessible. Instead, we wait until we get sick. And in the meantime, companies...
15 Bioscientist Habits to Tame Silent Inflammation
Chronic inflammation is silent — but it’s a key driver of many age-related diseases. 🧬 Here are 15 habits I prioritise as a bioscientist to keep it in check ↓
Discover Cutting‑Edge Stem Cell Advances at BEYOND 2026
The best place to learn about the latest stem cell research is at BEYOND, Austin, TX, May 27-29, 2026. Learn all the new ways stem cell research is growing and becoming more available from @stemcellchristian at the BEYOND Biohacking Conference. https://t.co/e04Xnfyjwa
Dietary Restriction Extends Lifespan via Conserved Molecular Pathways
Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species https://t.co/JodR3q7w2z https://t.co/46npim9J0m
Booster Speed-Processing Training Cuts Dementia Risk 25%
This one type of cognitive training might delay dementia.🧠🧠 In the ACTIVE randomized controlled trial, older adults were assigned to memory, reasoning, or speed training — then they were followed for 20 years. Standard memory and reasoning training didn't reduce dementia risk....
Statins Don't Harm Muscle Health in Older Adults
Statin use does not impair muscle health in older adults: findings from the SCOPE study https://t.co/WKjk9Ov0rG https://t.co/xTo9mk3vbw
Recovery Becomes Your Superpower as Performance Slows
Recovery is a superpower... A thread... 1/There's a moment most aging athletes eventually hit. You finish a routine workout, but the next day, something is off. You're not just tired. You're slower. Less inclined to train. Your body is responding differently to...
Muscle Atrophy Driven by Intrinsic Aging, Not Nerve Damage
I teach medical students that nerve damage causes muscle wasting. New research says we had it backwards. Scientists at MDI Biological Lab engineered "atrofish" -- zebrafish that compress DECADES of human muscle aging into weeks by activating the Atrogin-1 gene. What they...
FDA Panel to Consider Expanding Peptide Access
FDA panel will meet to discuss allowing broader access to certain peptides https://t.co/PDWKvmvvUH via @LizzyLaw_
AI-Driven Global Collaboration Needed for Longevity Research
Great speaking with @SpeakerPelosi at @semafor . In my opinion, drug discovery for cancer and age-related diseases should be a global effort. Nations need to strive to collaborate to extend healthy productive life. Please through longevity. It is the best...
Electromagnetic Gene Switch Extends Lifespan in Progeroid Mice
Wow, a technique that allows electromagnetic control of gene expression in vivo 🤯 And they tested their system with OSK partial reprogramming, showing it extends lifespan in progeroid mice. In normal mice, they report health improvements and a small reduction in mortality...
Longevity Comes From Simple Daily Habits, Not Extremes
I hate to break it to you, but the world’s longest-living people aren’t doing anything extreme. They move daily, eat mostly whole foods, sleep consistently, and have strong social connections. Boring. Effective. Evidence-based.