New DNA Region Ties Frailty to Brain, Immunity
A newly identified DNA region and two related genes link frailty to both brain and immune function, offering fresh insight into the biological mechanisms that shape aging risk and potential pathways for early detection. genetics
Melatonin Spikes Growth Hormone, Amplified by Resistance Training
Taking 5 mg of melatonin raised growth hormone by 157% within 40 minutes. When resistance training was performed 60 minutes after ingestion, GH rose again - reaching a 132% increase by the 83rd minute. Exercise alone (placebo group) likely increased GH by...
Unlocking Immortality: Professor Cordeiro’s Billion-Dollar Longevity Secrets
Please Don't Die - Interview with Professor José Cordeiro @BillionairePal https://t.co/sVpgpZlSbD #longevity #neverdie #thebilliondollarsecret https://t.co/EsrUaB6ME7
Blocking PGAM‑Chk1 Kills Senescent Cells, Eases Lung Fibrosis
Researchers found that senescent cells depend on a PGAM–Chk1 interaction to boost glycolysis and survive, and blocking this interaction selectively kills these cells and reduces disease effects like lung fibrosis. https://t.co/VTsHTkBcad
SIRT6 Controls Brain Protein Homeostasis, Slowing Aging
SIRT6 Regulates Brain Protein Balance and Aging https://t.co/prPtswc8kh @bengurionu Further reading (primary source) @Aging_Cell: SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling https://t.co/w1SfUiUxg4 https://t.co/TA9UjYkxvN
Under 5 Hours Sleep
"...people who sleep fewer than 5 hours per night had a 50% increased risk of developing coronary heart disease and a 15% increased risk of having a stroke." page 86 in the Lifestyle Medicine Pocket Guide. Sleep is a...
Inflammation, Not Cholesterol, Drives Heart Disease
I've been saying this since 2011. Inflammation drives heart disease. Cholesterol is a passenger. Under 1 = good. Over 3 = something is on fire. Order the test online for $30. Don't wait for your doctor to catch up. Better yet, join @unlimited.life for...
Aging Mechanisms Are Now Engineerable, Says SynBioBeta
Aging isn't just inevitable decline. It's a set of biological systems that are starting to look engineerable. #SynBioBeta2026 is May 4-7th in San Jose, California, you can learn more about the conference and get your tickets here: https://t.co/8abYWJ1GbK DNA damage accumulates. Protein...
World's First Longevity Board Launched to Accelerate Aging Therapies
I am very happy to report that we formed the world's first Longevity Board at the public biotechnology company. Our objective is to discover and develop longevity therapeutics with pipeline-in-a-product potential. GLP-1 therapeutics paved the way and demonstrated the path...
Four Molecules Boost Mouse Lifespan 33% Without Diet Change
They said it was unproven. It's published now. Mice. Western diet. No lifestyle changes. Just four molecules and 33% more life. https://t.co/ctPE6QgjEq
NMN Eases Liver ER Stress, Resets Circadian Rhythm
Nicotinamide mononucleotide attenuates hepatic endoplasmic reticulum stress and modulates circadian rhythms in young mice with diet-induced obesity https://t.co/mXbwdQlAzt https://t.co/iQxPG0NKYf
Centrum Silver’s Anti‑aging Claim Rests on Limited Evidence
Have ya’all heard the breathless news that daily multivitamin use slows down biological aging and preserves memory? Celebrity wellness influencers like Dr. Rhonda Patrick claim that the COSMOS study found Centrum Silver improved memory and slashed aging by 4 months...
Justin Rebo's KindBio Grows Organs On Demand
The Man Growing Organs On Demand Justin Rebo, KindBio and their fantastic sacks 🔗https://t.co/ed4bZbZV0T @Justin_Rebo https://t.co/nCffjjaqJH
Diet Can Reverse Phosphatidylcholine‑driven Mitochondrial Aging
Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging "a previously unrecognized natural driver of mitochondrial decline in aging that is malleable by dietary interventions." https://t.co/jICV37bT1N https://t.co/DxBCO7WXJa
Senolytics Fail to Reset Senescence DNA Methylation Marks
DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment https://t.co/uemETuWkqI H/T @NataliaMitin
Racket Sports Slash Mortality, Boost Heart and Brain Health
Racket sports are linked with some of the largest reductions in all-cause mortality among common physical activities. The mix of short intense bursts, brief recovery, balance, coordination, and fast reactions is great for heart and brain health. Take this as...
Three Key Nutrients for Brain Longevity, Plus Polyphenols
As a bioscientist studying aging, my top 3 nutrients for brain longevity are: → Omega-3s (fatty fish 2–3x/week) → Vitamin B12 (beef, dairy) → Choline (2 eggs daily) Plus plenty of polyphenol-rich foods: berries, extra virgin olive oil, cocoa, nuts, and coffee.
Doctor’s Insider Tips to Ease NAD IV Experience
Feel “weird” during an NAD IV? Here are the insider tips from a top doctor, @joseph_purita, to make things smoother:
First Trial Shows Best‑in‑Class NLRP3 Inhibitor Promise
Excited to complete our first clinical trial for BGE-102. Clinical data supporting best-in-class potential, built on new chemistry and a novel binding site targeting NLRP3 - a central driver of of chronic inflammation in aging. On to Phase 2!
High Sodium Accelerates Memory Decline in Older Men
Higher sodium intake is associated with episodic memory decline in cognitively unimpaired older males: A 6-year longitudinal study https://t.co/8snYRP7sRR https://t.co/kDhs9b2Y8s
AI-Driven Medicine and Cars to Extend Productive Life
Extending human productive life and restoring lost function should be the ultimate objective of AI-powered discovery medicine. It was a great pleasure to share some the story, current progress and long-term plans at one of the most impactful events of...
Muscle Mass Predicts Older Adults' Survival Better than BMI
Muscle mass is a stronger predictor of survival than BMI in older adults Read here: https://www.sciencedirect.com/science/article/abs/pii/S0002934314001387
Curing Disease Adds Years; Slowing Aging Adds Decades
In the future, very few will die from cancer and heart disease. But it's estimated that eliminating both completely only increases life expectancy by ~5–10 years. The real dramatic gains in life expectancy will be achieved by figuring out how to slow...
Research Shows Nicotine May Boost Cognition, Guard Against Parkinson's
The New York Times mentioned me in an article about nicotine. They're skeptical. Here's what they didn't include... Dr. Paul Newhouse at Vanderbilt ran controlled trials showing nicotine improved concentration and cognitive function in people with mild cognitive impairment. Peer-reviewed, published...
High‑Intensity Training Linked to Greater Brain Atrophy in Seniors
🤔This study followed older adults for 9 years and found that those assigned to long-term high‑intensity interval training (HIIT) actually had slightly more hippocampal and thalamic atrophy than controls who just followed national physical activity guidelines, while higher baseline fitness...
APOE Ε4 Predicts Early Cognitive Decline in Midlife Adults
APOE ε4 and Accelerated Cognitive Decline Among Cognitively Healthy Middle-Aged and Older Adults 🗣️” In this study, APOE ε4 carrier status was associated with early cognitive decline, highlighting midlife risk awareness and lifestyle interventions, while non-APOE polygenic risk may require longer...
Celastrol Disrupts Hsc70‑Bim to Boost Longevity, Reduce Fibrosis
Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis https://t.co/Iv51QlhH5l
Centenarians Defy Immunosenescence, Boost Geroscience Insight
Biological age and immunosenescence in Colombian centenarians “These findings challenge the notion of immunosenescence in centenarians and highlight the value of translational research in geroscience.” https://t.co/e63NgGmmzL
Resistance Training Cuts Fat and Boosts Grip Strength
Exercise, nutrition, physical agent therapy in older adults with sarcopenic obesity: a systematic review and network meta-analysis RT can reduce BF% while simultaneously improving grip strength, representing an effective management strategy for sarcopenic obesity. https://t.co/p0wR2R5M1E
Irregular Bedtimes Double Risk of Major Cardiac Events
Sleep timing irregularity in midlife: association with incident major adverse cardiac events and cardiovascular disease mortality over a 10-year follow-up 🫀Individuals with irregular bedtimes had a 2-fold higher risk of MACEs compared to those with regular bedtimes Irregular sleep midpoints? Also a...
Tenofovir Alafenamide Cuts Biological Age in Adults
An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics 💫 https://t.co/FFvTmJv2zv https://t.co/DHHQ18nAmy
Century of Gains Slows; Future Life Expectancy Uncertain
Life expectancy in high-income countries increased ~50% over the past century, but gains have slowed in recent decades (≈70 in 1975 to ≈80 today in US). What will be the life expectancy in 100 years?
Choose Triglyceride Omega‑3s for Superior Absorption
Not all omega-3 supplements are created equal. Most fish oil on the market is in ethyl ester form, which is cheaper to produce after purification. But it's not found in nature and is less bioavailable. What you want is triglyceride form omega-3s....
Promising Longevity Molecule Stalled by Misaligned Incentives
The Longevity Drug You’ve Never Heard Of This is one of those stories that captures both the promise—and the frustration—of longevity science. In this preview episode, Dr. George Sutphin (@senmorteco ), Associate Professor of Molecular and Cellular Biology at the @uarizona @UAZCancer , walks...
Excess Energy Resistance Drives Aging; Lifestyle Lowers It
The energy resistance principle 💡Hypothesis and framework by @MitoPsychoBio & colleagues ⚡️ 👉 “Energy resistance (éR) is the fundamental property that enables transformation, converting into useful work the unformed energy potential of food-derived electrons fluxing toward oxygen. 👉 Although éR is required to...
Vaccinated Donor Plasma Contains No Spike Proteins or mRNA
One of the top questions I get about young plasma exchange (YPE): “What if the donor was vaccinated? Does that mean I’m getting spike proteins or mRNA injected into me?” Short answer: No. Here’s the breakdown... https://t.co/JDoAi2yPmR
GLP‑1 Drugs Aren’t a One‑size‑fit Solution
Should everyone be taking a GLP-1 medication? From my discussion with @RealDoctorMike on his podcast https://t.co/d3M8cFHggz
Higher Muscle Strength Cuts Mortality Risk in Elderly Women
Muscular Strength and Mortality in Women Aged 63 to 99 Years 👉 “this study of ambulatory older women, greater muscular strength was associated with lower mortality even when controlling for accelerometer-measured PA and sedentary time, walking speed, and systemic inflammation.” https://t.co/xi913FibKy
Garlic-Derived DAS Outperforms Metformin, Extending Mouse Lifespan
👉 “Chronic treatment with DAS (found in garlic 🧄) freshly added to the diet weekly revealed geroprotective effects, since it extended lifespan and improved metabolic homeostasis, locomotor function, and relevant cognitive parameters in wild-type male mice fed with an STD....
Eat 30 Plant Varieties Weekly for Microbiome Health
As a scientist studying aging, I’m fully behind the “eat 30 different plant foods per week” advice. The research linking microbiome diversity to long-term health is compelling. Fruit, veg, legumes, herbs, nuts, and seeds all count — it’s more achievable than...
Blood and Fat Markers Forecast Heart Disease Risk
Neutrophil-to-Lymphocyte Ratio, Bone Marrow, and Visceral Fat Metabolism as Predictors of Future Cardiovascular Disease in an Asymptomatic Healthy Population https://t.co/Oq1a3fH5qa
Immune‑Inflammatory Balance Linked to Extreme Longevity
Immune-Inflammatory Response in Lifespan—What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study https://t.co/UPfK7vrIUT #mdpibiology
Rejuvenated CD4 T Cells Promote Longevity, Infections Accelerate Senescence
Rejuvenated CD4 T cells--> longevity https://t.co/FH5XTQc3zl On the other hand, infection-->increased senescent T cells, shorter lifespan? https://t.co/wtsDnmIdnh
Prioritize Performance; Longevity Follows as a Bonus
The goal isn’t longer life.�It’s longer function and performance. Longer life is the side effect
Modern Bodies Face a Silent Energy Crisis
Fuel for thought 👉 ”A quiet energy crisis may be unfolding within modern bodies…” and brain 👨🏻⚕️🧠 🔗 https://t.co/19h7kfdhNK 🗣️@HanCritchlow
Key Nutrients: Vitamin D, B‑vitamins, Magnesium, Melatonin, NAD
Vitamin D is the master hormone. B vitamins are the master vitamins. Magnesium is the master mineral. Melatonin is the master antioxidant. NAD is the master coenzyme.
High-Dose Vitamin C May Slow Aging, Study Finds
New research in Cell Metabolism suggest high-dose vitamin C might slow aging👇 (details in comments)
Scientists Reverse Mouse Aging by 75%, Promising Human Breakthroughs
Dr. David Sinclair just dropped a two-hour masterclass on Tom Bilyeu's podcast. He shared 10 mind-blowing insights on how to reverse biological age in animals (and why it should work in humans too). 1) They already reversed a mice's age by 75%...
Certain Drugs Like SGLT2 Inhibitors Cut Mortality Risk
A 2024 study on half a million UK individuals analyzed the mortality effects of 406 medications 92% were seen to be associated with increased mortality risk because of the underlying diseases. However, 14 were surprisingly associated with reduced mortality. An overview by...
Ageing Biomarkers Compared Across Humans and Primates
Biomarkers of ageing of humans and non-human primates https://t.co/Cav2bIwrLX "A comprehensive overview of ageing biomarkers in humans and non-human primates, divided into three hierarchical levels: cellular, tissue and organism..." https://t.co/tT3JXBnj0S