Battery‑free Textile Powers Real‑time Blood Pressure Monitoring
A new battery-free textile enables continuous, real-time monitoring of systolic blood pressure by wirelessly connecting ultra-thin epidermal sensors to a smartphone, eliminating the need for bulky batteries in wearable health technology. wearabletech
GLP‑1 Weight Loss Drugs Lower HRV, Raise Heart Rate
Reducing body weight with GLP-1 agonists isn't a free lunch: negative impacts on HRV, RHR GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons https://t.co/4QNy141TtK
Simple 10-Step Routine for Health and Longevity Under 40
Health and longevity routine for people under 40: 1. Lift weights 2-3x a week, focusing on strength 2. Cardio 2x a week, mix of HIIT and zone 2 3. Sleep 7-8 hours 4. Eat a predominantly whole foods diet, no need for restrictive diets 5....
APOE4 Raises Alzheimer Risk, but Lifestyle Can Shift Outcomes
APOE Status and Dementia Risk... APOE4 is the strongest common genetic risk factor for late-onset Alzheimer's. About 25% of the population carries at least one copy. It's a risk modifier... not a guarantee. And the levers that change the trajectory are...
Epigenetic Plasticity Enables Precision Targeting of Senescent Cells
Epigenetic regulation of cellular senescence "This review proposes a roadmap for leveraging epigenetic plasticity, offering a precision medicine approach to target specific senescent cell populations and extend health span." https://t.co/UAuBP8WEeR https://t.co/i0XzhPM0NB
Wearables Create Lifelong Health Baselines for Future Goals
Wearables aren’t just for tracking you in real time They’re building your personal baseline The numbers you see today become the targets you’ll aim to return to decades from now https://t.co/S44Yk812Gp
Even at 82, Speed Training Pays Off
82-year-old Domenic Stallato runs 100 meters in 16.02 sec A physically active 30-year-old would run it in about 12-14 seconds Importance of training speed and power with age: https://t.co/HSHGgsTIYU https://t.co/gZppsjkstC
Anti‑inflammatory Diets Curb Neuroinflammation via Gut‑brain Axis
The relationship between dietary patterns and neuroinflammation "These nutritional changes contribute to a pro-inflammatory brain environment both directly, through the immunomodulatory effects of dietary components and metabolites, and indirectly, through increased intestinal permeability, dysbiosis, and activation of peripheral inflammatory cascades. Conversely, nutritional...
Longevity Market Set to Outpace AI at $8 Trillion
The rise of the longevity family office UBS projects an 8T global longevity market (surpassing AI as the largest category) 🔗https://t.co/Tp7fKl68VS Echoes what I'm seeing through longevity consulting and speaking at family office summits👨⚕️ 🔗https://t.co/TxbwLaEbmk | @Longevity_Inv
Choose Biolongevity Labs for 99% Pure Peptides
There's a lot of discourse online about peptides right now, but many people aren't telling you the truth. If you are looking for peptides that meet strict safety standards, I recommend Biolongevity Labs. USA-manufactured, third-party tested, with guaranteed 99% purity,...
Invest in Proven Canine Cardiac Reversal Biotech
I co-founded @RejuvenateBio & have enjoyed the science from day one. Cardiac disease reversal in dogs. 3 years of safety data. Zero safety signals. They’ve opened a unique opportunity for the biotech community to invest & secure equity at this early...
Vaccines May Modulate Dementia Risk via Trained Immunity
Infection, vaccination and risk of dementia: a proposed immunological model "Integrating data on BCG and mechanistic hypotheses, recent findings on the AS01 adjuvant, and the role of trained innate immunity, we describe here an immunological model that connects vaccine and adjuvant...
Scaling Cheap In‑Vivo Causal Testing for Age‑Related Diseases
AI has made hypothesis generation in bio cheap. Anyone can get an answer to ‘could this play a role in my disease’, but how do we go from ‘could’ to ‘does’? The scarce resource now is causal evidence to test hypotheses...
ER-100 Cleared for Trials; Safety Promising, Translation Uncertain
So far, the data suggest ER-100 should be safe in humans, and the FDA has cleared us to move into clinical trials. Translation from primates to humans is never guaranteed If it doesn’t work as hoped, we’ll learn & improve, just...
Longevity Needs Purpose, Not Just Optimization
Longevity without purpose is just survival. 1/ We're optimizing everything: sleep, nutrition, biomarkers, training zones. But have we forgotten to optimize meaning?
Midlife Vitamin D Deficiency Forecasts Tau Build‑Up 16 Years Later
Many papers associate low vitamin D levels w/ worse health outcomes. What's notable about this new study is how long subjects were followed: Low vitamin D in midlife predicted tau burden on PET 16 years later. https://t.co/rUWJGbZBgl https://t.co/Qf5z8ueKyp
Flavonoids Emerging as Powerful Tools Against Chronic Disease
Recent Advances in Flavonoids and Chronic Disease: Mechanisms, Therapeutic Applications, and Future Directions https://t.co/nh4sVRvjZo https://t.co/3nIIZm37Jl
Lifelong Cognitive Enrichment Slows Brain Aging
A new Neurology study just gave us one of the cleanest lifestyle signals for brain aging we have ever seen. As a medical school professor, I teach that the brain follows the same rule as every other organ: use it or...
Epigenetic Reset: Once Mocked,
From 2008-2024 I was accused of hyping (a common slur) for suggesting that changes to the epigenome might cause aging and that therapeutics could "allow us to reset the epigenome to a more youthful state." - Oberdoerffer & Sinclair...
Scalable Hypothesis‑testing Datasets Will Drive Biology’s AI ROI
Which AI-enabling datasets will bring the biggest ROI in biology? One type will be "ways to confirm hypotheses at scale". @GordianBio is building atlases of how every expressed gene target affects organs suffering diseases of aging.
Simple Habit May Prevent Alzheimer’s, 16‑year Study Finds
Want to Protect Your Brain From Alzheimer’s? A 16-Year Study Suggests a Simple Thing to Do Right Now https://t.co/JuRJJ4hRjE https://t.co/OeivZIC7Ln
Resistance Training Counters Age‑related Muscle Loss and Restores Protein Sensitivity
Muscle loss with age is common, but much of that decline is driven by inactivity, not aging alone. On average, we reach peak muscle mass somewhere between 20 and 30, then lose about 8% per decade after that. By the time...
Regulators Greenlight Wearables, Boosting Data, Speed, Tools
Apple, Oura, Whoop, Fitbit just got the regulatory green light to move faster. Good. More data + More speed + More tools in more hands = Every one of those is a win. https://t.co/CVva0zjYvz
Longevity Medicine Nears Science Cover as Field Accelerates
Longevity medicine may be closer to the cover of Science than most people realize.🩺 The science is accelerating across prevention, diagnostics, therapeutics, and healthspan. A creative concept, not an actual Science cover.👨⚕️ Created with ImageGen2 and curated by @agingdoc1. https://t.co/H36sbrc7NN
Aging Accelerates Damage Accumulation, Driving Senescence
Evolution of Senescence by Damage Accumulation That Accelerates With Age Throughout an Organism's Lifespan https://t.co/FAjw5M2mge https://t.co/pc3XZn5s1t
Longevity Escape Velocity Near; Avoid Stupid Deaths
We're so close to longevity escape velocity (LEV by 2033) that your sole responsibility right now is to avoid dying from something stupid. The next 5 years will deliver more medical breakthroughs than the previous 50.
Systems Thinking Unlocks Leverage to Slow Aging
The breakthrough in longevity science is systems thinking. When we map how aging actually works, we gain leverage to slow it down. https://t.co/sp3UfpvsTu
20‑Minute Neighborhoods Boost Brain Health in Seniors
Older adults living in 20-minute neighbourhoods showed brain structural patterns linked to healthier ageing, as well as greater resilience to cognitive impairment. This study from the University of Miami highlights how neighbourhood design may influence brain health as we age: https://t.co/rHipSOKA7k #research...
New AHA/ACC Guidelines Redefine Heart Disease Prevention
The biggest shift in cardiovascular prevention in years just dropped — and almost no one is talking about it. As a medical school professor, I've watched heart disease stay America's #1 killer for decades. New AHA/ACC guidelines finally move the line. What...
Half of NMN Supplements Mislabelled, May Harm Users
David Sinclair's research helped turn NMN into a billion-dollar industry. Now he says roughly half the products don't contain what's on the label - and some contain ingredients that could harm you Firstly, NMN (nicotinamide mononucleotide) is a molecule that converts to...
Memory Loss Can Spread via Gut Microbiome
Comment “curious” for the deep dive Memory loss might be… infectious. A new Nature study found that when young mice live with older mice that have poor memory, the young mice begin to lose memory too. The natural question is: why? The answer lies...
Fitness Drives Immune Resilience in Healthy Aging
Physical Fitness Dynamics Shape Immune Remodeling in Healthy Aging: A 3-Year Longitudinal Study 👉 “These results highlight physical fitness as a potentially modifiable determinant of immune trajectories and immune resilience in healthy aging.” https://t.co/NsgzpoH5Tb
OSK Reprogramming Restores Adult Heart Regeneration
NEW STUDY: OSK rewinds the clock and pushes adult heart cells into a regenerative state that improves heart repair Why is this such a big deal? Because adult heart cells do not meaningfully divide, which is why the heart heals with scar...
Insilico Launches First Longevity Board to Accelerate AI Aging Research
Insilico Medicine Announces Industry's First Longevity Board to Accelerate AI-Driven Aging Research for Drug Discovery https://t.co/Xd8GpDTVjW
Circadian Discipline: The Longevity Hack Behind a 100‑Year‑Old Scientist
Dr. G.P. Talwar turns 🎂100🎂 this year — founder of the National Institute of Immunology, India. Still shows up to work daily at the Talwar Foundation. Sharp mind, strong memory, fully independent. His secret? Circadian Discipline. A lifelong commitment to circadian rhythm—fixed sleep,...
Stay Alive Until the Decade’s Immortality Bridge Opens
You don’t need to live 100 years. You need to live long enough to live forever. The bridge is being built THIS decade. Your only job is to still be here when it opens. LEV-2033.
Genetic Bridge Links Ageing Theory to Lifespan Interventions
Dynamics of genetic and somatic trade-offs in ageing and mortality “These findings provide a genetic bridge between evolutionary theories of ageing and molecular mechanisms that can guide interventions to extend healthy lifespan.” https://t.co/HFGnELAIqH https://t.co/gAlE7D4OCh
Crowdfunded Rapamycin‑Exercise Trial Shows Promising Aging Data
Five years ago, @BradStanfieldMD reached out with an idea: a crowdfunded clinical trial testing rapamycin combined with exercise in older adults. The results are now published — and Brad and I just sat down for a full 42-minute breakdown...
Shingles Vaccine Cuts Dementia Risk by Half.
Have you had your shingles shot? A major 2026 study of over 300,000 people age 65 and older found that the shingles vaccine reduces the risk of dementia by up to 50%. Remarkably, men, women, and folks across age and ethnic...
Age‑and Sex‑Specific Genes Shape Lifespan Trade‑offs
Delighted to have contributed to this new study @Nature on the genetics of ageing and mortality 🧬 Using a large mouse cohort, we uncover age- and sex-specific genetic effects, including trade-offs where variants are beneficial early in life but detrimental later.
AI Discovers Chromogranin A Shields Brains From Alzheimer’s
20 to 30% of older adults have full blown Alzheimer's pathology in their brains (plaques, tangles etc.). But they never develop symptoms and nobody knew why. An AI just read thousands of human brains and named the reason: a protein...
Life Extension Moves From Radical Idea to Mainstream
Radical No More: Societal Perceptions of Life Extension – Past, Present, and Future Directions https://t.co/BQnufr6ofI | @KeithComito https://t.co/wpJnExMevT
Zepbound Sparks Diet Shift, Slashes LDL by One‑third
Patient started Zepbound and cut their LDL cholesterol essentially by a third and no longer in the range to start a cholesterol medicine. The medicine doesn't lower LDL cholesterol that much, but it did allow her to eat a more plant-forward...
Six Key Habits to Safeguard Your Brain After 40
I’m a bioscientist studying aging & dementia prevention 🧬 If you’re 40+, these 6 habits matter most for protecting your brain 🧠↓
Bitter Foods Linked to Better Blood Sugar Control
Eating more bitter foods (including dark chocolate and broccoli, which I never thought bitter but…whatever…) might be associated with better blood sugar outcomes: https://t.co/fKgAK7GsLw. Here’s my go-to bitters capsule “pre-carb”: @GetKion https://t.co/5qCmeOjebh https://t.co/pCTeB5YT1W
Healthy Fats Boost Mind, Body, and Longevity
Anyone telling you to cut out all of the fat in your diet has no idea what they are talking about. Want more options on foods that will benefit your mind, body, and longevity? My Bulletproof Cookbook is full of...
Longevity Linked to Ion Transport, Not Cell Division Genes
Why some species age slower than others remains a mystery. This is an impressive analysis of genes linked to longevity evolution in mammals. Genes associated with cell division & DNA repair show negative correlations with lifespan evolution, while positively correlated genes are...
Understanding Broad Aging Slowdown vs Targeted Rejuvenation
The 2 Longevity Fields... New post on a topic of great importance. Long, but something I feel strongly about. Broadly Slowing Aging vs. Divide-and-Conquer Rejuvenation: How to tell the difference and why acknowledging both matters (link in next post) https://t.co/khHlClSAWo
Sleep: A Modifiable Key to Aging and Alzheimer’s
“If sleep is a missing piece in the explanatory puzzle of aging and Alzheimer’s disease, then maybe we can do something about it. Sleep is a modifiable factor.” — Dr. Matthew Walker Listen to my interview with sleep expert Dr. Matthew Walker:...
Health Crises Reveal CEOs Neglect Lifestyle Management
I thought I was having a heart attack. Hospital three times in two years. Every time the verdict: nothing wrong. The fix wasn't medical. It was how I ran my health. Most CEOs get this backwards. https://t.co/V6hjnDkJRX